TY - JOUR
T1 - Relationship of menopausal symptoms and ovarian reserve in reproductive-aged cancer survivors
AU - Chemerinski, Anat
AU - Cameron, Katherine
AU - Sammel, Mary
AU - Ginsberg, Jill
AU - Carlson, Claire
AU - Gracia, Clarisa
N1 - Funding Information:
This study was financially supported by grant nos. K01 L:1-CA-133839-03, 1R01HD062797 (CG), and T32-HD007440 (KC).
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Purpose: This study sought to evaluate the prevalence of menopausal symptoms in a population of reproductive-aged women remote from cancer therapy compared with a group of healthy similar-aged controls and with a cohort of late reproductive-aged (LR) controls. Methods: Participants were assessed for symptoms of menopause, early follicular phase hormones, and ultrasound examinations. Menopausal symptoms were analyzed in exposed participants and controls using χ2 analyses, Wilcoxon-Mann Whitney tests, and multivariable logistic regression models. Results: One hundred seventy cancer survivors, 135 similar-aged controls, and 71 LR controls were followed prospectively for an average of 38 months. Compared with similar-aged controls, a greater proportion of survivors reported vasomotor symptoms at some point over the study period (35% vs 19%, p < 0.01), and this proportion was similar to LR controls (44%, p = 0.22). Survivors were more likely to be bothered by vaginal dryness (27%) than similar-aged controls (16%, p = 0.02) or LR controls (14%, p = 0.02). FSH levels were 38.4% higher in those with vasomotor symptoms compared with those without symptoms (p = 0.021). Conclusions: Reproductive-aged cancer survivors have a higher prevalence of vasomotor symptoms and vaginal dryness than their similar-aged peers. Implications for Cancer Survivors: Providers should be attuned to the high prevalence of menopausal symptoms in cancer survivors.
AB - Purpose: This study sought to evaluate the prevalence of menopausal symptoms in a population of reproductive-aged women remote from cancer therapy compared with a group of healthy similar-aged controls and with a cohort of late reproductive-aged (LR) controls. Methods: Participants were assessed for symptoms of menopause, early follicular phase hormones, and ultrasound examinations. Menopausal symptoms were analyzed in exposed participants and controls using χ2 analyses, Wilcoxon-Mann Whitney tests, and multivariable logistic regression models. Results: One hundred seventy cancer survivors, 135 similar-aged controls, and 71 LR controls were followed prospectively for an average of 38 months. Compared with similar-aged controls, a greater proportion of survivors reported vasomotor symptoms at some point over the study period (35% vs 19%, p < 0.01), and this proportion was similar to LR controls (44%, p = 0.22). Survivors were more likely to be bothered by vaginal dryness (27%) than similar-aged controls (16%, p = 0.02) or LR controls (14%, p = 0.02). FSH levels were 38.4% higher in those with vasomotor symptoms compared with those without symptoms (p = 0.021). Conclusions: Reproductive-aged cancer survivors have a higher prevalence of vasomotor symptoms and vaginal dryness than their similar-aged peers. Implications for Cancer Survivors: Providers should be attuned to the high prevalence of menopausal symptoms in cancer survivors.
KW - Anti-Mullerian hormone
KW - Antral follicle count
KW - Menopause
KW - Vaginal dryness
KW - Vasomotor symptoms
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U2 - 10.1007/s11764-020-00857-z
DO - 10.1007/s11764-020-00857-z
M3 - Article
C2 - 32323140
AN - SCOPUS:85084147068
SN - 1932-2259
VL - 14
SP - 607
EP - 613
JO - Journal of Cancer Survivorship
JF - Journal of Cancer Survivorship
IS - 5
ER -