Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults: The baltimore longitudinal study of aging

Richard David Semba, J. Beck, K. Sun, J. M. Egan, O. D. Carlson, Ravi Varadhan, L. Ferrucci

Research output: Contribution to journalArticle

Abstract

Background and Objectives: Although hyperglycemia is thought to increase the generation of advanced glycation end products (AGEs), studies have not shown a consistent relationship between abnormal glucose metabolism and serum AGEs. We investigated the relationship between a dominant serum AGE, Ncarboxymethyl-lysine (CML), and glucose metabolism. Subjects and Methods: Serum CML, fasting plasma glucose, and glucose tolerance were measured in 755 adults in the Baltimore Longitudinal Study of Aging. Fasting plasma glucose was categorized as normal (≤99 mg/dL), impaired (100-125 mg/dL), and diabetic (>125 mg/dL). Two-hour plasma glucose on oral glucose tolerance testing was categorized as normal (≤139 mg/dL), impaired (140-199 mg/dL), and diabetic (≥200 mg/dL). Results: The proportion of adults with normal, impaired, and diabetic fasting plasma glucose was 73.8%, 22.9%, and 2.9%, respectively, and the proportion with normal, impaired, and diabetic 2-hour plasma glucose was 73.1%, 19.2%, and 7.7%, respectively. Serum CML ( g/mL) was not associated with abnormal fasting plasma glucose (Odds Ratio [O.R.] 0.60, 95% Confidence Interval [C.I.] 0.15-2.36, P = 0.47) in a multivariate, ordered logistic regression model, adjusting for age, race, gender, body mass index, and chronic diseases. Serum CML ( g/mL) was associated with abnormal 2-hour plasma glucose on glucose tolerance testing (O.R. 0.15, 95% C.I. 0.04-0.63, P = 0.009) in a multivariate, ordered logistic regression model, adjusting for the same covariates. Conclusions: Elevated CML, a dominant AGE, was not associated with elevated fasting plasma glucose and was associated with a reduced odds of abnormal glucose tolerance in older community-dwelling adults.

Original languageEnglish (US)
Pages (from-to)507-513
Number of pages7
JournalThe journal of nutrition, health & aging
Volume14
Issue number7
DOIs
StatePublished - Jul 2010

Fingerprint

Baltimore
Advanced Glycosylation End Products
Longitudinal Studies
Glucose
Serum
Fasting
Logistic Models
N(6)-carboxymethyllysine
Odds Ratio
Confidence Intervals
Independent Living
Glucose Tolerance Test
Hyperglycemia
Lysine

Keywords

  • Advanced glycation end products
  • aging
  • diabetes
  • glucose tolerance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

@article{e59d81a5243c4274b3d8867074e2f77e,
title = "Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults: The baltimore longitudinal study of aging",
abstract = "Background and Objectives: Although hyperglycemia is thought to increase the generation of advanced glycation end products (AGEs), studies have not shown a consistent relationship between abnormal glucose metabolism and serum AGEs. We investigated the relationship between a dominant serum AGE, Ncarboxymethyl-lysine (CML), and glucose metabolism. Subjects and Methods: Serum CML, fasting plasma glucose, and glucose tolerance were measured in 755 adults in the Baltimore Longitudinal Study of Aging. Fasting plasma glucose was categorized as normal (≤99 mg/dL), impaired (100-125 mg/dL), and diabetic (>125 mg/dL). Two-hour plasma glucose on oral glucose tolerance testing was categorized as normal (≤139 mg/dL), impaired (140-199 mg/dL), and diabetic (≥200 mg/dL). Results: The proportion of adults with normal, impaired, and diabetic fasting plasma glucose was 73.8{\%}, 22.9{\%}, and 2.9{\%}, respectively, and the proportion with normal, impaired, and diabetic 2-hour plasma glucose was 73.1{\%}, 19.2{\%}, and 7.7{\%}, respectively. Serum CML ( g/mL) was not associated with abnormal fasting plasma glucose (Odds Ratio [O.R.] 0.60, 95{\%} Confidence Interval [C.I.] 0.15-2.36, P = 0.47) in a multivariate, ordered logistic regression model, adjusting for age, race, gender, body mass index, and chronic diseases. Serum CML ( g/mL) was associated with abnormal 2-hour plasma glucose on glucose tolerance testing (O.R. 0.15, 95{\%} C.I. 0.04-0.63, P = 0.009) in a multivariate, ordered logistic regression model, adjusting for the same covariates. Conclusions: Elevated CML, a dominant AGE, was not associated with elevated fasting plasma glucose and was associated with a reduced odds of abnormal glucose tolerance in older community-dwelling adults.",
keywords = "Advanced glycation end products, aging, diabetes, glucose tolerance",
author = "Semba, {Richard David} and J. Beck and K. Sun and Egan, {J. M.} and Carlson, {O. D.} and Ravi Varadhan and L. Ferrucci",
year = "2010",
month = "7",
doi = "10.1007/s12603-010-0105-y",
language = "English (US)",
volume = "14",
pages = "507--513",
journal = "Journal of Nutrition, Health and Aging",
issn = "1279-7707",
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TY - JOUR

T1 - Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults

T2 - The baltimore longitudinal study of aging

AU - Semba, Richard David

AU - Beck, J.

AU - Sun, K.

AU - Egan, J. M.

AU - Carlson, O. D.

AU - Varadhan, Ravi

AU - Ferrucci, L.

PY - 2010/7

Y1 - 2010/7

N2 - Background and Objectives: Although hyperglycemia is thought to increase the generation of advanced glycation end products (AGEs), studies have not shown a consistent relationship between abnormal glucose metabolism and serum AGEs. We investigated the relationship between a dominant serum AGE, Ncarboxymethyl-lysine (CML), and glucose metabolism. Subjects and Methods: Serum CML, fasting plasma glucose, and glucose tolerance were measured in 755 adults in the Baltimore Longitudinal Study of Aging. Fasting plasma glucose was categorized as normal (≤99 mg/dL), impaired (100-125 mg/dL), and diabetic (>125 mg/dL). Two-hour plasma glucose on oral glucose tolerance testing was categorized as normal (≤139 mg/dL), impaired (140-199 mg/dL), and diabetic (≥200 mg/dL). Results: The proportion of adults with normal, impaired, and diabetic fasting plasma glucose was 73.8%, 22.9%, and 2.9%, respectively, and the proportion with normal, impaired, and diabetic 2-hour plasma glucose was 73.1%, 19.2%, and 7.7%, respectively. Serum CML ( g/mL) was not associated with abnormal fasting plasma glucose (Odds Ratio [O.R.] 0.60, 95% Confidence Interval [C.I.] 0.15-2.36, P = 0.47) in a multivariate, ordered logistic regression model, adjusting for age, race, gender, body mass index, and chronic diseases. Serum CML ( g/mL) was associated with abnormal 2-hour plasma glucose on glucose tolerance testing (O.R. 0.15, 95% C.I. 0.04-0.63, P = 0.009) in a multivariate, ordered logistic regression model, adjusting for the same covariates. Conclusions: Elevated CML, a dominant AGE, was not associated with elevated fasting plasma glucose and was associated with a reduced odds of abnormal glucose tolerance in older community-dwelling adults.

AB - Background and Objectives: Although hyperglycemia is thought to increase the generation of advanced glycation end products (AGEs), studies have not shown a consistent relationship between abnormal glucose metabolism and serum AGEs. We investigated the relationship between a dominant serum AGE, Ncarboxymethyl-lysine (CML), and glucose metabolism. Subjects and Methods: Serum CML, fasting plasma glucose, and glucose tolerance were measured in 755 adults in the Baltimore Longitudinal Study of Aging. Fasting plasma glucose was categorized as normal (≤99 mg/dL), impaired (100-125 mg/dL), and diabetic (>125 mg/dL). Two-hour plasma glucose on oral glucose tolerance testing was categorized as normal (≤139 mg/dL), impaired (140-199 mg/dL), and diabetic (≥200 mg/dL). Results: The proportion of adults with normal, impaired, and diabetic fasting plasma glucose was 73.8%, 22.9%, and 2.9%, respectively, and the proportion with normal, impaired, and diabetic 2-hour plasma glucose was 73.1%, 19.2%, and 7.7%, respectively. Serum CML ( g/mL) was not associated with abnormal fasting plasma glucose (Odds Ratio [O.R.] 0.60, 95% Confidence Interval [C.I.] 0.15-2.36, P = 0.47) in a multivariate, ordered logistic regression model, adjusting for age, race, gender, body mass index, and chronic diseases. Serum CML ( g/mL) was associated with abnormal 2-hour plasma glucose on glucose tolerance testing (O.R. 0.15, 95% C.I. 0.04-0.63, P = 0.009) in a multivariate, ordered logistic regression model, adjusting for the same covariates. Conclusions: Elevated CML, a dominant AGE, was not associated with elevated fasting plasma glucose and was associated with a reduced odds of abnormal glucose tolerance in older community-dwelling adults.

KW - Advanced glycation end products

KW - aging

KW - diabetes

KW - glucose tolerance

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