TY - JOUR
T1 - Relationship of MTHFR gene 677C→T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes
AU - Qin, Xianhui
AU - Li, Youbao
AU - Yuan, Hui
AU - Xie, Di
AU - Tang, Genfu
AU - Wang, Binyan
AU - Wang, Xiaobin
AU - Xu, Xin
AU - Xu, Xiping
AU - Hou, Fanfan
N1 - Publisher Copyright:
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2015/2/7
Y1 - 2015/2/7
N2 - East Asian patients with diabetes have a higher risk for renal complications and strokes than Europeans. We aimed to evaluate the effect of methylenetetrahydrofolate reductase (MTHFR) gene 677C→T polymorphism, which was associated with a higher stroke risk and was common in the Chinese population, as well as homocysteine and estimated glomerular filtration rate (eGFR) levels on the risk of new-onset diabetes (NOD). A total of 2422 subjects without diabetes were followed-up for 7 years. NOD was defined as fasting plasma glucose ≥7.0mmol/L or self-reported physician diagnosis of diabetes. Compared with subjects with MTHFR 677CC genotype, those with TT genotype had a higher risk of NOD in females (odds ratio 2.78, 95% confidence interval 1.39-5.56) but not in males (0.80, 0.40-1.61, P for interaction=0.008). Furthermore, MTHFR 677C→T polymorphism was more strongly associated with the risk of NOD among females with higher body mass index (BMI, ≥23 vs <23kg/m 2, P for interaction=0.009) or lower high-density lipoprotein-cholesterol (HDL-C, <1.3 vs ≥1.3mmol/L, P for interaction=0.015) levels. Hyperhomocysteinemia (≥16 vs <10μmol/L) was not significantly associated with NOD in males (0.88, 0.42-1.85) or females (1.52, 0.65-3.57). However, mildly decreased eGFR (<90 vs 90-120mL/min/1.73m 2) was associated with NOD mainly in males (1.96, 1.01-3.78; females, 0.74, 0.32-1.72, P for interaction=0.134). Females with MTHFR 677TT genotype had a significantly higher risk of NOD, particularly those with higher BMI or low HDL-C levels. The higher risk of NOD associated with mildly decreased eGFR also warrants more investigation. Our results provide insights into the ethnic differences of diabetic complications between East Asian patients and Europeans.
AB - East Asian patients with diabetes have a higher risk for renal complications and strokes than Europeans. We aimed to evaluate the effect of methylenetetrahydrofolate reductase (MTHFR) gene 677C→T polymorphism, which was associated with a higher stroke risk and was common in the Chinese population, as well as homocysteine and estimated glomerular filtration rate (eGFR) levels on the risk of new-onset diabetes (NOD). A total of 2422 subjects without diabetes were followed-up for 7 years. NOD was defined as fasting plasma glucose ≥7.0mmol/L or self-reported physician diagnosis of diabetes. Compared with subjects with MTHFR 677CC genotype, those with TT genotype had a higher risk of NOD in females (odds ratio 2.78, 95% confidence interval 1.39-5.56) but not in males (0.80, 0.40-1.61, P for interaction=0.008). Furthermore, MTHFR 677C→T polymorphism was more strongly associated with the risk of NOD among females with higher body mass index (BMI, ≥23 vs <23kg/m 2, P for interaction=0.009) or lower high-density lipoprotein-cholesterol (HDL-C, <1.3 vs ≥1.3mmol/L, P for interaction=0.015) levels. Hyperhomocysteinemia (≥16 vs <10μmol/L) was not significantly associated with NOD in males (0.88, 0.42-1.85) or females (1.52, 0.65-3.57). However, mildly decreased eGFR (<90 vs 90-120mL/min/1.73m 2) was associated with NOD mainly in males (1.96, 1.01-3.78; females, 0.74, 0.32-1.72, P for interaction=0.134). Females with MTHFR 677TT genotype had a significantly higher risk of NOD, particularly those with higher BMI or low HDL-C levels. The higher risk of NOD associated with mildly decreased eGFR also warrants more investigation. Our results provide insights into the ethnic differences of diabetic complications between East Asian patients and Europeans.
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U2 - 10.1097/MD.0000000000000563
DO - 10.1097/MD.0000000000000563
M3 - Article
C2 - 25700330
AN - SCOPUS:84928431404
SN - 0025-7974
VL - 94
SP - e563
JO - Medicine (United States)
JF - Medicine (United States)
IS - 7
ER -