TY - JOUR
T1 - Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia
T2 - The CORE320 multicenter study
AU - Kishi, Satoru
AU - Magalhaes, Tiago A.
AU - George, Richard T.
AU - Dewey, Marc
AU - Laham, Roger J.
AU - Niinuma, Hiroyuki
AU - Friedman, Lisa Aronson
AU - Cox, Christopher
AU - Tanami, Yutaka
AU - Schuijf, Joanne D.
AU - Vavere, Andrea L.
AU - Kitagawa, Kakuya
AU - Chen, Marcus Y.
AU - Nomura, Cesar H.
AU - Brinker, Jeffrey A.
AU - Rybicki, Frank J.
AU - Di Carli, Marcelo F.
AU - Arbab-Zadeh, Armin
AU - Lima, Joao A.C.
N1 - Publisher Copyright:
© The Author 2014.
PY - 2015/2
Y1 - 2015/2
N2 - Aims: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). Methods: Patients(n = 338) underwent 320 × 0.5 mmdetector row coronary computed tomography (CT) angiography, invasive and results coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysedto reflect quantitative total atheroma volume. LVM was measuredon myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score[SRS; oddsratio (OR), 1.07;95%confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. Conclusions: LVM was independently associated with the presence of coronary artery atherosclerosis and MI.
AB - Aims: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). Methods: Patients(n = 338) underwent 320 × 0.5 mmdetector row coronary computed tomography (CT) angiography, invasive and results coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysedto reflect quantitative total atheroma volume. LVM was measuredon myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score[SRS; oddsratio (OR), 1.07;95%confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. Conclusions: LVM was independently associated with the presence of coronary artery atherosclerosis and MI.
KW - Atheroma volume
KW - Coronary atherosclerosis
KW - Left ventricular mass
KW - Myocardial ischaemia
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U2 - 10.1093/ehjci/jeu217
DO - 10.1093/ehjci/jeu217
M3 - Article
C2 - 25368207
AN - SCOPUS:84945942460
SN - 2047-2404
VL - 16
SP - 166
EP - 176
JO - European heart journal cardiovascular Imaging
JF - European heart journal cardiovascular Imaging
IS - 2
ER -