TY - JOUR
T1 - Relationship of dietary monounsaturated fatty acids to blood pressure
T2 - The international study of macro/micronutrients and blood pressure
AU - Miura, Katsuyuki
AU - Stamler, Jeremiah
AU - Brown, Ian J.
AU - Ueshima, Hirotsugu
AU - Nakagawa, Hideaki
AU - Sakurai, Masaru
AU - Chan, Queenie
AU - Appel, Lawrence J.
AU - Okayama, Akira
AU - Okuda, Nagako
AU - Curb, J. David
AU - Rodriguez, Beatriz L.
AU - Robertson, Claire
AU - Zhao, Liancheng
AU - Elliott, Paul
PY - 2013/6
Y1 - 2013/6
N2 - Objective: In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty acid intake of individuals with blood pressure in a cross-sectional study. Methods: The International Study of Macro/Micronutrients and Blood Pressure is a cross-sectional epidemiologic study of 4680 men and women ages 40-59 years from 17 population samples in China, Japan, UK and USA. Nutrient intake data were based on four in-depth multipass 24-h dietary recalls/person and two-timed 24-h urine collections/person. Blood pressure was measured eight times at four visits. Results: Mean monounsaturated fatty acid intake ranged from 8.1%kcal (China) to 12.2%kcal (USA). With sequential models to control for possible confounders (dietary, other), linear regression analyses showed significant inverse relationship of total monounsaturated fatty acid intake with DBP for all participants; for 2238 'nonintervened' individuals, the relationship was stronger. Estimated DBP differences with 2-SD higher monounsaturated fatty acids (5.35%kcal) were-0.82 mmHg (P < 0.05) for all participants and-1.70 mmHg (P < 0.01) for nonintervened individuals. Inverse associations of dietary total oleic acid (main monounsaturated) with blood pressure in nonintervened individuals were not significant, but those of oleic acid from vegetable sources were stronger and significant (P < 0.05). Conclusion: Dietary monounsaturated fatty acid intake, especially oleic acid from vegetable sources, may contribute to prevention and control of adverse blood pressure levels in general populations.
AB - Objective: In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty acid intake of individuals with blood pressure in a cross-sectional study. Methods: The International Study of Macro/Micronutrients and Blood Pressure is a cross-sectional epidemiologic study of 4680 men and women ages 40-59 years from 17 population samples in China, Japan, UK and USA. Nutrient intake data were based on four in-depth multipass 24-h dietary recalls/person and two-timed 24-h urine collections/person. Blood pressure was measured eight times at four visits. Results: Mean monounsaturated fatty acid intake ranged from 8.1%kcal (China) to 12.2%kcal (USA). With sequential models to control for possible confounders (dietary, other), linear regression analyses showed significant inverse relationship of total monounsaturated fatty acid intake with DBP for all participants; for 2238 'nonintervened' individuals, the relationship was stronger. Estimated DBP differences with 2-SD higher monounsaturated fatty acids (5.35%kcal) were-0.82 mmHg (P < 0.05) for all participants and-1.70 mmHg (P < 0.01) for nonintervened individuals. Inverse associations of dietary total oleic acid (main monounsaturated) with blood pressure in nonintervened individuals were not significant, but those of oleic acid from vegetable sources were stronger and significant (P < 0.05). Conclusion: Dietary monounsaturated fatty acid intake, especially oleic acid from vegetable sources, may contribute to prevention and control of adverse blood pressure levels in general populations.
KW - blood pressure
KW - monounsaturated fatty acids
KW - nutrition
KW - oleic acid
KW - population study
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U2 - 10.1097/HJH.0b013e3283604016
DO - 10.1097/HJH.0b013e3283604016
M3 - Article
C2 - 23572200
AN - SCOPUS:84877581192
SN - 0263-6352
VL - 31
SP - 1144
EP - 1150
JO - Journal of hypertension
JF - Journal of hypertension
IS - 6
ER -