Relationship of MTHFR gene 677C→T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes

Xianhui Qin, Youbao Li, Hui Yuan, Di Xie, Genfu Tang, Binyan Wang, Xiaobin Wang, Xin Xu, Xiping Xu, Fanfan Hou

Research output: Contribution to journalArticle

Abstract

East Asian patients with diabetes have a higher risk for renal complications and strokes than Europeans. We aimed to evaluate the effect of methylenetetrahydrofolate reductase (MTHFR) gene 677C→T polymorphism, which was associated with a higher stroke risk and was common in the Chinese population, as well as homocysteine and estimated glomerular filtration rate (eGFR) levels on the risk of new-onset diabetes (NOD). A total of 2422 subjects without diabetes were followed-up for 7 years. NOD was defined as fasting plasma glucose ≥7.0mmol/L or self-reported physician diagnosis of diabetes. Compared with subjects with MTHFR 677CC genotype, those with TT genotype had a higher risk of NOD in females (odds ratio 2.78, 95% confidence interval 1.39-5.56) but not in males (0.80, 0.40-1.61, P for interaction=0.008). Furthermore, MTHFR 677C→T polymorphism was more strongly associated with the risk of NOD among females with higher body mass index (BMI, ≥23 vs

Original languageEnglish (US)
Pages (from-to)e563
JournalMedicine (United States)
Volume94
Issue number7
DOIs
StatePublished - Feb 7 2015

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Methylenetetrahydrofolate Reductase (NADPH2)
Homocysteine
Glomerular Filtration Rate
Genes
Stroke
Genotype
Fasting
Body Mass Index
Odds Ratio
Confidence Intervals
Physicians
Kidney
Glucose
Population

ASJC Scopus subject areas

  • Medicine(all)

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Relationship of MTHFR gene 677C→T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes. / Qin, Xianhui; Li, Youbao; Yuan, Hui; Xie, Di; Tang, Genfu; Wang, Binyan; Wang, Xiaobin; Xu, Xin; Xu, Xiping; Hou, Fanfan.

In: Medicine (United States), Vol. 94, No. 7, 07.02.2015, p. e563.

Research output: Contribution to journalArticle

Qin, Xianhui ; Li, Youbao ; Yuan, Hui ; Xie, Di ; Tang, Genfu ; Wang, Binyan ; Wang, Xiaobin ; Xu, Xin ; Xu, Xiping ; Hou, Fanfan. / Relationship of MTHFR gene 677C→T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes. In: Medicine (United States). 2015 ; Vol. 94, No. 7. pp. e563.
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AU - Xie, Di

AU - Tang, Genfu

AU - Wang, Binyan

AU - Wang, Xiaobin

AU - Xu, Xin

AU - Xu, Xiping

AU - Hou, Fanfan

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