Relationship of virulence factor expression to evolved virulence in mouse-passaged Cryptococcus neoformans lines

Erin E. McClelland, Wesley T. Perrine, Wayne K. Potts, Arturo Casadevall

Research output: Contribution to journalArticlepeer-review

Abstract

Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of virulence remain to be discovered.

Original languageEnglish (US)
Pages (from-to)7047-7050
Number of pages4
JournalInfection and immunity
Volume73
Issue number10
DOIs
StatePublished - Oct 2005
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Relationship of virulence factor expression to evolved virulence in mouse-passaged Cryptococcus neoformans lines'. Together they form a unique fingerprint.

Cite this