Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults

Richard David Semba, D. K. Houston, S. Bandinelli, K. Sun, A. Cherubini, A. R. Cappola, J. M. Guralnik, L. Ferrucci

Research output: Contribution to journalArticle

Abstract

Background/Objectives: Vitamin D deficiency is associated with cardiovascular disease, osteoporosis, poor muscle strength, falls, fractures and mortality. Although older adults are at a higher risk of vitamin D deficiency, the relationship of serum 25-hydroxyvitamin D (25(OH)D) with all-cause and cardiovascular disease mortality has not been well characterized in the elderly. We hypothesized that low serum 25(OH)D levels predicted mortality in older adults.Subjects/Methods: Serum 25(OH)D as well as all-cause and cardiovascular disease mortality were examined in 1006 adults, aged ≥65 years, who participated in the InCHIANTI (Invecchiare in Chianti, Aging in the Chianti Area) study, a population-based, prospective cohort study of aging in Tuscany, Italy. Serum 25(OH)D levels were measured at the time of enrollment in 1998-1999, and participants were followed up for mortality. Results: During 6.5 years of follow-up, 228 (22.7%) participants died, of whom 107 died due to cardiovascular diseases. Compared with participants in the highest quartile of serum 25(OH)D (>26.5 ng/ml) (to convert to nmol/l, multiply by 2.496), those in the lowest quartile (

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalEuropean Journal of Clinical Nutrition
Volume64
Issue number2
DOIs
StatePublished - Feb 2010

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Independent Living
Cardiovascular Diseases
Mortality
Serum
Vitamin D Deficiency
Muscle Strength
Italy
Osteoporosis
Cohort Studies
25-hydroxyvitamin D
Prospective Studies
Population

Keywords

  • Aging
  • All-cause mortality
  • Cardiovascular disease mortality
  • Vitamin D

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults. / Semba, Richard David; Houston, D. K.; Bandinelli, S.; Sun, K.; Cherubini, A.; Cappola, A. R.; Guralnik, J. M.; Ferrucci, L.

In: European Journal of Clinical Nutrition, Vol. 64, No. 2, 02.2010, p. 203-209.

Research output: Contribution to journalArticle

Semba, Richard David ; Houston, D. K. ; Bandinelli, S. ; Sun, K. ; Cherubini, A. ; Cappola, A. R. ; Guralnik, J. M. ; Ferrucci, L. / Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults. In: European Journal of Clinical Nutrition. 2010 ; Vol. 64, No. 2. pp. 203-209.
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