Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: A prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study

James H F Rudd, Kelly Myers, Sameer Bansilal, Josef Machac, Mark Woodward, Valentin Fuster, Michael E. Farkouh, Zahi A. Fayad

Research output: Contribution to journalArticle

Abstract

Background-Fluorodeoxyglucose positron-emission tomography (FDG PET) imaging of atherosclerosis has been used to quantify plaque inflammation and to measure the effect of plaque-stabilizing drugs. We explored how atherosclerotic plaque inflammation varies across arterial territories and how it relates to arterial calcification. We also tested the hypotheses that the degree of local arterial inflammation measured by PET is correlated with the extent of systemic inflammation and presence of risk factors for vascular disease. Methods and Results-Forty-one subjects underwent vascular PET/computed tomography imaging with FDG. All had either vascular disease or multiple risk factors. Forty subjects underwent carotid imaging, 27 subjects underwent aortic, 24 subjects iliac, and 13 subjects femoral imaging. Thirty-three subjects had a panel of biomarkers analyzed. We found strong associations between FDG uptake in neighboring arteries (left versus right carotid, r=0.91, P

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalCirculation: Cardiovascular Imaging
Volume2
Issue number2
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Arteritis
Biomarkers
Inflammation
Vascular Diseases
Atherosclerotic Plaques
Thigh
Positron-Emission Tomography
Blood Vessels
Atherosclerosis
Arteries
Tomography
Pharmaceutical Preparations
Positron Emission Tomography Computed Tomography

Keywords

  • Atherosclerosis
  • Calcification
  • Fluorodeoxyglucose
  • Imaging
  • Inflammation
  • Positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers : A prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study. / Rudd, James H F; Myers, Kelly; Bansilal, Sameer; Machac, Josef; Woodward, Mark; Fuster, Valentin; Farkouh, Michael E.; Fayad, Zahi A.

In: Circulation: Cardiovascular Imaging, Vol. 2, No. 2, 03.2009, p. 107-115.

Research output: Contribution to journalArticle

Rudd, James H F ; Myers, Kelly ; Bansilal, Sameer ; Machac, Josef ; Woodward, Mark ; Fuster, Valentin ; Farkouh, Michael E. ; Fayad, Zahi A. / Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers : A prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study. In: Circulation: Cardiovascular Imaging. 2009 ; Vol. 2, No. 2. pp. 107-115.
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