Relationship of cognitive and functional impairment to depressive features in Alzheimer's disease and other dementias

Jennifer L. Payne, Constantine G. Lyketsos, Cynthia Steele, Lori Baker, Elizabeth Galik, Susan Kopunek, Martin Steinberg, Andrew Warren

Research output: Contribution to journalArticle

Abstract

Patients with clinical diagnoses of Alzheimer's disease, vascular dementia, or undifferentiated dementia were rated on standardized measures of depression, cognitive impairment, and functional impairment. Logistic regression was used to evaluate the relationship between functional or cognitive impairment, as well as their interaction, and depressive features in each group. This analysis revealed notable differences by type of dementia. The results imply that the mechanisms underlying depression in Alzheimer's disease may be different from those in vascular and other types of dementia. These results also provide indicators to the clinician for further evaluation of depression in different dementia subtypes.

Original languageEnglish (US)
Pages (from-to)440-447
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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