TY - JOUR
T1 - Relationship of Body Mass Index and Waist Circumference With Risk of New-Onset Proteinuria in Hypertensive Patients
AU - Liu, Mengyi
AU - Zhang, Zhuxian
AU - Zhou, Chun
AU - He, Panpan
AU - Nie, Jing
AU - Liang, Min
AU - Liu, Chengzhang
AU - Xu, Fanghua
AU - Liao, Guangzhou
AU - Zhang, Yan
AU - Li, Jianping
AU - Wang, Binyan
AU - Wang, Xiaobin
AU - Huo, Yong
AU - Xu, Xiping
AU - Qin, Xianhui
N1 - Funding Information:
Financial Support: The study was supported by the
Funding Information:
National Key Research and Development Program, of China (2016YFE0205400, 2018ZX09739010, 2018ZX09301034003), the Science and Technology Planning Project of Guangzhou, China (201707020010); Science, Technology and Innovation Committee of Shenzhen, of China (JSGG20170412155639040, GJHS20170314114526143, JSGG20180703155802047); the Economic, Trade and Information Commission of Shenzhen Municipality, of China (20170505161556110, 20170505160926390); the National Natural Science Foundation of China (81973133,81730019); Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University, of China [2017J009].
Publisher Copyright:
© 2020 Endocrine Society 2020.
PY - 2020/1/8
Y1 - 2020/1/8
N2 - Context: The association of the combination of body mass index (BMI) and waist circumference (WC) with the risk of proteinuria has previously not been comprehensively investigated and results have been inconclusive. Objective: To examine BMI and WC in relation to new-onset proteinuria in Chinese hypertensive patients. Design and Setting: Post hoc analysis of the renal substudy of the China Stroke Primary Prevention Trial (CSPPT). Patients: 10 805 hypertensive patients without proteinuria at baseline. Main Outcome Measure: The primary outcome was new-onset proteinuria, defined as a urine dipstick protein reading ≥ 1 + at the exit visit, after a median follow-up duration of 4.4 years. Results: When analyzed separately, increased BMI (≥ 28 kg/m2, quartile 4; odds ratio [OR], 1.36; 95% confidence interval [CI], 1.08-1.72), or increased WC (≥ 91cm for females, quartile 4; OR, 1.35; 95% CI, 1.01-1.80; and ≥ 79 cm for males, quartile 2-4; OR, 1.60; 95% CI, 1.03-2.50) were each significantly associated with higher risk of new-onset proteinuria. When analyzed jointly, participants without increased BMI and increased WC had the lowest risk, while those with both increased BMI and increased WC had the highest risk of proteinuria (OR, 1.61; 95% CI, 1.21-2.13). Notably, participants with only increased WC also had significantly increased risk of proteinuria (OR, 1.39; 95% CI, 1.04-1.85). Conclusion: In Chinese hypertensive patients, increased BMI and increased WC were individually and jointly associated with a higher risk of new-onset proteinuria, underscoring the value of monitoring both BMI and WC in assessing proteinuria risk.
AB - Context: The association of the combination of body mass index (BMI) and waist circumference (WC) with the risk of proteinuria has previously not been comprehensively investigated and results have been inconclusive. Objective: To examine BMI and WC in relation to new-onset proteinuria in Chinese hypertensive patients. Design and Setting: Post hoc analysis of the renal substudy of the China Stroke Primary Prevention Trial (CSPPT). Patients: 10 805 hypertensive patients without proteinuria at baseline. Main Outcome Measure: The primary outcome was new-onset proteinuria, defined as a urine dipstick protein reading ≥ 1 + at the exit visit, after a median follow-up duration of 4.4 years. Results: When analyzed separately, increased BMI (≥ 28 kg/m2, quartile 4; odds ratio [OR], 1.36; 95% confidence interval [CI], 1.08-1.72), or increased WC (≥ 91cm for females, quartile 4; OR, 1.35; 95% CI, 1.01-1.80; and ≥ 79 cm for males, quartile 2-4; OR, 1.60; 95% CI, 1.03-2.50) were each significantly associated with higher risk of new-onset proteinuria. When analyzed jointly, participants without increased BMI and increased WC had the lowest risk, while those with both increased BMI and increased WC had the highest risk of proteinuria (OR, 1.61; 95% CI, 1.21-2.13). Notably, participants with only increased WC also had significantly increased risk of proteinuria (OR, 1.39; 95% CI, 1.04-1.85). Conclusion: In Chinese hypertensive patients, increased BMI and increased WC were individually and jointly associated with a higher risk of new-onset proteinuria, underscoring the value of monitoring both BMI and WC in assessing proteinuria risk.
KW - BMI
KW - hypertensive patients
KW - new-onset proteinuria
KW - waist circumference
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U2 - 10.1210/clinem/dgaa026
DO - 10.1210/clinem/dgaa026
M3 - Article
C2 - 31976527
AN - SCOPUS:85079318645
VL - 105
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 3
M1 - dgaa026
ER -