Relationship of neuroleptic drug effects at brain dopamine, serotonin, α-adrenergic, and histamine receptors to clinical potency

S. J. Peroutka, S. H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

The authors examined the potencies of 22 neuroleptic drugs competing for binding sites associated with dopamine, serotonin, α-adrenergic, and histamine receptors in brain membranes. They found that although many neuroleptics are quite potent in competing at several of these receptor sites, the average antipsychotic clinical potency correlates closely only with the drug affinity for dopamine receptors labeled by 3H-spiroperidol. At clinically effective doses, however, substantial occupancy of serotonin, α-adrenergic, and histamine receptors often occurs and may account for some of the auxiliary actions of neuroleptics.

Original languageEnglish (US)
Pages (from-to)1518-1522
Number of pages5
JournalAmerican Journal of Psychiatry
Volume137
Issue number12
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Psychiatry and Mental health

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