Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America

Horacio A. Duarte, Donald Robert Harris, Katherine Tassiopoulos, Erin Leister, Silvia Fabiana Biason de Moura Negrini, Flávia Faleiro Ferreira, Maria Letícia Santos Cruz, Jorge Pinto, Susannah Allison, Rohan Hazra, Jorge A. Pinto, Flávia F. Faleiro, Marcelle M. Maia, Rosa Dea Sperhacke, Nicole Golin, Sílvia Mariani Costamilan, Jose Pilotto, Luis Felipe Moreira, Ivete Gomes, Breno Riegel SantosRita de Cassia Alves Lira, Mario Ferreira Peixoto, Elizabete Teles, Marcelo Goldani, Carmem Lúcia Oliveira da Silva, Margery Bohrer Zanetello, Regis Kreitchmann, Marcelo Comerlato Scotta, Debora Fernandes Coelho, Marisa M. Mussi-Pinhata, Maria Célia Cervi, Márcia L. Isaac, Fernanda Tomé Sturzbecher, Bento V. Moura Negrini, Ricardo Hugo S Oliveira, Maria C. Chermont Sapia, Esau Custodio Joao, Maria Leticia Cruz, Leon Claude Sidi, Maria Isabel Gouvêa, Mariza Curto Saavedra, Clarisse Bressan, Fernanda Cavalcanti A Jundi, Regina Celia de Menezes Succi, Daisy Maria Machado, Marinella Della Negra, Wladimir Queiroz, Yu Ching Lian, Noris Pavía-Ruz, Dulce Morales-Pérez, Karla Ojeda-Diezbarroso, Jorge O. Alarcón Villaverde, María Castillo Díaz, Yolanda Bertucci, Laura Freimanis Hance, Gonin René Gonin, D. Robert Harris, Roslyn Hennessey, Margot Krauss, Sue Li, Karen Megazzini, Orlando Ortega, James Korelitz, Sharon Sothern de Sanchez, Sonia K. Stoszek, Qilu Yu, Lynne M. Mofenson, George K. Siberry

Research output: Contribution to journalArticle

Abstract

Few studies have examined antiretroviral therapy adherence in Latin American children. Standardized behavioral measures were applied to a large cohort of human immunodeficiency virus-infected children in Brazil, Mexico, and Peru to assess adherence to prescribed antiretroviral therapy doses during the three days prior to study visits, assess timing of last missed dose, and evaluate the ability of the adherence measures to predict viral suppression. Time trends in adherence were modeled using a generalized estimating equations approach to account for possible correlations in outcomes measured repeatedly in the same participants. Associations of adherence with human immunodeficiency virus viral load were examined using linear regression. Mean enrollment age of the 380 participants was 5 years; 57.6% had undetectable' viral load (. 0.3). Last time missed any antiretroviral therapy dose was reported as "never" for 52.0% at enrollment, increasing to 60.7% and 65.9% at the 6- and 12-month visits, respectively ( p

Original languageEnglish (US)
Pages (from-to)263-271
Number of pages9
JournalBrazilian Journal of Infectious Diseases
Volume19
Issue number3
DOIs
StatePublished - May 1 2015
Externally publishedYes

Fingerprint

Latin America
Viral Load
HIV
Peru
Mexico
Brazil
Linear Models
Therapeutics

Keywords

  • Adherence
  • ART
  • Latin America
  • Pediatric

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America. / Duarte, Horacio A.; Harris, Donald Robert; Tassiopoulos, Katherine; Leister, Erin; Negrini, Silvia Fabiana Biason de Moura; Ferreira, Flávia Faleiro; Cruz, Maria Letícia Santos; Pinto, Jorge; Allison, Susannah; Hazra, Rohan; Pinto, Jorge A.; Faleiro, Flávia F.; Maia, Marcelle M.; Sperhacke, Rosa Dea; Golin, Nicole; Costamilan, Sílvia Mariani; Pilotto, Jose; Moreira, Luis Felipe; Gomes, Ivete; Santos, Breno Riegel; de Cassia Alves Lira, Rita; Peixoto, Mario Ferreira; Teles, Elizabete; Goldani, Marcelo; da Silva, Carmem Lúcia Oliveira; Zanetello, Margery Bohrer; Kreitchmann, Regis; Scotta, Marcelo Comerlato; Coelho, Debora Fernandes; Mussi-Pinhata, Marisa M.; Cervi, Maria Célia; Isaac, Márcia L.; Sturzbecher, Fernanda Tomé; Moura Negrini, Bento V.; Oliveira, Ricardo Hugo S; Chermont Sapia, Maria C.; Joao, Esau Custodio; Cruz, Maria Leticia; Sidi, Leon Claude; Gouvêa, Maria Isabel; Saavedra, Mariza Curto; Bressan, Clarisse; Jundi, Fernanda Cavalcanti A; de Menezes Succi, Regina Celia; Machado, Daisy Maria; Negra, Marinella Della; Queiroz, Wladimir; Lian, Yu Ching; Pavía-Ruz, Noris; Morales-Pérez, Dulce; Ojeda-Diezbarroso, Karla; Alarcón Villaverde, Jorge O.; Díaz, María Castillo; Bertucci, Yolanda; Hance, Laura Freimanis; René Gonin, Gonin; Robert Harris, D.; Hennessey, Roslyn; Krauss, Margot; Li, Sue; Megazzini, Karen; Ortega, Orlando; Korelitz, James; de Sanchez, Sharon Sothern; Stoszek, Sonia K.; Yu, Qilu; Mofenson, Lynne M.; Siberry, George K.

In: Brazilian Journal of Infectious Diseases, Vol. 19, No. 3, 01.05.2015, p. 263-271.

Research output: Contribution to journalArticle

Duarte, HA, Harris, DR, Tassiopoulos, K, Leister, E, Negrini, SFBDM, Ferreira, FF, Cruz, MLS, Pinto, J, Allison, S, Hazra, R, Pinto, JA, Faleiro, FF, Maia, MM, Sperhacke, RD, Golin, N, Costamilan, SM, Pilotto, J, Moreira, LF, Gomes, I, Santos, BR, de Cassia Alves Lira, R, Peixoto, MF, Teles, E, Goldani, M, da Silva, CLO, Zanetello, MB, Kreitchmann, R, Scotta, MC, Coelho, DF, Mussi-Pinhata, MM, Cervi, MC, Isaac, ML, Sturzbecher, FT, Moura Negrini, BV, Oliveira, RHS, Chermont Sapia, MC, Joao, EC, Cruz, ML, Sidi, LC, Gouvêa, MI, Saavedra, MC, Bressan, C, Jundi, FCA, de Menezes Succi, RC, Machado, DM, Negra, MD, Queiroz, W, Lian, YC, Pavía-Ruz, N, Morales-Pérez, D, Ojeda-Diezbarroso, K, Alarcón Villaverde, JO, Díaz, MC, Bertucci, Y, Hance, LF, René Gonin, G, Robert Harris, D, Hennessey, R, Krauss, M, Li, S, Megazzini, K, Ortega, O, Korelitz, J, de Sanchez, SS, Stoszek, SK, Yu, Q, Mofenson, LM & Siberry, GK 2015, 'Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America', Brazilian Journal of Infectious Diseases, vol. 19, no. 3, pp. 263-271. https://doi.org/10.1016/j.bjid.2015.01.004
Duarte, Horacio A. ; Harris, Donald Robert ; Tassiopoulos, Katherine ; Leister, Erin ; Negrini, Silvia Fabiana Biason de Moura ; Ferreira, Flávia Faleiro ; Cruz, Maria Letícia Santos ; Pinto, Jorge ; Allison, Susannah ; Hazra, Rohan ; Pinto, Jorge A. ; Faleiro, Flávia F. ; Maia, Marcelle M. ; Sperhacke, Rosa Dea ; Golin, Nicole ; Costamilan, Sílvia Mariani ; Pilotto, Jose ; Moreira, Luis Felipe ; Gomes, Ivete ; Santos, Breno Riegel ; de Cassia Alves Lira, Rita ; Peixoto, Mario Ferreira ; Teles, Elizabete ; Goldani, Marcelo ; da Silva, Carmem Lúcia Oliveira ; Zanetello, Margery Bohrer ; Kreitchmann, Regis ; Scotta, Marcelo Comerlato ; Coelho, Debora Fernandes ; Mussi-Pinhata, Marisa M. ; Cervi, Maria Célia ; Isaac, Márcia L. ; Sturzbecher, Fernanda Tomé ; Moura Negrini, Bento V. ; Oliveira, Ricardo Hugo S ; Chermont Sapia, Maria C. ; Joao, Esau Custodio ; Cruz, Maria Leticia ; Sidi, Leon Claude ; Gouvêa, Maria Isabel ; Saavedra, Mariza Curto ; Bressan, Clarisse ; Jundi, Fernanda Cavalcanti A ; de Menezes Succi, Regina Celia ; Machado, Daisy Maria ; Negra, Marinella Della ; Queiroz, Wladimir ; Lian, Yu Ching ; Pavía-Ruz, Noris ; Morales-Pérez, Dulce ; Ojeda-Diezbarroso, Karla ; Alarcón Villaverde, Jorge O. ; Díaz, María Castillo ; Bertucci, Yolanda ; Hance, Laura Freimanis ; René Gonin, Gonin ; Robert Harris, D. ; Hennessey, Roslyn ; Krauss, Margot ; Li, Sue ; Megazzini, Karen ; Ortega, Orlando ; Korelitz, James ; de Sanchez, Sharon Sothern ; Stoszek, Sonia K. ; Yu, Qilu ; Mofenson, Lynne M. ; Siberry, George K. / Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America. In: Brazilian Journal of Infectious Diseases. 2015 ; Vol. 19, No. 3. pp. 263-271.
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