Relationship of the American heart association's impact goals (Life's Simple 7) with risk of chronic kidney disease: Results from the atherosclerosis risk in communities (ARIC) cohort study

Casey M. Rebholz, Cheryl A.M. Anderson, Morgan E. Grams, Lydia A. Bazzano, Deidra C. Crews, Alex R. Chang, Josef Coresh, Lawrence J. Appel

Research output: Contribution to journalArticlepeer-review

Abstract

Background-As part of its 2020 Impact Goals, the American Heart Association developed the Life's Simple 7 metric for cardiovascular health promotion. The relationship between the Life's Simple 7 metric and incident chronic kidney disease (CKD) is unknown. Methods and Results-We estimated the association between Life's Simple 7 and incident CKD in 14 832 Atherosclerosis Risk in Communities study participants. Ideal levels of Life's Simple 7 health factors were the following: nonsmoker or quit >1 year ago; body mass index <25 kg/m2; ≥150 minutes/week of physical activity; healthy dietary pattern (high in fruits and vegetables, fish, and fiber-rich whole grains; low in sodium and sugar-sweetened beverages); total cholesterol <200 mg/dL; blood pressure <120/ 80 mm Hg; and fasting blood glucose <100 mg/dL. At baseline, mean age was 54 years, 55% were women, and 26% were African American. There were 2743 incident CKD cases over a median follow-up of 22 years. Smoking, body mass index, physical activity, blood pressure, and blood glucose were associated with CKD risk (all P<0.01), but diet and blood cholesterol were not. CKD risk was inversely related to the number of ideal health factors (P-trend<0.001). A model containing the Life's Simple 7 health factors was more predictive of CKD risk than the base model including only age, sex, race, and estimated glomerular filtration rate (Life's Simple 7 health factors area under the ROC curve: 0.73, 95% CI: 0.72, 0.74 versus base model area under the ROC curve: 0.68, 95% CI: 0.67, 0.69; P<0.001). Conclusions-The AHA's Life's Simple 7 metric, developed to measure and promote cardiovascular health, predicts a lower risk of CKD.

Original languageEnglish (US)
Article numbere003192
JournalJournal of the American Heart Association
Volume5
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • Epidemiology
  • Kidney
  • Lifestyle
  • Prevention
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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