Relationship of vitamin D receptor gene polymorphisms with susceptibility, surgical outcome and prognosis of hallux valgus in a Chinese Han population

Tianqi Tao, Yiqiu Jiang, Wang Li, Yang Li, Jing Du, Jianchao Gui

Research output: Contribution to journalArticle

Abstract

Background: This study aimed to identify the relationship between the vitamin D receptor (VDR) BsmI gene polymorphism and risk factors, surgical outcome and prognosis of hallux valgus (HV). Methods: A case-control study was performed on a cohort of 236 HV patients and 236 controls in a Chinese Han population. Detection of the VDR BsmI/G2A polymorphism was performed using restriction fragment length polymorphism–polymerase chain reaction. Results: We detected a statistically significant difference in the allele distribution of the BsmI polymorphism between cases and controls (p < 0.01). Significant loss of hallux valgus angle (HVA) and intermetatarsal angle (IMA) correction was only noted in patients with the bb genotype during the 2-year follow-up period (p < 0.01). The average American Orthopaedic Foot and Ankle Society (AOFAS) scores at the 2-year follow-up were decreased in both groups when compared with those at the 6 month follow-up, and 1.45 points more decrease in patients with the bb genotype was observed as compared to those with the BB and Bb genotypes (p < 0.0001). The average visual analogue scales (VAS) also had the tendency with more pains in the bb genotype group (p < 0.0001). Furthermore, larger numbers of transfer metatarsalgia were found in patients with the bb genotype upon 2-year follow-up (p = 0.049). Conclusions: We report the first candidate gene polymorphism associated with susceptibility, surgical outcome and prognosis of HV in a Chinese Han population. Moreover, development of genetically-based method to predict the surgical outcome accurately and individualized therapy for HV are warranted.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalFoot and Ankle Surgery
Volume25
Issue number2
DOIs
StatePublished - Apr 1 2019
Externally publishedYes

Fingerprint

Hallux Valgus
Calcitriol Receptors
Genotype
Population
Genes
Metatarsalgia
Visual Analog Scale
Ankle
Orthopedics
Case-Control Studies
Foot
Alleles
Pain

Keywords

  • Hallux valgus
  • Polymorphism
  • Prognosis
  • rs1544410
  • Susceptibility

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Relationship of vitamin D receptor gene polymorphisms with susceptibility, surgical outcome and prognosis of hallux valgus in a Chinese Han population. / Tao, Tianqi; Jiang, Yiqiu; Li, Wang; Li, Yang; Du, Jing; Gui, Jianchao.

In: Foot and Ankle Surgery, Vol. 25, No. 2, 01.04.2019, p. 198-203.

Research output: Contribution to journalArticle

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AU - Jiang, Yiqiu

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AU - Du, Jing

AU - Gui, Jianchao

PY - 2019/4/1

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N2 - Background: This study aimed to identify the relationship between the vitamin D receptor (VDR) BsmI gene polymorphism and risk factors, surgical outcome and prognosis of hallux valgus (HV). Methods: A case-control study was performed on a cohort of 236 HV patients and 236 controls in a Chinese Han population. Detection of the VDR BsmI/G2A polymorphism was performed using restriction fragment length polymorphism–polymerase chain reaction. Results: We detected a statistically significant difference in the allele distribution of the BsmI polymorphism between cases and controls (p < 0.01). Significant loss of hallux valgus angle (HVA) and intermetatarsal angle (IMA) correction was only noted in patients with the bb genotype during the 2-year follow-up period (p < 0.01). The average American Orthopaedic Foot and Ankle Society (AOFAS) scores at the 2-year follow-up were decreased in both groups when compared with those at the 6 month follow-up, and 1.45 points more decrease in patients with the bb genotype was observed as compared to those with the BB and Bb genotypes (p < 0.0001). The average visual analogue scales (VAS) also had the tendency with more pains in the bb genotype group (p < 0.0001). Furthermore, larger numbers of transfer metatarsalgia were found in patients with the bb genotype upon 2-year follow-up (p = 0.049). Conclusions: We report the first candidate gene polymorphism associated with susceptibility, surgical outcome and prognosis of HV in a Chinese Han population. Moreover, development of genetically-based method to predict the surgical outcome accurately and individualized therapy for HV are warranted.

AB - Background: This study aimed to identify the relationship between the vitamin D receptor (VDR) BsmI gene polymorphism and risk factors, surgical outcome and prognosis of hallux valgus (HV). Methods: A case-control study was performed on a cohort of 236 HV patients and 236 controls in a Chinese Han population. Detection of the VDR BsmI/G2A polymorphism was performed using restriction fragment length polymorphism–polymerase chain reaction. Results: We detected a statistically significant difference in the allele distribution of the BsmI polymorphism between cases and controls (p < 0.01). Significant loss of hallux valgus angle (HVA) and intermetatarsal angle (IMA) correction was only noted in patients with the bb genotype during the 2-year follow-up period (p < 0.01). The average American Orthopaedic Foot and Ankle Society (AOFAS) scores at the 2-year follow-up were decreased in both groups when compared with those at the 6 month follow-up, and 1.45 points more decrease in patients with the bb genotype was observed as compared to those with the BB and Bb genotypes (p < 0.0001). The average visual analogue scales (VAS) also had the tendency with more pains in the bb genotype group (p < 0.0001). Furthermore, larger numbers of transfer metatarsalgia were found in patients with the bb genotype upon 2-year follow-up (p = 0.049). Conclusions: We report the first candidate gene polymorphism associated with susceptibility, surgical outcome and prognosis of HV in a Chinese Han population. Moreover, development of genetically-based method to predict the surgical outcome accurately and individualized therapy for HV are warranted.

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