Relationship between the action of monoamine oxidase inhibitors on the noradrenaline uptake system and their antidepressant efficacy [16]

Edith D. Hendley; Solomon H. Snyder

doi:10.1038/2201330a0

Relationship between the action of monoamine oxidase inhibitors on the noradrenaline uptake system and their antidepressant efficacy [16]

Edith D. Hendley, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Letter › peer-review

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Abstract

MONOAMINE oxidase (MAO) inhibitors were the first clinically used antidepressant drugs. Several tricyclic compounds of iminodibenzyl or cycloheptadiene structure which do not inhibit MAO are also effective antidepressant drugs (refs. 1-3 and unpublished work of J. M. Davis, G. L. Klerman and J. J. Schildkraut), and seem to act by inhibiting the re-uptake inactivation of noradrenaline^4-7 and potentiating its effects in the brain.

Original language	English (US)
Pages (from-to)	1330-1331
Number of pages	2
Journal	Nature
Volume	220
Issue number	5174
DOIs	https://doi.org/10.1038/2201330a0
State	Published - 1968

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abstract = "MONOAMINE oxidase (MAO) inhibitors were the first clinically used antidepressant drugs. Several tricyclic compounds of iminodibenzyl or cycloheptadiene structure which do not inhibit MAO are also effective antidepressant drugs (refs. 1-3 and unpublished work of J. M. Davis, G. L. Klerman and J. J. Schildkraut), and seem to act by inhibiting the re-uptake inactivation of noradrenaline4-7 and potentiating its effects in the brain.",

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year = "1968",

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AU - Snyder, Solomon H.

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AB - MONOAMINE oxidase (MAO) inhibitors were the first clinically used antidepressant drugs. Several tricyclic compounds of iminodibenzyl or cycloheptadiene structure which do not inhibit MAO are also effective antidepressant drugs (refs. 1-3 and unpublished work of J. M. Davis, G. L. Klerman and J. J. Schildkraut), and seem to act by inhibiting the re-uptake inactivation of noradrenaline4-7 and potentiating its effects in the brain.

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Relationship between the action of monoamine oxidase inhibitors on the noradrenaline uptake system and their antidepressant efficacy [16]

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