Relationship of Physical Frailty to Phosphocreatine Recovery in Muscle after Mild Exercise Stress in the Oldest-Old Women

R. Varadhan, D. W. Russ, R. E. Gabr, J. Huang, R. R. Kalyani, Q. L. Xue, A. R. Cappola, K. Bandeen-Roche, L. P. Fried

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Physical frailty is a clinical syndrome associated with aging and manifesting as slowness, weakness, reduced physical activity, weight loss, and/or exhaustion. Frail older adults often report that their major problem is "low energy", and there is indirect evidence to support the hypothesis that frailty is a syndrome of dysregulated energetics. We hypothesized that altered cellular energy production underlies compromised response to stressors in the frail. METHODS: We conducted a pilot study to assess muscle energetics in response to a mild isometric exercise challenge in women (n=30) ages 84-93 years. The frailty status was assessed by a validated physical frailty instrument. Localized phosphorus (P31) magnetic resonance spectroscopy with a 1.5T magnet was used to assess the kinetics of Phosphocreatine recovery in the tibialis anterior muscle following maximal isometric contraction for 30 seconds. RESULTS: Phosphocreatine recovery following exertion, age-adjusted, was slowest in the frail group (mean=189 sec; 95%CI: 150,228) compared to pre-frail (mean=152 sec; 95%CI: 107,197) and nonfrail subjects (mean=132 sec; 95%CI: 40,224). The pre-frail and frail groups had 20 sec (95%CI: -49,89) and 57 sec (95%CI: -31,147) slower phosphocreatine recovery, respectively, than the non-frail. This response was paralleled by dysregulation in glucose recovery in response to oral glucose tolerance test in women from the same study population. CONCLUSIONS: Impaired muscle energetics and energy metabolism might be implicated in the physical frailty syndrome.

Original languageEnglish (US)
Pages (from-to)162-168
Number of pages7
JournalThe Journal of frailty & aging
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2019

Fingerprint

Phosphocreatine
Exercise
Muscles
Frail Elderly
Isometric Contraction
Magnets
Glucose Tolerance Test
Phosphorus
Energy Metabolism
Weight Loss
Magnetic Resonance Spectroscopy
Glucose
Population

Keywords

  • dynamical system
  • energy
  • Magnetic resonance spectroscopy
  • stimulus response

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Relationship of Physical Frailty to Phosphocreatine Recovery in Muscle after Mild Exercise Stress in the Oldest-Old Women. / Varadhan, R.; Russ, D. W.; Gabr, R. E.; Huang, J.; Kalyani, R. R.; Xue, Q. L.; Cappola, A. R.; Bandeen-Roche, K.; Fried, L. P.

In: The Journal of frailty & aging, Vol. 8, No. 4, 01.01.2019, p. 162-168.

Research output: Contribution to journalArticle

@article{e589baaabfcc4b97a0200810deef2022,
title = "Relationship of Physical Frailty to Phosphocreatine Recovery in Muscle after Mild Exercise Stress in the Oldest-Old Women",
abstract = "BACKGROUND: Physical frailty is a clinical syndrome associated with aging and manifesting as slowness, weakness, reduced physical activity, weight loss, and/or exhaustion. Frail older adults often report that their major problem is {"}low energy{"}, and there is indirect evidence to support the hypothesis that frailty is a syndrome of dysregulated energetics. We hypothesized that altered cellular energy production underlies compromised response to stressors in the frail. METHODS: We conducted a pilot study to assess muscle energetics in response to a mild isometric exercise challenge in women (n=30) ages 84-93 years. The frailty status was assessed by a validated physical frailty instrument. Localized phosphorus (P31) magnetic resonance spectroscopy with a 1.5T magnet was used to assess the kinetics of Phosphocreatine recovery in the tibialis anterior muscle following maximal isometric contraction for 30 seconds. RESULTS: Phosphocreatine recovery following exertion, age-adjusted, was slowest in the frail group (mean=189 sec; 95{\%}CI: 150,228) compared to pre-frail (mean=152 sec; 95{\%}CI: 107,197) and nonfrail subjects (mean=132 sec; 95{\%}CI: 40,224). The pre-frail and frail groups had 20 sec (95{\%}CI: -49,89) and 57 sec (95{\%}CI: -31,147) slower phosphocreatine recovery, respectively, than the non-frail. This response was paralleled by dysregulation in glucose recovery in response to oral glucose tolerance test in women from the same study population. CONCLUSIONS: Impaired muscle energetics and energy metabolism might be implicated in the physical frailty syndrome.",
keywords = "dynamical system, energy, Magnetic resonance spectroscopy, stimulus response",
author = "R. Varadhan and Russ, {D. W.} and Gabr, {R. E.} and J. Huang and Kalyani, {R. R.} and Xue, {Q. L.} and Cappola, {A. R.} and K. Bandeen-Roche and Fried, {L. P.}",
year = "2019",
month = "1",
day = "1",
doi = "10.14283/jfa.2019.21",
language = "English (US)",
volume = "8",
pages = "162--168",
journal = "The Journal of frailty & aging",
issn = "2260-1341",
publisher = "Serdi Publishing Company",
number = "4",

}

TY - JOUR

T1 - Relationship of Physical Frailty to Phosphocreatine Recovery in Muscle after Mild Exercise Stress in the Oldest-Old Women

AU - Varadhan, R.

AU - Russ, D. W.

AU - Gabr, R. E.

AU - Huang, J.

AU - Kalyani, R. R.

AU - Xue, Q. L.

AU - Cappola, A. R.

AU - Bandeen-Roche, K.

AU - Fried, L. P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUND: Physical frailty is a clinical syndrome associated with aging and manifesting as slowness, weakness, reduced physical activity, weight loss, and/or exhaustion. Frail older adults often report that their major problem is "low energy", and there is indirect evidence to support the hypothesis that frailty is a syndrome of dysregulated energetics. We hypothesized that altered cellular energy production underlies compromised response to stressors in the frail. METHODS: We conducted a pilot study to assess muscle energetics in response to a mild isometric exercise challenge in women (n=30) ages 84-93 years. The frailty status was assessed by a validated physical frailty instrument. Localized phosphorus (P31) magnetic resonance spectroscopy with a 1.5T magnet was used to assess the kinetics of Phosphocreatine recovery in the tibialis anterior muscle following maximal isometric contraction for 30 seconds. RESULTS: Phosphocreatine recovery following exertion, age-adjusted, was slowest in the frail group (mean=189 sec; 95%CI: 150,228) compared to pre-frail (mean=152 sec; 95%CI: 107,197) and nonfrail subjects (mean=132 sec; 95%CI: 40,224). The pre-frail and frail groups had 20 sec (95%CI: -49,89) and 57 sec (95%CI: -31,147) slower phosphocreatine recovery, respectively, than the non-frail. This response was paralleled by dysregulation in glucose recovery in response to oral glucose tolerance test in women from the same study population. CONCLUSIONS: Impaired muscle energetics and energy metabolism might be implicated in the physical frailty syndrome.

AB - BACKGROUND: Physical frailty is a clinical syndrome associated with aging and manifesting as slowness, weakness, reduced physical activity, weight loss, and/or exhaustion. Frail older adults often report that their major problem is "low energy", and there is indirect evidence to support the hypothesis that frailty is a syndrome of dysregulated energetics. We hypothesized that altered cellular energy production underlies compromised response to stressors in the frail. METHODS: We conducted a pilot study to assess muscle energetics in response to a mild isometric exercise challenge in women (n=30) ages 84-93 years. The frailty status was assessed by a validated physical frailty instrument. Localized phosphorus (P31) magnetic resonance spectroscopy with a 1.5T magnet was used to assess the kinetics of Phosphocreatine recovery in the tibialis anterior muscle following maximal isometric contraction for 30 seconds. RESULTS: Phosphocreatine recovery following exertion, age-adjusted, was slowest in the frail group (mean=189 sec; 95%CI: 150,228) compared to pre-frail (mean=152 sec; 95%CI: 107,197) and nonfrail subjects (mean=132 sec; 95%CI: 40,224). The pre-frail and frail groups had 20 sec (95%CI: -49,89) and 57 sec (95%CI: -31,147) slower phosphocreatine recovery, respectively, than the non-frail. This response was paralleled by dysregulation in glucose recovery in response to oral glucose tolerance test in women from the same study population. CONCLUSIONS: Impaired muscle energetics and energy metabolism might be implicated in the physical frailty syndrome.

KW - dynamical system

KW - energy

KW - Magnetic resonance spectroscopy

KW - stimulus response

UR - http://www.scopus.com/inward/record.url?scp=85073656547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073656547&partnerID=8YFLogxK

U2 - 10.14283/jfa.2019.21

DO - 10.14283/jfa.2019.21

M3 - Article

C2 - 31637400

AN - SCOPUS:85073656547

VL - 8

SP - 162

EP - 168

JO - The Journal of frailty & aging

JF - The Journal of frailty & aging

SN - 2260-1341

IS - 4

ER -