Relationships between serum leptin level and severity of positive symptoms in schizophrenia

Yoichiro Takayanagi, Nicola G. Cascella, Debby Santora, Patricia E. Gregory, Akira Sawa, William W. Eaton

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The adipocytokine leptin is a key mediator of energy homeostasis. Recent papers have suggested that leptin may also have roles in the brain however it is unclear whether leptin is connected to symptoms of mental disorders. In this study, we sought to clarify the relationships between serum leptin level and psychopathology in schizophrenia (SZ) patients. The severity of positive symptoms inversely correlated with the serum leptin levels among SZ patients. There was no correlation between leptin levels and negative symptoms or neurocognition. Our data suggest a role of leptin in SZ positive symptoms.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalNeuroscience Research
Issue number1-2
StatePublished - Sep 2013


  • Cognitive function
  • Leptin
  • Metabolic syndrome
  • Negative symptom
  • Positive symptoms
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)


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