TY - JOUR
T1 - Relationship of sex steroid hormones with body size and with body composition measured by dual-energy X-ray absorptiometry in US men
AU - Trabert, Britton
AU - Graubard, Barry I.
AU - Nyante, Sarah J.
AU - Rifai, Nader
AU - Bradwin, Gary
AU - Platz, Elizabeth A.
AU - McQuillan, Geraldine M.
AU - McGlynn, Katherine A.
N1 - Funding Information:
Acknowledgments This work was supported by the Intramural Research Program of the National Institutes of Health, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services.
PY - 2012/12
Y1 - 2012/12
N2 - Purpose: To evaluate the association of body size - captured via whole-body dual-energy X-ray absorptiometry (DXA) and physical measurement - with serum sex steroid hormones and sex hormone binding globulin (SHBG), we utilized cross-sectional data and serum samples from the National Health and Nutrition Examination Survey (NHANES; 1999-2004). Methods: Testosterone, androstanediol glucuronide (3-alpha-diol-G), estradiol, and SHBG were measured via immunoassay in serum samples from a total of 898 adult men (ages 20-90) participating in the morning examination. As part of the NHANES data collection, DXA scans and measurements of weight, height, and waist circumference were performed by trained staff. Linear regression was used to estimate associations between body size and hormone levels adjusted for potential confounders and NHANES sampling procedures. Results: Total bone area (cm2) was inversely associated with total testosterone (ng/mL) [beta = -0.12; p value < 0.01], while bone mineral density (g/cm2) was inversely associated with SHBG (nmol/L) [beta = -17.16; p value = 0.01]. Increased percent body fat was associated with lower concentrations of total testosterone [beta = -0.16; p value < 0.01] and SHBG [beta = -1.11; p value < 0.01] and higher concentrations of free estradiol (fg/mL) [beta = 12.52; p value < 0.01]. Conclusions: Clinical measures of body fat (measured via DXA scan) and anthropometric measures of body fat (BMI and waist circumference) provided similar inferences regarding the association between increased body fat and hormone levels in men. Increased body fat was associated with lower circulating levels of testosterone (total and free) and SHBG and higher circulating levels of free estradiol in men, while decreased bone mineral density was associated with higher circulating levels of SHBG.
AB - Purpose: To evaluate the association of body size - captured via whole-body dual-energy X-ray absorptiometry (DXA) and physical measurement - with serum sex steroid hormones and sex hormone binding globulin (SHBG), we utilized cross-sectional data and serum samples from the National Health and Nutrition Examination Survey (NHANES; 1999-2004). Methods: Testosterone, androstanediol glucuronide (3-alpha-diol-G), estradiol, and SHBG were measured via immunoassay in serum samples from a total of 898 adult men (ages 20-90) participating in the morning examination. As part of the NHANES data collection, DXA scans and measurements of weight, height, and waist circumference were performed by trained staff. Linear regression was used to estimate associations between body size and hormone levels adjusted for potential confounders and NHANES sampling procedures. Results: Total bone area (cm2) was inversely associated with total testosterone (ng/mL) [beta = -0.12; p value < 0.01], while bone mineral density (g/cm2) was inversely associated with SHBG (nmol/L) [beta = -17.16; p value = 0.01]. Increased percent body fat was associated with lower concentrations of total testosterone [beta = -0.16; p value < 0.01] and SHBG [beta = -1.11; p value < 0.01] and higher concentrations of free estradiol (fg/mL) [beta = 12.52; p value < 0.01]. Conclusions: Clinical measures of body fat (measured via DXA scan) and anthropometric measures of body fat (BMI and waist circumference) provided similar inferences regarding the association between increased body fat and hormone levels in men. Increased body fat was associated with lower circulating levels of testosterone (total and free) and SHBG and higher circulating levels of free estradiol in men, while decreased bone mineral density was associated with higher circulating levels of SHBG.
KW - Androstanediol glucuronide
KW - DXA
KW - Dual-energy X-ray absorptiometry
KW - Estradiol
KW - Men
KW - NHANES
KW - National Health and Nutrition Examination Survey
KW - Sex hormone binding globulin
KW - Testosterone
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U2 - 10.1007/s10552-012-0024-9
DO - 10.1007/s10552-012-0024-9
M3 - Article
C2 - 23053790
AN - SCOPUS:84878819074
SN - 0957-5243
VL - 23
SP - 1881
EP - 1891
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 12
ER -