Relationship between specific serum IGE to Ascaris lumbricoides and onset of respiratory symptoms in Bangladesh immigrants

Gabriele Di Lorenzo, M. L. Pacor, P. Mansueto, M. Esposito-Pellitteri, N. Scichilone, V. Ditta, C. Lo Bianco, M. S. Leto-Barone, G. Di Fede, R. Corrocher, S. Mansueto, G. B. Rini

Research output: Contribution to journalArticle

Abstract

The role of helminths in asthma and/or rhinitis and in allergic sensitization is still unclear. We assessed the relationship between Ascaris-specific IgE, respiratory symptoms and allergic sensitization in Bangladesh immigrants. 246 individuals were examined from 1996 to 2001. Serum total IgE, Ascaris IgE, specific IgE to inhalant allergens, skin prick tests (SPT) and parasitological evaluation of the stool were performed. Total serum IgE were significantly higher in Ascaris-IgE positive (> 0.35 kU/L) individuals (806.5 [409.0-1436.0] kU/L vs. 207.0 [127.0-332.5] kU/L; P <0.0001) and in subjects with respiratory symptoms (413.0 [239.0-1096.0] kU/L vs. 259.5 [147.0-387.0] kU/L), (P <0.0001), but not in SPT positive subjects (413.0 [179.0-894.0] kU/L vs. 404.6 [305.0-1201.0] kU/L (P = 0.5). Ascaris-specific IgE were detected in 48 subjects with respiratory symptoms (40.0%) and in 46 subjects without respiratory symptoms (36.5%) (P = 0.5). The SPT positivity was similar between Ascaris-IgE seropositive (38.2%) and Ascaris-IgE seronegative (38.1%) subjects (P = 0.9). Total IgE and length of stay in Italy correlated with SPT positivity (OR 5.6 [CI 95% 1.5-19.8], P = 0.007, and OR 1.5 [CI 95% 1.3-1.7], P <0.0001), and with respiratory symptoms (OR 13.7 [CI 95% 3.0-62.4], P = 0.0007, and OR 2.4 [CI 95% 1.9-3.0], P <0.0001). Ascaris-IgE were negatively associated with SPT positivity (OR 0.3 [CI 95% 0.1-0.8], P = 0.02) and with respiratory symptoms (OR 0.1 [CI 95% 0.04-0.7], P = 0.01). Our findings favour the role of environmental factors in the development of respiratory symptoms in immigrants, irrespective of Ascaris-IgE.

Original languageEnglish (US)
Pages (from-to)629-638
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Volume19
Issue number3
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Ascaris lumbricoides
Bangladesh
Immunoglobulin E
Ascaris
Serum
Skin Tests
Helminths
Allergens
Italy
Length of Stay

Keywords

  • Allergen-specific IgE
  • Ascaris-specific IgE
  • Asthma rhinitis total serum IgE

ASJC Scopus subject areas

  • Pharmacology

Cite this

Di Lorenzo, G., Pacor, M. L., Mansueto, P., Esposito-Pellitteri, M., Scichilone, N., Ditta, V., ... Rini, G. B. (2006). Relationship between specific serum IGE to Ascaris lumbricoides and onset of respiratory symptoms in Bangladesh immigrants. International Journal of Immunopathology and Pharmacology, 19(3), 629-638.

Relationship between specific serum IGE to Ascaris lumbricoides and onset of respiratory symptoms in Bangladesh immigrants. / Di Lorenzo, Gabriele; Pacor, M. L.; Mansueto, P.; Esposito-Pellitteri, M.; Scichilone, N.; Ditta, V.; Lo Bianco, C.; Leto-Barone, M. S.; Di Fede, G.; Corrocher, R.; Mansueto, S.; Rini, G. B.

In: International Journal of Immunopathology and Pharmacology, Vol. 19, No. 3, 07.2006, p. 629-638.

Research output: Contribution to journalArticle

Di Lorenzo, G, Pacor, ML, Mansueto, P, Esposito-Pellitteri, M, Scichilone, N, Ditta, V, Lo Bianco, C, Leto-Barone, MS, Di Fede, G, Corrocher, R, Mansueto, S & Rini, GB 2006, 'Relationship between specific serum IGE to Ascaris lumbricoides and onset of respiratory symptoms in Bangladesh immigrants', International Journal of Immunopathology and Pharmacology, vol. 19, no. 3, pp. 629-638.
Di Lorenzo, Gabriele ; Pacor, M. L. ; Mansueto, P. ; Esposito-Pellitteri, M. ; Scichilone, N. ; Ditta, V. ; Lo Bianco, C. ; Leto-Barone, M. S. ; Di Fede, G. ; Corrocher, R. ; Mansueto, S. ; Rini, G. B. / Relationship between specific serum IGE to Ascaris lumbricoides and onset of respiratory symptoms in Bangladesh immigrants. In: International Journal of Immunopathology and Pharmacology. 2006 ; Vol. 19, No. 3. pp. 629-638.
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abstract = "The role of helminths in asthma and/or rhinitis and in allergic sensitization is still unclear. We assessed the relationship between Ascaris-specific IgE, respiratory symptoms and allergic sensitization in Bangladesh immigrants. 246 individuals were examined from 1996 to 2001. Serum total IgE, Ascaris IgE, specific IgE to inhalant allergens, skin prick tests (SPT) and parasitological evaluation of the stool were performed. Total serum IgE were significantly higher in Ascaris-IgE positive (> 0.35 kU/L) individuals (806.5 [409.0-1436.0] kU/L vs. 207.0 [127.0-332.5] kU/L; P <0.0001) and in subjects with respiratory symptoms (413.0 [239.0-1096.0] kU/L vs. 259.5 [147.0-387.0] kU/L), (P <0.0001), but not in SPT positive subjects (413.0 [179.0-894.0] kU/L vs. 404.6 [305.0-1201.0] kU/L (P = 0.5). Ascaris-specific IgE were detected in 48 subjects with respiratory symptoms (40.0{\%}) and in 46 subjects without respiratory symptoms (36.5{\%}) (P = 0.5). The SPT positivity was similar between Ascaris-IgE seropositive (38.2{\%}) and Ascaris-IgE seronegative (38.1{\%}) subjects (P = 0.9). Total IgE and length of stay in Italy correlated with SPT positivity (OR 5.6 [CI 95{\%} 1.5-19.8], P = 0.007, and OR 1.5 [CI 95{\%} 1.3-1.7], P <0.0001), and with respiratory symptoms (OR 13.7 [CI 95{\%} 3.0-62.4], P = 0.0007, and OR 2.4 [CI 95{\%} 1.9-3.0], P <0.0001). Ascaris-IgE were negatively associated with SPT positivity (OR 0.3 [CI 95{\%} 0.1-0.8], P = 0.02) and with respiratory symptoms (OR 0.1 [CI 95{\%} 0.04-0.7], P = 0.01). Our findings favour the role of environmental factors in the development of respiratory symptoms in immigrants, irrespective of Ascaris-IgE.",
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AU - Di Lorenzo, Gabriele

AU - Pacor, M. L.

AU - Mansueto, P.

AU - Esposito-Pellitteri, M.

AU - Scichilone, N.

AU - Ditta, V.

AU - Lo Bianco, C.

AU - Leto-Barone, M. S.

AU - Di Fede, G.

AU - Corrocher, R.

AU - Mansueto, S.

AU - Rini, G. B.

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N2 - The role of helminths in asthma and/or rhinitis and in allergic sensitization is still unclear. We assessed the relationship between Ascaris-specific IgE, respiratory symptoms and allergic sensitization in Bangladesh immigrants. 246 individuals were examined from 1996 to 2001. Serum total IgE, Ascaris IgE, specific IgE to inhalant allergens, skin prick tests (SPT) and parasitological evaluation of the stool were performed. Total serum IgE were significantly higher in Ascaris-IgE positive (> 0.35 kU/L) individuals (806.5 [409.0-1436.0] kU/L vs. 207.0 [127.0-332.5] kU/L; P <0.0001) and in subjects with respiratory symptoms (413.0 [239.0-1096.0] kU/L vs. 259.5 [147.0-387.0] kU/L), (P <0.0001), but not in SPT positive subjects (413.0 [179.0-894.0] kU/L vs. 404.6 [305.0-1201.0] kU/L (P = 0.5). Ascaris-specific IgE were detected in 48 subjects with respiratory symptoms (40.0%) and in 46 subjects without respiratory symptoms (36.5%) (P = 0.5). The SPT positivity was similar between Ascaris-IgE seropositive (38.2%) and Ascaris-IgE seronegative (38.1%) subjects (P = 0.9). Total IgE and length of stay in Italy correlated with SPT positivity (OR 5.6 [CI 95% 1.5-19.8], P = 0.007, and OR 1.5 [CI 95% 1.3-1.7], P <0.0001), and with respiratory symptoms (OR 13.7 [CI 95% 3.0-62.4], P = 0.0007, and OR 2.4 [CI 95% 1.9-3.0], P <0.0001). Ascaris-IgE were negatively associated with SPT positivity (OR 0.3 [CI 95% 0.1-0.8], P = 0.02) and with respiratory symptoms (OR 0.1 [CI 95% 0.04-0.7], P = 0.01). Our findings favour the role of environmental factors in the development of respiratory symptoms in immigrants, irrespective of Ascaris-IgE.

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