Relationship of serum and cerebrospinal fluid biomarkers with intracranial hypertension and cerebral hypoperfusion after severe traumatic brain injury

Deborah M. Stein, Allison Lindell, Karen R. Murdock, Joseph A. Kufera, Jay Menaker, Kaspar Keledjian, Grant V. Bochicchio, Bizhan Aarabi, Thomas M. Scalea

Research output: Contribution to journalArticle

Abstract

Background: There is little that can be done to treat or reverse the primary injury that occurs at the time of a traumatic brain injury (TBI). Initial management of the patient with severe TBI focuses on prevention of subsequent secondary insults, namely, intracranial hypertension (ICH) and cerebral hypoperfusion (CH). Currently, there is no reliable way to predict which patients will develop ICH and CH other than clinical acumen; therefore, indicators of impending secondary intracranial insults may be useful in predicting these events and allowing for prevention and early intervention. This study was undertaken to investigate the relationship of cytokine levels with intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients with severe TBI. Methods: Patients at the R Adams Cowley Shock Trauma Center were prospectively enrolled for a 6-month period. Inclusion criteria were older than 17 years, admission within the first 6 hours after injury, Glasgow Coma Scale 20 mm Hg (% ICP20) and CPP 20 mm Hg (PTD ICP20) and CPP

Original languageEnglish (US)
Pages (from-to)1096-1103
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume70
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • Biomarkers
  • Cerebral hypoperfusion
  • Intracranial hypertension
  • Neuroinflammation
  • Traumatic brain injury

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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