Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function: The MESA-Right Ventricle Study

Michael O. Harhay, Russell P. Tracy, Emilia Bagiella, R. Graham Barr, Diane Pinder, W. Gregory Hundley, David A. Bluemke, Richard A. Kronmal, Joao Lima, Steven M. Kawut

Research output: Contribution to journalArticle

Abstract

Background/objectives Inflammation contributes to the pathogenesis of disease associated with the left ventricle (LV); yet, our understanding of the effect of inflammation on the right ventricle (RV) is quite limited. Methods and results The relationships of C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen with RV morphology and function (from cardiac MRI) were examined in participants free of clinical cardiovascular disease (n = 4009) from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study. Multivariable regressions (linear, quantile [25th and 75th] and generalized additive models [GAM]) were used to examine the independent association of CRP, IL-6 and fibrinogen with RV mass, RV end-diastolic volume (RVEDV), RV end-systolic volume (RVESV), RV stroke volume (RVSV) and RV ejection fraction (RVEF). Unadjusted and adjusted analyses revealed strong inverse associations between both CRP and IL-6 with RV mass, RVEDV, RVESV and RVSV (all p <0.01); there were no associations with RVEF. These relationships remained significant after adjustment for the respective LV parameters and lung function. However, GAM models suggested that extreme values of CRP and IL-6 might have positive associations with RV parameters. Fibrinogen showed significant associations in unadjusted models, but no associations after adjustment or in sensitivity analyses. Conclusion Levels of CRP and IL-6 are independently associated with RV morphology even after adjustment for the respective LV measure in this multi-ethnic population free of clinical cardiovascular disease. Systemic inflammation may contribute to RV structural changes independent of effects on the LV.

Original languageEnglish (US)
Pages (from-to)3818-3824
Number of pages7
JournalInternational Journal of Cardiology
Volume168
Issue number4
DOIs
StatePublished - Oct 9 2013

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Right Ventricular Function
C-Reactive Protein
Fibrinogen
Heart Ventricles
Interleukin-6
Atherosclerosis
Inflammation
Stroke Volume
Cardiovascular Diseases

Keywords

  • Heart failure
  • Multi-Ethnic Study of Atherosclerosis
  • Right ventricle
  • Systemic inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Harhay, M. O., Tracy, R. P., Bagiella, E., Barr, R. G., Pinder, D., Hundley, W. G., ... Kawut, S. M. (2013). Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function: The MESA-Right Ventricle Study. International Journal of Cardiology, 168(4), 3818-3824. https://doi.org/10.1016/j.ijcard.2013.06.028

Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function : The MESA-Right Ventricle Study. / Harhay, Michael O.; Tracy, Russell P.; Bagiella, Emilia; Barr, R. Graham; Pinder, Diane; Hundley, W. Gregory; Bluemke, David A.; Kronmal, Richard A.; Lima, Joao; Kawut, Steven M.

In: International Journal of Cardiology, Vol. 168, No. 4, 09.10.2013, p. 3818-3824.

Research output: Contribution to journalArticle

Harhay, MO, Tracy, RP, Bagiella, E, Barr, RG, Pinder, D, Hundley, WG, Bluemke, DA, Kronmal, RA, Lima, J & Kawut, SM 2013, 'Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function: The MESA-Right Ventricle Study', International Journal of Cardiology, vol. 168, no. 4, pp. 3818-3824. https://doi.org/10.1016/j.ijcard.2013.06.028
Harhay, Michael O. ; Tracy, Russell P. ; Bagiella, Emilia ; Barr, R. Graham ; Pinder, Diane ; Hundley, W. Gregory ; Bluemke, David A. ; Kronmal, Richard A. ; Lima, Joao ; Kawut, Steven M. / Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function : The MESA-Right Ventricle Study. In: International Journal of Cardiology. 2013 ; Vol. 168, No. 4. pp. 3818-3824.
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abstract = "Background/objectives Inflammation contributes to the pathogenesis of disease associated with the left ventricle (LV); yet, our understanding of the effect of inflammation on the right ventricle (RV) is quite limited. Methods and results The relationships of C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen with RV morphology and function (from cardiac MRI) were examined in participants free of clinical cardiovascular disease (n = 4009) from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study. Multivariable regressions (linear, quantile [25th and 75th] and generalized additive models [GAM]) were used to examine the independent association of CRP, IL-6 and fibrinogen with RV mass, RV end-diastolic volume (RVEDV), RV end-systolic volume (RVESV), RV stroke volume (RVSV) and RV ejection fraction (RVEF). Unadjusted and adjusted analyses revealed strong inverse associations between both CRP and IL-6 with RV mass, RVEDV, RVESV and RVSV (all p <0.01); there were no associations with RVEF. These relationships remained significant after adjustment for the respective LV parameters and lung function. However, GAM models suggested that extreme values of CRP and IL-6 might have positive associations with RV parameters. Fibrinogen showed significant associations in unadjusted models, but no associations after adjustment or in sensitivity analyses. Conclusion Levels of CRP and IL-6 are independently associated with RV morphology even after adjustment for the respective LV measure in this multi-ethnic population free of clinical cardiovascular disease. Systemic inflammation may contribute to RV structural changes independent of effects on the LV.",
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T1 - Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function

T2 - The MESA-Right Ventricle Study

AU - Harhay, Michael O.

AU - Tracy, Russell P.

AU - Bagiella, Emilia

AU - Barr, R. Graham

AU - Pinder, Diane

AU - Hundley, W. Gregory

AU - Bluemke, David A.

AU - Kronmal, Richard A.

AU - Lima, Joao

AU - Kawut, Steven M.

PY - 2013/10/9

Y1 - 2013/10/9

N2 - Background/objectives Inflammation contributes to the pathogenesis of disease associated with the left ventricle (LV); yet, our understanding of the effect of inflammation on the right ventricle (RV) is quite limited. Methods and results The relationships of C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen with RV morphology and function (from cardiac MRI) were examined in participants free of clinical cardiovascular disease (n = 4009) from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study. Multivariable regressions (linear, quantile [25th and 75th] and generalized additive models [GAM]) were used to examine the independent association of CRP, IL-6 and fibrinogen with RV mass, RV end-diastolic volume (RVEDV), RV end-systolic volume (RVESV), RV stroke volume (RVSV) and RV ejection fraction (RVEF). Unadjusted and adjusted analyses revealed strong inverse associations between both CRP and IL-6 with RV mass, RVEDV, RVESV and RVSV (all p <0.01); there were no associations with RVEF. These relationships remained significant after adjustment for the respective LV parameters and lung function. However, GAM models suggested that extreme values of CRP and IL-6 might have positive associations with RV parameters. Fibrinogen showed significant associations in unadjusted models, but no associations after adjustment or in sensitivity analyses. Conclusion Levels of CRP and IL-6 are independently associated with RV morphology even after adjustment for the respective LV measure in this multi-ethnic population free of clinical cardiovascular disease. Systemic inflammation may contribute to RV structural changes independent of effects on the LV.

AB - Background/objectives Inflammation contributes to the pathogenesis of disease associated with the left ventricle (LV); yet, our understanding of the effect of inflammation on the right ventricle (RV) is quite limited. Methods and results The relationships of C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen with RV morphology and function (from cardiac MRI) were examined in participants free of clinical cardiovascular disease (n = 4009) from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study. Multivariable regressions (linear, quantile [25th and 75th] and generalized additive models [GAM]) were used to examine the independent association of CRP, IL-6 and fibrinogen with RV mass, RV end-diastolic volume (RVEDV), RV end-systolic volume (RVESV), RV stroke volume (RVSV) and RV ejection fraction (RVEF). Unadjusted and adjusted analyses revealed strong inverse associations between both CRP and IL-6 with RV mass, RVEDV, RVESV and RVSV (all p <0.01); there were no associations with RVEF. These relationships remained significant after adjustment for the respective LV parameters and lung function. However, GAM models suggested that extreme values of CRP and IL-6 might have positive associations with RV parameters. Fibrinogen showed significant associations in unadjusted models, but no associations after adjustment or in sensitivity analyses. Conclusion Levels of CRP and IL-6 are independently associated with RV morphology even after adjustment for the respective LV measure in this multi-ethnic population free of clinical cardiovascular disease. Systemic inflammation may contribute to RV structural changes independent of effects on the LV.

KW - Heart failure

KW - Multi-Ethnic Study of Atherosclerosis

KW - Right ventricle

KW - Systemic inflammation

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