TY - JOUR
T1 - Relationship of serum and cerebrospinal fluid biomarkers with intracranial hypertension and cerebral hypoperfusion after severe traumatic brain injury
AU - Stein, Deborah M.
AU - Lindell, Allison
AU - Murdock, Karen R.
AU - Kufera, Joseph A.
AU - Menaker, Jay
AU - Keledjian, Kaspar
AU - Bochicchio, Grant V.
AU - Aarabi, Bizhan
AU - Scalea, Thomas M.
PY - 2011/5
Y1 - 2011/5
N2 - Background: There is little that can be done to treat or reverse the primary injury that occurs at the time of a traumatic brain injury (TBI). Initial management of the patient with severe TBI focuses on prevention of subsequent secondary insults, namely, intracranial hypertension (ICH) and cerebral hypoperfusion (CH). Currently, there is no reliable way to predict which patients will develop ICH and CH other than clinical acumen; therefore, indicators of impending secondary intracranial insults may be useful in predicting these events and allowing for prevention and early intervention. This study was undertaken to investigate the relationship of cytokine levels with intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients with severe TBI. Methods: Patients at the R Adams Cowley Shock Trauma Center were prospectively enrolled for a 6-month period. Inclusion criteria were older than 17 years, admission within the first 6 hours after injury, Glasgow Coma Scale 20 mm Hg (% ICP20) and CPP 20 mm Hg (PTD ICP20) and CPP
AB - Background: There is little that can be done to treat or reverse the primary injury that occurs at the time of a traumatic brain injury (TBI). Initial management of the patient with severe TBI focuses on prevention of subsequent secondary insults, namely, intracranial hypertension (ICH) and cerebral hypoperfusion (CH). Currently, there is no reliable way to predict which patients will develop ICH and CH other than clinical acumen; therefore, indicators of impending secondary intracranial insults may be useful in predicting these events and allowing for prevention and early intervention. This study was undertaken to investigate the relationship of cytokine levels with intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients with severe TBI. Methods: Patients at the R Adams Cowley Shock Trauma Center were prospectively enrolled for a 6-month period. Inclusion criteria were older than 17 years, admission within the first 6 hours after injury, Glasgow Coma Scale 20 mm Hg (% ICP20) and CPP 20 mm Hg (PTD ICP20) and CPP
KW - Biomarkers
KW - Cerebral hypoperfusion
KW - Intracranial hypertension
KW - Neuroinflammation
KW - Traumatic brain injury
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U2 - 10.1097/TA.0b013e318216930d
DO - 10.1097/TA.0b013e318216930d
M3 - Article
C2 - 21610426
AN - SCOPUS:79955770615
SN - 0022-5282
VL - 70
SP - 1096
EP - 1103
JO - Journal of Trauma - Injury, Infection and Critical Care
JF - Journal of Trauma - Injury, Infection and Critical Care
IS - 5
ER -