Relationship between the Val158met polymorphism of catechol O-methyl transferase and breast cancer

D. S. Yim, S. K. Park, K. Y. Yoo, K. S. Yoon, H. H. Chung, H. J. Kang, S. H. Ahn, D. Y. Noh, K. J. Choe, I. J. Jang, S. G. Shin, Paul Timothy Strickland, A. Hirvonen, D. Kang

Research output: Contribution to journalArticle

Abstract

A case-control study was performed to assess the potential influence of catechol O-methyl transferase (COMT) genotype on the risk of breast cancer in Korean women. One hundred and sixty-three histologically confirmed incident breast cancer cases and 163 age- and menopausal status-matched control individuals with no present or previous history of cancer were selected as study subjects. COMT genetic polymorphism was determined by gel electrophoresis after NIa III enzyme digestion of amplified DNA. Odds ratios and 95% confidence intervals were estimated by unconditional logistic regression after adjustment for known or suspected risk factors of breast cancer. Women with at least one COMT lower enzyme activity associated allele (COMT-L) were at elevated risk for breast cancer (OR = 1.7, 95% CI = 1.04-2.78) compared with those homozygous for high enzyme activity associated COMT-H alleles. Among women with low (≥ 23.1) body mass index the COMT-L allele containing genotypes posed a marginally significant increased risk of breast cancer compared to the COMT-HH genotype (OR = 1.8, 95% CI = 0.95-3.48). Women with at least one COMT-L allele who had experienced a full-term pregnancy when aged over 30 years or were nulliparous had 2.7-fold increased risk; however, this increase did not reach statistical significance (OR = 2.7, 95% CI = 0.64-11.35). Furthermore, never-drinking and never-smoking women with at least one COMT-L allele were at increased risk of breast cancer compared to those with COMT-HH genotype with ORs of 2.0 (95% CI = 1.23-3.38) and 1.7 (95% CI = 1.04-2.62), respectively. These results are consistent with studies showing that COMT genotype of lower enzyme activity might be related to increase in risk of breast cancer, and extend this finding to Korean women.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalPharmacogenetics
Volume11
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Guaiacol
Transferases
Breast Neoplasms
Alleles
Genotype
Enzymes
Genetic Polymorphisms
Drinking
Electrophoresis
Case-Control Studies
Digestion
Body Mass Index
Logistic Models
Smoking
Gels
Odds Ratio

Keywords

  • Breast cancer
  • COMT
  • Genetic polymorphism

ASJC Scopus subject areas

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Yim, D. S., Park, S. K., Yoo, K. Y., Yoon, K. S., Chung, H. H., Kang, H. J., ... Kang, D. (2001). Relationship between the Val158met polymorphism of catechol O-methyl transferase and breast cancer. Pharmacogenetics, 11(4), 279-286. https://doi.org/10.1097/00008571-200106000-00001

Relationship between the Val158met polymorphism of catechol O-methyl transferase and breast cancer. / Yim, D. S.; Park, S. K.; Yoo, K. Y.; Yoon, K. S.; Chung, H. H.; Kang, H. J.; Ahn, S. H.; Noh, D. Y.; Choe, K. J.; Jang, I. J.; Shin, S. G.; Strickland, Paul Timothy; Hirvonen, A.; Kang, D.

In: Pharmacogenetics, Vol. 11, No. 4, 2001, p. 279-286.

Research output: Contribution to journalArticle

Yim, DS, Park, SK, Yoo, KY, Yoon, KS, Chung, HH, Kang, HJ, Ahn, SH, Noh, DY, Choe, KJ, Jang, IJ, Shin, SG, Strickland, PT, Hirvonen, A & Kang, D 2001, 'Relationship between the Val158met polymorphism of catechol O-methyl transferase and breast cancer', Pharmacogenetics, vol. 11, no. 4, pp. 279-286. https://doi.org/10.1097/00008571-200106000-00001
Yim, D. S. ; Park, S. K. ; Yoo, K. Y. ; Yoon, K. S. ; Chung, H. H. ; Kang, H. J. ; Ahn, S. H. ; Noh, D. Y. ; Choe, K. J. ; Jang, I. J. ; Shin, S. G. ; Strickland, Paul Timothy ; Hirvonen, A. ; Kang, D. / Relationship between the Val158met polymorphism of catechol O-methyl transferase and breast cancer. In: Pharmacogenetics. 2001 ; Vol. 11, No. 4. pp. 279-286.
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abstract = "A case-control study was performed to assess the potential influence of catechol O-methyl transferase (COMT) genotype on the risk of breast cancer in Korean women. One hundred and sixty-three histologically confirmed incident breast cancer cases and 163 age- and menopausal status-matched control individuals with no present or previous history of cancer were selected as study subjects. COMT genetic polymorphism was determined by gel electrophoresis after NIa III enzyme digestion of amplified DNA. Odds ratios and 95{\%} confidence intervals were estimated by unconditional logistic regression after adjustment for known or suspected risk factors of breast cancer. Women with at least one COMT lower enzyme activity associated allele (COMT-L) were at elevated risk for breast cancer (OR = 1.7, 95{\%} CI = 1.04-2.78) compared with those homozygous for high enzyme activity associated COMT-H alleles. Among women with low (≥ 23.1) body mass index the COMT-L allele containing genotypes posed a marginally significant increased risk of breast cancer compared to the COMT-HH genotype (OR = 1.8, 95{\%} CI = 0.95-3.48). Women with at least one COMT-L allele who had experienced a full-term pregnancy when aged over 30 years or were nulliparous had 2.7-fold increased risk; however, this increase did not reach statistical significance (OR = 2.7, 95{\%} CI = 0.64-11.35). Furthermore, never-drinking and never-smoking women with at least one COMT-L allele were at increased risk of breast cancer compared to those with COMT-HH genotype with ORs of 2.0 (95{\%} CI = 1.23-3.38) and 1.7 (95{\%} CI = 1.04-2.62), respectively. These results are consistent with studies showing that COMT genotype of lower enzyme activity might be related to increase in risk of breast cancer, and extend this finding to Korean women.",
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