Relationships between reward sensitivity, risk-taking and family history of alcoholism during an interactive competitive fMRI task

Haley L. Yarosh, Christopher J. Hyatt, Shashwath A. Meda, Rachel Jiantonio-Kelly, Marc N. Potenza, Michal Assaf, Godfrey D. Pearlson

Research output: Contribution to journalArticle

Abstract

Background: Individuals with a positive family history for alcoholism (FHP) have shown differences from family-history-negative (FHN) individuals in the neural correlates of reward processing. FHP, compared to FHN individuals, demonstrate relatively diminished ventral striatal activation during anticipation of monetary rewards, and the degree of ventral striatal activation shows an inverse correlation with specific impulsivity measures in alcohol-dependent individuals. Rewards in socially interactive contexts relate importantly to addictive propensities, yet have not been examined with respect to how their neural underpinnings relate to impulsivity-related measures. Here we describe impulsivity measures in FHN and FHP individuals as they relate to a socially interactive functional magnetic resonance imaging (fMRI) task. Methods: Forty FHP and 29 FHN subjects without histories of Axis-I disorders completed a socially interactive Domino task during functional magnetic resonance imaging and completed self-report and behavioral impulsivity-related assessments. Results: FHP compared to FHN individuals showed higher scores (p = .004) on one impulsivity-related factor relating to both compulsivity (Padua Inventory) and reward/punishment sensitivity (Sensitivity to Punishment/Sensitivity to Reward Questionnaire). Multiple regression analysis within a reward-related network revealed a correlation between risk-taking (involving another impulsivity-related factor, the Balloon Analog Risk Task (BART)) and right ventral striatum activation under reward >punishment contrast (p

Original languageEnglish (US)
Article numbere88188
JournalPLoS One
Volume9
Issue number2
DOIs
StatePublished - Feb 4 2014
Externally publishedYes

Fingerprint

alcohol abuse
Risk-Taking
Impulsive Behavior
Reward
magnetic resonance imaging
Alcoholism
Chemical activation
Magnetic Resonance Imaging
History
Punishment
regression analysis
questionnaires
alcohols
Balloons
Corpus Striatum
Regression analysis
Alcohols
Processing
Self Report
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Yarosh, H. L., Hyatt, C. J., Meda, S. A., Jiantonio-Kelly, R., Potenza, M. N., Assaf, M., & Pearlson, G. D. (2014). Relationships between reward sensitivity, risk-taking and family history of alcoholism during an interactive competitive fMRI task. PLoS One, 9(2), [e88188]. https://doi.org/10.1371/journal.pone.0088188

Relationships between reward sensitivity, risk-taking and family history of alcoholism during an interactive competitive fMRI task. / Yarosh, Haley L.; Hyatt, Christopher J.; Meda, Shashwath A.; Jiantonio-Kelly, Rachel; Potenza, Marc N.; Assaf, Michal; Pearlson, Godfrey D.

In: PLoS One, Vol. 9, No. 2, e88188, 04.02.2014.

Research output: Contribution to journalArticle

Yarosh, HL, Hyatt, CJ, Meda, SA, Jiantonio-Kelly, R, Potenza, MN, Assaf, M & Pearlson, GD 2014, 'Relationships between reward sensitivity, risk-taking and family history of alcoholism during an interactive competitive fMRI task', PLoS One, vol. 9, no. 2, e88188. https://doi.org/10.1371/journal.pone.0088188
Yarosh, Haley L. ; Hyatt, Christopher J. ; Meda, Shashwath A. ; Jiantonio-Kelly, Rachel ; Potenza, Marc N. ; Assaf, Michal ; Pearlson, Godfrey D. / Relationships between reward sensitivity, risk-taking and family history of alcoholism during an interactive competitive fMRI task. In: PLoS One. 2014 ; Vol. 9, No. 2.
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