Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: The dal-PLAQUE study

Raphaël Duivenvoorden, Venkatesh Mani, Mark Woodward, David Kallend, Gabriela Suchankova, Valentin Fuster, James H.F. Rudd, Ahmed Tawakol, Michael E. Farkouh, Zahi A. Fayad

Research output: Contribution to journalArticle

Abstract

Objectives This study sought to longitudinally investigate the relationship between a broad spectrum of serum inflammatory biomarkers and plaque inflammation assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). Background Both plaque inflammation and serum biomarkers of inflammation are associated with atherothrombotic events; however, the relationship between them is unclear. Methods We conducted a post hoc analysis of the dal-PLAQUE (A Randomized Placebo-Controlled Study of the Effect of RO4607381 on Progression or Regression of Atherosclerotic Plaque in Patients With Coronary Heart Disease [CHD] Including Patients With Other CHD Risk Factors), a randomized, placebo-controlled study of dalcetrapib, a cholesteryl ester transfer protein inhibitor, in 130 patients with coronary heart disease, or coronary heart disease risk equivalents on stable lipid-lowering therapy. Baseline and change after 3-month follow-up in inflammatory biomarker levels and baseline and change after 3-month follow-up in aorta and carotid 18F-FDG PET/CT (mean maximum target-to-background ratio of the most diseased segment [TBRmds]) were analyzed. Results Baseline myeloperoxidase positively correlated with baseline carotid TBR mds (rho = 0.25, p = 0.02). This correlation remained at the 3-month follow-up and was independent of traditional cardiovascular disease risk factors. Baseline lipoprotein-associated phospholipase A2 mass correlated with aorta TBRmds (rho = 0.21, p = 0.03). However, this correlation disappeared at the 3-month follow-up and was not independent of cardiovascular disease risk factors. There was no association between change from baseline in myeloperoxidase or lipoprotein-associated phospholipase A 2 mass and change from baseline in aorta and carotid TBR mds. Baseline and change from baseline in high sensitivity C-reactive protein, interleukin 6, soluble P-selectin, soluble E-selectin, soluble intracellular adhesion molecule 1, soluble vascular cell adhesion molecule 1, and matrix-metalloproteinase 3 and 9 did not correlate with baseline or change from baseline in carotid or aorta TBRmds. Conclusions Our data show that, in patients with coronary heart disease or at high risk of coronary heart disease on stable lipid-lowering therapy, circulating myeloperoxidase levels are associated with carotid plaque inflammation. (A Randomized, Placebo-controlled Study of the Effect of RO4607381 on Progression or Regression of Atherosclerotic Plaque in Patients With Coronary Heart Disease [CHD] Including Patients With Other CHD Risk Factors [dal-PLAQUE]; NCT00655473)

Original languageEnglish (US)
Pages (from-to)1087-1094
Number of pages8
JournalJACC: Cardiovascular Imaging
Volume6
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • atherosclerosis
  • fluorodeoxyglucose F 18 positron emission tomography
  • inflammatory biomarkers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Duivenvoorden, R., Mani, V., Woodward, M., Kallend, D., Suchankova, G., Fuster, V., Rudd, J. H. F., Tawakol, A., Farkouh, M. E., & Fayad, Z. A. (2013). Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: The dal-PLAQUE study. JACC: Cardiovascular Imaging, 6(10), 1087-1094. https://doi.org/10.1016/j.jcmg.2013.03.009