Relationship of cognitive functioning, whole brain volumes, and T2- weighted hyperintensities in neurofibromatosis-1

Laurie E. Cutting, Christine W. Koth, Courtney P. Burnette, Michael T. Abrams, Walter E. Kaufmann, Martha Bridge Denckla

Research output: Contribution to journalArticle

Abstract

Using quantitative magnetic resonance imaging morphometry, we report that the whole brain volumes of patients with neurofibromatosis-1 are significantly larger than normal, confirm the prevalence of macrocephaly as about 50%, and report that macrocephaly in patients with neurofibromatosis-1 does not appear to be related to the familial or sporadic origin of the neurofibromatosis-1 or to the presence or absence of T2-weighted hyperintensities. No strong relationship emerged between the extent of neurofibromatosis-1-associated impairment of cognitive functions and degree of macrocephaly; however, the macrocephalic neurofibromatosis-1 group did have a significant verbal impairment relative to the non-macrocephalic neurofibromatosis-1 group in vocabulary (P <.009).

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalJournal of Child Neurology
Volume15
Issue number3
StatePublished - Mar 2000

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Neurofibromatosis 1
Megalencephaly
Brain
Vocabulary
Cognition
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Relationship of cognitive functioning, whole brain volumes, and T2- weighted hyperintensities in neurofibromatosis-1. / Cutting, Laurie E.; Koth, Christine W.; Burnette, Courtney P.; Abrams, Michael T.; Kaufmann, Walter E.; Denckla, Martha Bridge.

In: Journal of Child Neurology, Vol. 15, No. 3, 03.2000, p. 157-160.

Research output: Contribution to journalArticle

Cutting, Laurie E. ; Koth, Christine W. ; Burnette, Courtney P. ; Abrams, Michael T. ; Kaufmann, Walter E. ; Denckla, Martha Bridge. / Relationship of cognitive functioning, whole brain volumes, and T2- weighted hyperintensities in neurofibromatosis-1. In: Journal of Child Neurology. 2000 ; Vol. 15, No. 3. pp. 157-160.
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