Relationship between the action of monoamine oxidase inhibitors on the noradrenaline uptake system and their antidepressant efficacy [16]

Edith D. Hendley, Solomon H. Snyder

Research output: Contribution to journalLetter

Abstract

MONOAMINE oxidase (MAO) inhibitors were the first clinically used antidepressant drugs. Several tricyclic compounds of iminodibenzyl or cycloheptadiene structure which do not inhibit MAO are also effective antidepressant drugs (refs. 1-3 and unpublished work of J. M. Davis, G. L. Klerman and J. J. Schildkraut), and seem to act by inhibiting the re-uptake inactivation of noradrenaline4-7 and potentiating its effects in the brain.

Original languageEnglish (US)
Pages (from-to)1330-1331
Number of pages2
JournalNature
Volume220
Issue number5174
DOIs
StatePublished - Dec 1 1968

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ASJC Scopus subject areas

  • General

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