Relationship of cognitive functioning, whole brain volumes, and T2- weighted hyperintensities in neurofibromatosis-1

Laurie E. Cutting, Christine W. Koth, Courtney P. Burnette, Michael T. Abrams, Walter E. Kaufmann, Martha Bridge Denckla

Research output: Contribution to journalArticlepeer-review


Using quantitative magnetic resonance imaging morphometry, we report that the whole brain volumes of patients with neurofibromatosis-1 are significantly larger than normal, confirm the prevalence of macrocephaly as about 50%, and report that macrocephaly in patients with neurofibromatosis-1 does not appear to be related to the familial or sporadic origin of the neurofibromatosis-1 or to the presence or absence of T2-weighted hyperintensities. No strong relationship emerged between the extent of neurofibromatosis-1-associated impairment of cognitive functions and degree of macrocephaly; however, the macrocephalic neurofibromatosis-1 group did have a significant verbal impairment relative to the non-macrocephalic neurofibromatosis-1 group in vocabulary (P < .009).

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalJournal of child neurology
Issue number3
StatePublished - Mar 2000

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


Dive into the research topics of 'Relationship of cognitive functioning, whole brain volumes, and T<sub>2</sub>- weighted hyperintensities in neurofibromatosis-1'. Together they form a unique fingerprint.

Cite this