Relationships between serum leptin level and severity of positive symptoms in schizophrenia

Yoichiro Takayanagi; Nicola G. Cascella; Debby Santora; Patricia E. Gregory; Akira Sawa; William W Eaton

doi:10.1016/j.neures.2013.07.003

Relationships between serum leptin level and severity of positive symptoms in schizophrenia

Yoichiro Takayanagi, Nicola G. Cascella, Debby Santora, Patricia E. Gregory, Akira Sawa, William W Eaton

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The adipocytokine leptin is a key mediator of energy homeostasis. Recent papers have suggested that leptin may also have roles in the brain however it is unclear whether leptin is connected to symptoms of mental disorders. In this study, we sought to clarify the relationships between serum leptin level and psychopathology in schizophrenia (SZ) patients. The severity of positive symptoms inversely correlated with the serum leptin levels among SZ patients. There was no correlation between leptin levels and negative symptoms or neurocognition. Our data suggest a role of leptin in SZ positive symptoms.

Original language	English (US)
Pages (from-to)	97-101
Number of pages	5
Journal	Neuroscience Research
Volume	77
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neures.2013.07.003
State	Published - Sep 2013

Keywords

Cognitive function
Leptin
Metabolic syndrome
Negative symptom
Positive symptoms
Schizophrenia

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neures.2013.07.003

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title = "Relationships between serum leptin level and severity of positive symptoms in schizophrenia",

abstract = "The adipocytokine leptin is a key mediator of energy homeostasis. Recent papers have suggested that leptin may also have roles in the brain however it is unclear whether leptin is connected to symptoms of mental disorders. In this study, we sought to clarify the relationships between serum leptin level and psychopathology in schizophrenia (SZ) patients. The severity of positive symptoms inversely correlated with the serum leptin levels among SZ patients. There was no correlation between leptin levels and negative symptoms or neurocognition. Our data suggest a role of leptin in SZ positive symptoms.",

keywords = "Cognitive function, Leptin, Metabolic syndrome, Negative symptom, Positive symptoms, Schizophrenia",

author = "Yoichiro Takayanagi and Cascella, {Nicola G.} and Debby Santora and Gregory, {Patricia E.} and Akira Sawa and Eaton, {William W}",

note = "Funding Information: This study is supported by NIH grants ( MH-53188 to WWE). AS is supported by NIH grants ( MH-084018 , MH-094268 Silvio O. Conte center , MH-069853 , MH-085226 , MH-088753 , and MH-092443 ) and grants from Stanley, RUSK , S-R foundations , NARSAD , and MSCRF . This study was based on results from the Clinical Antipsychotic Trials of Intervention Effectiveness study, supported with Federal funds from the NIMH .",

year = "2013",

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doi = "10.1016/j.neures.2013.07.003",

language = "English (US)",

volume = "77",

pages = "97--101",

journal = "Neuroscience Research",

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AU - Takayanagi, Yoichiro

AU - Cascella, Nicola G.

AU - Santora, Debby

AU - Gregory, Patricia E.

AU - Sawa, Akira

AU - Eaton, William W

N1 - Funding Information: This study is supported by NIH grants ( MH-53188 to WWE). AS is supported by NIH grants ( MH-084018 , MH-094268 Silvio O. Conte center , MH-069853 , MH-085226 , MH-088753 , and MH-092443 ) and grants from Stanley, RUSK , S-R foundations , NARSAD , and MSCRF . This study was based on results from the Clinical Antipsychotic Trials of Intervention Effectiveness study, supported with Federal funds from the NIMH .

PY - 2013/9

Y1 - 2013/9

N2 - The adipocytokine leptin is a key mediator of energy homeostasis. Recent papers have suggested that leptin may also have roles in the brain however it is unclear whether leptin is connected to symptoms of mental disorders. In this study, we sought to clarify the relationships between serum leptin level and psychopathology in schizophrenia (SZ) patients. The severity of positive symptoms inversely correlated with the serum leptin levels among SZ patients. There was no correlation between leptin levels and negative symptoms or neurocognition. Our data suggest a role of leptin in SZ positive symptoms.

AB - The adipocytokine leptin is a key mediator of energy homeostasis. Recent papers have suggested that leptin may also have roles in the brain however it is unclear whether leptin is connected to symptoms of mental disorders. In this study, we sought to clarify the relationships between serum leptin level and psychopathology in schizophrenia (SZ) patients. The severity of positive symptoms inversely correlated with the serum leptin levels among SZ patients. There was no correlation between leptin levels and negative symptoms or neurocognition. Our data suggest a role of leptin in SZ positive symptoms.

KW - Cognitive function

KW - Leptin

KW - Metabolic syndrome

KW - Negative symptom

KW - Positive symptoms

KW - Schizophrenia

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JO - Neuroscience Research

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Relationships between serum leptin level and severity of positive symptoms in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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