TY - JOUR
T1 - Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults
T2 - The baltimore longitudinal study of aging
AU - Semba, Richard D.
AU - Beck, J.
AU - Sun, K.
AU - Egan, J. M.
AU - Carlson, O. D.
AU - Varadhan, R.
AU - Ferrucci, L.
N1 - Funding Information:
Grant Support: This work was supported by National Institute on Aging Grant R01
Funding Information:
AG027012, R01 AG029148, and the Intramural Research Program, National Institute on Aging, NIH.
PY - 2010/7
Y1 - 2010/7
N2 - Background and Objectives: Although hyperglycemia is thought to increase the generation of advanced glycation end products (AGEs), studies have not shown a consistent relationship between abnormal glucose metabolism and serum AGEs. We investigated the relationship between a dominant serum AGE, Ncarboxymethyl-lysine (CML), and glucose metabolism. Subjects and Methods: Serum CML, fasting plasma glucose, and glucose tolerance were measured in 755 adults in the Baltimore Longitudinal Study of Aging. Fasting plasma glucose was categorized as normal (≤99 mg/dL), impaired (100-125 mg/dL), and diabetic (>125 mg/dL). Two-hour plasma glucose on oral glucose tolerance testing was categorized as normal (≤139 mg/dL), impaired (140-199 mg/dL), and diabetic (≥200 mg/dL). Results: The proportion of adults with normal, impaired, and diabetic fasting plasma glucose was 73.8%, 22.9%, and 2.9%, respectively, and the proportion with normal, impaired, and diabetic 2-hour plasma glucose was 73.1%, 19.2%, and 7.7%, respectively. Serum CML ( g/mL) was not associated with abnormal fasting plasma glucose (Odds Ratio [O.R.] 0.60, 95% Confidence Interval [C.I.] 0.15-2.36, P = 0.47) in a multivariate, ordered logistic regression model, adjusting for age, race, gender, body mass index, and chronic diseases. Serum CML ( g/mL) was associated with abnormal 2-hour plasma glucose on glucose tolerance testing (O.R. 0.15, 95% C.I. 0.04-0.63, P = 0.009) in a multivariate, ordered logistic regression model, adjusting for the same covariates. Conclusions: Elevated CML, a dominant AGE, was not associated with elevated fasting plasma glucose and was associated with a reduced odds of abnormal glucose tolerance in older community-dwelling adults.
AB - Background and Objectives: Although hyperglycemia is thought to increase the generation of advanced glycation end products (AGEs), studies have not shown a consistent relationship between abnormal glucose metabolism and serum AGEs. We investigated the relationship between a dominant serum AGE, Ncarboxymethyl-lysine (CML), and glucose metabolism. Subjects and Methods: Serum CML, fasting plasma glucose, and glucose tolerance were measured in 755 adults in the Baltimore Longitudinal Study of Aging. Fasting plasma glucose was categorized as normal (≤99 mg/dL), impaired (100-125 mg/dL), and diabetic (>125 mg/dL). Two-hour plasma glucose on oral glucose tolerance testing was categorized as normal (≤139 mg/dL), impaired (140-199 mg/dL), and diabetic (≥200 mg/dL). Results: The proportion of adults with normal, impaired, and diabetic fasting plasma glucose was 73.8%, 22.9%, and 2.9%, respectively, and the proportion with normal, impaired, and diabetic 2-hour plasma glucose was 73.1%, 19.2%, and 7.7%, respectively. Serum CML ( g/mL) was not associated with abnormal fasting plasma glucose (Odds Ratio [O.R.] 0.60, 95% Confidence Interval [C.I.] 0.15-2.36, P = 0.47) in a multivariate, ordered logistic regression model, adjusting for age, race, gender, body mass index, and chronic diseases. Serum CML ( g/mL) was associated with abnormal 2-hour plasma glucose on glucose tolerance testing (O.R. 0.15, 95% C.I. 0.04-0.63, P = 0.009) in a multivariate, ordered logistic regression model, adjusting for the same covariates. Conclusions: Elevated CML, a dominant AGE, was not associated with elevated fasting plasma glucose and was associated with a reduced odds of abnormal glucose tolerance in older community-dwelling adults.
KW - Advanced glycation end products
KW - aging
KW - diabetes
KW - glucose tolerance
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U2 - 10.1007/s12603-010-0105-y
DO - 10.1007/s12603-010-0105-y
M3 - Article
C2 - 20818463
AN - SCOPUS:77957941778
SN - 1279-7707
VL - 14
SP - 507
EP - 513
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
IS - 7
ER -