Relationship of Weight Change Patterns from Young to Middle Adulthood with Incident Cardiovascular Diseases

Mengyi Liu, Zhuxian Zhang, Chun Zhou, Panpan He, Yuanyuan Zhang, Huan Li, Qinqin Li, Chengzhang Liu, Binyan Wang, Jianping Li, Yan Zhang, Xin Xu, Xiaobin Wang, Xiping Xu, Yong Huo, Fan Fan Hou, Xianhui Qin

Research output: Contribution to journalArticlepeer-review


Context: The effect of weight change patterns on cardiovascular diseases (CVD) remains uncertain. Objective: We aim to examine the relation of weight change patterns and absolute weight change from young adulthood to midlife with incident CVD. Design: Retrospective cohort study. Setting: National Health and Nutrition Examination Survey 1999-2016. Participants: A total of 20 715 US adults aged 40 through 79 with recalled weight at young adulthood (25 years) and midlife (10 years before baseline). Main Outcome Measure: CVD status was determined by self-report of a prior diagnosis, and age at diagnosis was used to establish time of CVD onset. CVD events was defined as the first occurrence of a congestive heart failure, coronary heart disease, angina pectoris, heart attack, or stroke. Results: After 9.76 years of follow-up, compared with participants who remained at normal weight, those in maximum overweight, changing from nonobese to obese, changing from obese to nonobese, maintaining obesity between young and middle adulthood had a 39% (hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.19-1.62), 93% (HR, 1.93; 95% CI, 1.64-2.28), 125% (HR, 2.25; 95% CI, 1.29-3.94), and 132% (HR, 2.32; 95% CI, 1.68-3.20) higher risk of CVD, respectively. In addition, compared with weight change within 2.5 kg, weight gain ≥ 10.0 kg was associated with higher risk of CVD. Conclusions: Both nonobese to obese, obese to nonobese, and stable obese from young to middle adulthood were associated with increased risks of CVD. The findings emphasize the importance of maintaining normal weight throughout the adulthood for preventing CVD in later life.

Original languageEnglish (US)
Pages (from-to)E812-E823
JournalJournal of Clinical Endocrinology and Metabolism
Issue number2
StatePublished - Feb 1 2021


  • Body weight change
  • cardiovascular diseases
  • midlife
  • obesity
  • young adulthood

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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