Abstract
Using quantitative magnetic resonance imaging morphometry, we report that the whole brain volumes of patients with neurofibromatosis-1 are significantly larger than normal, confirm the prevalence of macrocephaly as about 50%, and report that macrocephaly in patients with neurofibromatosis-1 does not appear to be related to the familial or sporadic origin of the neurofibromatosis-1 or to the presence or absence of T2-weighted hyperintensities. No strong relationship emerged between the extent of neurofibromatosis-1-associated impairment of cognitive functions and degree of macrocephaly; however, the macrocephalic neurofibromatosis-1 group did have a significant verbal impairment relative to the non-macrocephalic neurofibromatosis-1 group in vocabulary (P < .009).
Original language | English (US) |
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Pages (from-to) | 157-160 |
Number of pages | 4 |
Journal | Journal of child neurology |
Volume | 15 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2000 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology