TY - JOUR
T1 - Relationship of low plasma klotho with poor grip strength in older community-dwelling adults
T2 - The InCHIANTI study
AU - Semba, Richard D.
AU - Cappola, Anne R.
AU - Sun, Kai
AU - Bandinelli, Stefania
AU - Dalal, Mansi
AU - Crasto, Candace
AU - Guralnik, Jack M.
AU - Ferrucci, Luigi
N1 - Funding Information:
Acknowledgments This work was supported by National Institute on Aging (NIA) Grant R01 AG027012, R01 HL094507, the Italian Ministry of Health (ICS110.1/RF97.71), NIA contracts 263 MD 9164, 263 MD 821336, N.1-AG-1-1, N.1-AG-1-2111, and N01-AG-5-0002, the Intramural Research Program of NIA, National Institutes of Health, Baltimore, Maryland.
PY - 2012/4
Y1 - 2012/4
N2 - Handgrip strength is a strong indicator of total body muscle strength and is a predictor of poor outcomes in older adults. The aging suppressor gene klotho encodes a single-pass transmembrane protein that is secreted as a circulating hormone. In mice, disruption of klotho expression results in a syndrome that includes sarcopenia, atherosclerosis, osteoporosis, and shortened lifespan, and conversely, overexpression of klotho leads to a greater longevity. The objective was to determine whether plasma klotho levels are related to skeletal muscle strength in humans. We measured plasma klotho in 804 adults, ≥65 years, in the InCHIANTI study, a longitudinal population-based study of aging in Tuscany, Italy. Grip strength was positively correlated with plasma klotho at threshold <681 pg/mL. After adjusting for age, sex, education, smoking, physical activity, cognition, and chronic diseases, plasma klotho (per 1 standard deviation increase) was associated with grip strength (beta = 1.20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength.
AB - Handgrip strength is a strong indicator of total body muscle strength and is a predictor of poor outcomes in older adults. The aging suppressor gene klotho encodes a single-pass transmembrane protein that is secreted as a circulating hormone. In mice, disruption of klotho expression results in a syndrome that includes sarcopenia, atherosclerosis, osteoporosis, and shortened lifespan, and conversely, overexpression of klotho leads to a greater longevity. The objective was to determine whether plasma klotho levels are related to skeletal muscle strength in humans. We measured plasma klotho in 804 adults, ≥65 years, in the InCHIANTI study, a longitudinal population-based study of aging in Tuscany, Italy. Grip strength was positively correlated with plasma klotho at threshold <681 pg/mL. After adjusting for age, sex, education, smoking, physical activity, cognition, and chronic diseases, plasma klotho (per 1 standard deviation increase) was associated with grip strength (beta = 1.20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength.
KW - Aging
KW - Klotho
KW - Muscle strength
KW - Sarcopenia
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U2 - 10.1007/s00421-011-2072-3
DO - 10.1007/s00421-011-2072-3
M3 - Article
C2 - 21769735
AN - SCOPUS:84861345426
SN - 1439-6319
VL - 112
SP - 1215
EP - 1220
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 4
ER -