TY - JOUR
T1 - Relationship of neuroleptic drug effects at brain dopamine, serotonin, α-adrenergic, and histamine receptors to clinical potency
AU - Peroutka, S. J.
AU - Snyder, S. H.
PY - 1980
Y1 - 1980
N2 - The authors examined the potencies of 22 neuroleptic drugs competing for binding sites associated with dopamine, serotonin, α-adrenergic, and histamine receptors in brain membranes. They found that although many neuroleptics are quite potent in competing at several of these receptor sites, the average antipsychotic clinical potency correlates closely only with the drug affinity for dopamine receptors labeled by 3H-spiroperidol. At clinically effective doses, however, substantial occupancy of serotonin, α-adrenergic, and histamine receptors often occurs and may account for some of the auxiliary actions of neuroleptics.
AB - The authors examined the potencies of 22 neuroleptic drugs competing for binding sites associated with dopamine, serotonin, α-adrenergic, and histamine receptors in brain membranes. They found that although many neuroleptics are quite potent in competing at several of these receptor sites, the average antipsychotic clinical potency correlates closely only with the drug affinity for dopamine receptors labeled by 3H-spiroperidol. At clinically effective doses, however, substantial occupancy of serotonin, α-adrenergic, and histamine receptors often occurs and may account for some of the auxiliary actions of neuroleptics.
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U2 - 10.1176/ajp.137.12.1518
DO - 10.1176/ajp.137.12.1518
M3 - Article
C2 - 6108081
AN - SCOPUS:0019174607
VL - 137
SP - 1518
EP - 1522
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 12
ER -