TY - JOUR
T1 - Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension
AU - Kostis, William J.
AU - Cabrera, Javier
AU - Hooper, W. Craig
AU - Whelton, Paul K.
AU - Espeland, Mark A.
AU - Cosgrove, Nora M.
AU - Cheng, Jerry
AU - Deng, Yingzi
AU - De Staerck, Christine
AU - Pyle, Meredith
AU - Maruthur, Nisa
AU - Reyes, Ingrid
AU - Anderson, Cheryl A.M.
AU - Liu, Jie
AU - Kostis, John B.
PY - 2013/4
Y1 - 2013/4
N2 - Salt sensitivity, the heterogeneity in the response of blood pressure (BP) to alterations in sodium intake, has been studied extensively, whereas weight sensitivity, the heterogeneity in BP response to weight change, has received scant attention. We examined the relationship of 21 gene polymorphisms previously found to be associated with hypertension, diabetes mellitus, or obesity, with weight sensitivity in the Trial of Nonpharmacologic Interventions in the Elderly, where participants with hypertension were randomized to receive intensive dietary intervention of sodium reduction, weight loss, both, or attention control, whereas pharmacological therapy was kept constant. After correcting for multiplicity, we identified significant associations of 3 polymorphisms with weight sensitivity of systolic BP (rs4646994, rs2820037, and rs1800629) and 3 polymorphisms for diastolic BP (rs4646994, rs2820037, and rs5744292). A recursive partitioning algorithm selected the combination of rs4646994, rs1800629, rs1982073, and rs1800896 as the set associated with the highest weight sensitivity. Polymorphisms related to hypertension, obesity, and diabetes mellitus are associated with weight sensitivity of BP.
AB - Salt sensitivity, the heterogeneity in the response of blood pressure (BP) to alterations in sodium intake, has been studied extensively, whereas weight sensitivity, the heterogeneity in BP response to weight change, has received scant attention. We examined the relationship of 21 gene polymorphisms previously found to be associated with hypertension, diabetes mellitus, or obesity, with weight sensitivity in the Trial of Nonpharmacologic Interventions in the Elderly, where participants with hypertension were randomized to receive intensive dietary intervention of sodium reduction, weight loss, both, or attention control, whereas pharmacological therapy was kept constant. After correcting for multiplicity, we identified significant associations of 3 polymorphisms with weight sensitivity of systolic BP (rs4646994, rs2820037, and rs1800629) and 3 polymorphisms for diastolic BP (rs4646994, rs2820037, and rs5744292). A recursive partitioning algorithm selected the combination of rs4646994, rs1800629, rs1982073, and rs1800896 as the set associated with the highest weight sensitivity. Polymorphisms related to hypertension, obesity, and diabetes mellitus are associated with weight sensitivity of BP.
KW - blood pressure
KW - genetics
KW - obesity
KW - sodium
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U2 - 10.1161/HYPERTENSIONAHA.111.00712
DO - 10.1161/HYPERTENSIONAHA.111.00712
M3 - Article
C2 - 23438931
AN - SCOPUS:84875225314
SN - 0194-911X
VL - 61
SP - 857
EP - 863
JO - Hypertension
JF - Hypertension
IS - 4
ER -