Relationship of cardiac allograft size and pulmonary vascular resistance to long-term cardiopulmonary function

T. K. Yeoh, W. H. Frist, C. Lagerstrom, Edward K Kasper, J. Groves, W. Merrill

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to evaluate the long-term cardiopulmonary function of heart transplant patients who received disproportionately sized allografts for varying levels of pulmonary vascular resistance. Resting hemodynamics and oxygen uptake during exercise were recorded at 1 year after transplantation in 52 patients. No differences in resting heart rate, cardiac output, stroke volume, peak oxygen uptake during exercise, and exercise duration were found in recipients of undersized hearts (donor:recipient weight ratio [D:R] 1.25) hearts. In a further analysis according to preoperative pulmonary vascular resistance, resting cardiac output (5.8±1.3L/min) was normal, and peak exercise oxygen uptake (22.7±8.0ml/kg/min) was mildly decreased in recipients of size-matched allografts with a pulmonary vascular resistance of less than 3 Wood units (size-matched hearts, with mild or no pulmonary vascular resistance). Of patients with moderate pulmonary hypertension (pulmonary vascular resistance ≥3 Wood units), resting cardiac output was normal (5.1±0.6L/min) in recipients of oversized hearts and was reduced (4.7±1.0L/min) in recipients of size-matched hearts (p

Original languageEnglish (US)
Pages (from-to)1168-1176
Number of pages9
JournalJournal of Heart and Lung Transplantation
Volume11
Issue number6
StatePublished - 1992
Externally publishedYes

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Vascular Resistance
Allografts
Cardiac Output
Exercise
Oxygen
Pulmonary Hypertension
Stroke Volume
Transplantation
Heart Rate
Hemodynamics
Tissue Donors
Transplants
Weights and Measures

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Relationship of cardiac allograft size and pulmonary vascular resistance to long-term cardiopulmonary function. / Yeoh, T. K.; Frist, W. H.; Lagerstrom, C.; Kasper, Edward K; Groves, J.; Merrill, W.

In: Journal of Heart and Lung Transplantation, Vol. 11, No. 6, 1992, p. 1168-1176.

Research output: Contribution to journalArticle

Yeoh, T. K. ; Frist, W. H. ; Lagerstrom, C. ; Kasper, Edward K ; Groves, J. ; Merrill, W. / Relationship of cardiac allograft size and pulmonary vascular resistance to long-term cardiopulmonary function. In: Journal of Heart and Lung Transplantation. 1992 ; Vol. 11, No. 6. pp. 1168-1176.
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