Relationships among maternal stress and depression, type 2 responses, and recurrent wheezing at age 3 years in low-income urban families

Sima K. Ramratnam, Cynthia M. Visness, Katy F. Jaffee, Gordon R. Bloomberg, Meyer Kattan, Megan T. Sandel, Robert A Wood, James E. Gern, Rosalind J. Wright

Research output: Contribution to journalArticle

Abstract

Rationale: Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development. Objectives: To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years. Methods: URECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years. Measurements and Main Results: Overall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P, 0.05). Maternal depression (any year) was significantly associated with recurrent wheezing (P <0.01). These associations were also significant when considered in a longitudinal analysis of cumulative stress and depression (P <0.02). Neither stress nor depression was significantly related to aeroallergen sensitization or antiviral responses. Contrary to our original hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with several type 2 cytokine responses. Conclusions: In urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.

Original languageEnglish (US)
Pages (from-to)674-681
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume195
Issue number5
DOIs
StatePublished - Mar 1 2017

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Respiratory Sounds
Mothers
Depression
Cytokines
Asthma
Antiviral Agents
Blood Cells
Parturition
Psychological Stress
Linear Models
Logistic Models
Viruses
Pregnancy

Keywords

  • Atopy
  • Depression
  • Inner city
  • Stress
  • Wheezing

ASJC Scopus subject areas

  • Medicine(all)
  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Relationships among maternal stress and depression, type 2 responses, and recurrent wheezing at age 3 years in low-income urban families. / Ramratnam, Sima K.; Visness, Cynthia M.; Jaffee, Katy F.; Bloomberg, Gordon R.; Kattan, Meyer; Sandel, Megan T.; Wood, Robert A; Gern, James E.; Wright, Rosalind J.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 195, No. 5, 01.03.2017, p. 674-681.

Research output: Contribution to journalArticle

Ramratnam, Sima K. ; Visness, Cynthia M. ; Jaffee, Katy F. ; Bloomberg, Gordon R. ; Kattan, Meyer ; Sandel, Megan T. ; Wood, Robert A ; Gern, James E. ; Wright, Rosalind J. / Relationships among maternal stress and depression, type 2 responses, and recurrent wheezing at age 3 years in low-income urban families. In: American Journal of Respiratory and Critical Care Medicine. 2017 ; Vol. 195, No. 5. pp. 674-681.
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T1 - Relationships among maternal stress and depression, type 2 responses, and recurrent wheezing at age 3 years in low-income urban families

AU - Ramratnam, Sima K.

AU - Visness, Cynthia M.

AU - Jaffee, Katy F.

AU - Bloomberg, Gordon R.

AU - Kattan, Meyer

AU - Sandel, Megan T.

AU - Wood, Robert A

AU - Gern, James E.

AU - Wright, Rosalind J.

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N2 - Rationale: Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development. Objectives: To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years. Methods: URECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years. Measurements and Main Results: Overall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P, 0.05). Maternal depression (any year) was significantly associated with recurrent wheezing (P <0.01). These associations were also significant when considered in a longitudinal analysis of cumulative stress and depression (P <0.02). Neither stress nor depression was significantly related to aeroallergen sensitization or antiviral responses. Contrary to our original hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with several type 2 cytokine responses. Conclusions: In urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.

AB - Rationale: Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development. Objectives: To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years. Methods: URECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years. Measurements and Main Results: Overall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P, 0.05). Maternal depression (any year) was significantly associated with recurrent wheezing (P <0.01). These associations were also significant when considered in a longitudinal analysis of cumulative stress and depression (P <0.02). Neither stress nor depression was significantly related to aeroallergen sensitization or antiviral responses. Contrary to our original hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with several type 2 cytokine responses. Conclusions: In urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.

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KW - Depression

KW - Inner city

KW - Stress

KW - Wheezing

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