Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: The CORE320 multicenter study

Satoru Kishi, Tiago A. Magalhaes, Richard T. George, Marc Dewey, Roger J. Laham, Hiroyuki Niinuma, Lisa Aronson Friedman, Christopher Cox, Yutaka Tanami, Joanne D. Schuijf, Andrea L. Vavere, Kakuya Kitagawa, Marcus Y. Chen, Cesar H. Nomura, Jeffrey A Brinker, Frank J. Rybicki, Marcelo F. Di Carli, Armin Zadeh, Joao Lima

Research output: Contribution to journalArticle

Abstract

Aims: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). Methods: Patients(n = 338) underwent 320 × 0.5 mmdetector row coronary computed tomography (CT) angiography, invasive and results coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysedto reflect quantitative total atheroma volume. LVM was measuredon myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score[SRS; oddsratio (OR), 1.07;95%confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. Conclusions: LVM was independently associated with the presence of coronary artery atherosclerosis and MI.

Original languageEnglish (US)
Pages (from-to)166-176
Number of pages11
JournalEuropean Heart Journal Cardiovascular Imaging
Volume16
Issue number2
DOIs
StatePublished - 2015

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Multicenter Studies
Myocardial Ischemia
Coronary Artery Disease
Atherosclerotic Plaques
Confidence Intervals
Myocardial Infarction
Coronary Angiography
Photons
Perfusion
Tomography
Myocardial Perfusion Imaging
Single-Photon Emission-Computed Tomography
Linear Models
Coronary Vessels
Pathologic Constriction
Logistic Models
Regression Analysis

Keywords

  • Atheroma volume
  • Coronary atherosclerosis
  • Left ventricular mass
  • Myocardial ischaemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia : The CORE320 multicenter study. / Kishi, Satoru; Magalhaes, Tiago A.; George, Richard T.; Dewey, Marc; Laham, Roger J.; Niinuma, Hiroyuki; Friedman, Lisa Aronson; Cox, Christopher; Tanami, Yutaka; Schuijf, Joanne D.; Vavere, Andrea L.; Kitagawa, Kakuya; Chen, Marcus Y.; Nomura, Cesar H.; Brinker, Jeffrey A; Rybicki, Frank J.; Di Carli, Marcelo F.; Zadeh, Armin; Lima, Joao.

In: European Heart Journal Cardiovascular Imaging, Vol. 16, No. 2, 2015, p. 166-176.

Research output: Contribution to journalArticle

Kishi, S, Magalhaes, TA, George, RT, Dewey, M, Laham, RJ, Niinuma, H, Friedman, LA, Cox, C, Tanami, Y, Schuijf, JD, Vavere, AL, Kitagawa, K, Chen, MY, Nomura, CH, Brinker, JA, Rybicki, FJ, Di Carli, MF, Zadeh, A & Lima, J 2015, 'Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: The CORE320 multicenter study', European Heart Journal Cardiovascular Imaging, vol. 16, no. 2, pp. 166-176. https://doi.org/10.1093/ehjci/jeu217
Kishi, Satoru ; Magalhaes, Tiago A. ; George, Richard T. ; Dewey, Marc ; Laham, Roger J. ; Niinuma, Hiroyuki ; Friedman, Lisa Aronson ; Cox, Christopher ; Tanami, Yutaka ; Schuijf, Joanne D. ; Vavere, Andrea L. ; Kitagawa, Kakuya ; Chen, Marcus Y. ; Nomura, Cesar H. ; Brinker, Jeffrey A ; Rybicki, Frank J. ; Di Carli, Marcelo F. ; Zadeh, Armin ; Lima, Joao. / Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia : The CORE320 multicenter study. In: European Heart Journal Cardiovascular Imaging. 2015 ; Vol. 16, No. 2. pp. 166-176.
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abstract = "Aims: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). Methods: Patients(n = 338) underwent 320 × 0.5 mmdetector row coronary computed tomography (CT) angiography, invasive and results coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysedto reflect quantitative total atheroma volume. LVM was measuredon myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50{\%} diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0{\%} of enrolled patients. LVMi was independently associated with abnormal summed rest score[SRS; oddsratio (OR), 1.07;95{\%}confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95{\%} CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95{\%} CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95{\%} CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. Conclusions: LVM was independently associated with the presence of coronary artery atherosclerosis and MI.",
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T1 - Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia

T2 - The CORE320 multicenter study

AU - Kishi, Satoru

AU - Magalhaes, Tiago A.

AU - George, Richard T.

AU - Dewey, Marc

AU - Laham, Roger J.

AU - Niinuma, Hiroyuki

AU - Friedman, Lisa Aronson

AU - Cox, Christopher

AU - Tanami, Yutaka

AU - Schuijf, Joanne D.

AU - Vavere, Andrea L.

AU - Kitagawa, Kakuya

AU - Chen, Marcus Y.

AU - Nomura, Cesar H.

AU - Brinker, Jeffrey A

AU - Rybicki, Frank J.

AU - Di Carli, Marcelo F.

AU - Zadeh, Armin

AU - Lima, Joao

PY - 2015

Y1 - 2015

N2 - Aims: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). Methods: Patients(n = 338) underwent 320 × 0.5 mmdetector row coronary computed tomography (CT) angiography, invasive and results coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysedto reflect quantitative total atheroma volume. LVM was measuredon myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score[SRS; oddsratio (OR), 1.07;95%confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. Conclusions: LVM was independently associated with the presence of coronary artery atherosclerosis and MI.

AB - Aims: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). Methods: Patients(n = 338) underwent 320 × 0.5 mmdetector row coronary computed tomography (CT) angiography, invasive and results coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysedto reflect quantitative total atheroma volume. LVM was measuredon myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score[SRS; oddsratio (OR), 1.07;95%confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. Conclusions: LVM was independently associated with the presence of coronary artery atherosclerosis and MI.

KW - Atheroma volume

KW - Coronary atherosclerosis

KW - Left ventricular mass

KW - Myocardial ischaemia

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