TY - JOUR
T1 - Relationship between sensorimotor peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the Health, Aging and Body Composition Study
AU - Lange-Maia, Brittney S.
AU - Newman, Anne B.
AU - Jakicic, John M.
AU - Cauley, Jane A.
AU - Boudreau, Robert M.
AU - Schwartz, Ann V.
AU - Simonsick, Eleanor M.
AU - Satterfield, Suzanne
AU - Vinik, Aaron I.
AU - Zivkovic, Sasa
AU - Harris, Tamara B.
AU - Strotmeyer, Elsa S.
N1 - Funding Information:
This work was supported by the National Institute on Aging (NIA) Contracts N01-AG-6-2101; N01-AG-6-2103; N01-AG-6-2106; NIA grant R01-AG028050 (to E.S.S.), and National Institute of Nursing Research grant R01-NR12459. This research was supported in part by the Intramural Research Program of the National Institute of Health, NIA, and the University of Pittsburgh Claude D. Pepper Older Americans Independence Center (P30-AG024827) Pilot Grant (to E.S.S.). Brittney S. Lange-Maia was funded by a National Institute on Aging Training Grant T32-AG000181 (to A.B.N.) during this work. Funding sources were not involved in the study design, data collection/analysis/interpretation, or in writing this manuscript. A preliminary version of this work was presented at an oral presentation at the 2015 Annual Meeting of the Gerontological Society of America in Orlando, FL.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Background Age-related peripheral nervous system (PNS) impairments are highly prevalent in older adults. Although sensorimotor and cardiovascular autonomic function have been shown to be related in persons with diabetes, the nature of the relationship in general community-dwelling older adult populations is unknown. Methods Health, Aging and Body Composition participants (n = 2399, age = 76.5 ± 2.9 years, 52% women, 38% black) underwent peripheral nerve testing at the 2000/01 clinic visit. Nerve conduction amplitude and velocity were measured at the peroneal motor nerve. Sensory nerve function was assessed with vibration detection threshold and monofilament (1.4-g/10-g) testing at the big toe. Symptoms of lower-extremity peripheral neuropathy were collected by self-report. Cardiovascular autonomic function indicators included postural hypotension, resting heart rate (HR), as well as HR response to and recovery from submaximal exercise testing (400 m walk). Multivariable modeling adjusted for demographic/lifestyle factors, medication use and comorbid conditions. Results In fully adjusted models, poor motor nerve conduction velocity (< 40 m/s) was associated with greater odds of postural hypotension, (OR = 1.6, 95% CI: 1.0–2.5), while poor motor amplitude (< 1 mV) was associated with 2.3 beats/min (p = 0.003) higher resting HR. No associations were observed between sensory nerve function or symptoms of peripheral neuropathy and indicators of cardiovascular autonomic function. Conclusions Motor nerve function and indicators of cardiovascular autonomic function remained significantly related even after considering many potentially shared risk factors. Future studies should investigate common underlying processes for developing multiple PNS impairments in older adults.
AB - Background Age-related peripheral nervous system (PNS) impairments are highly prevalent in older adults. Although sensorimotor and cardiovascular autonomic function have been shown to be related in persons with diabetes, the nature of the relationship in general community-dwelling older adult populations is unknown. Methods Health, Aging and Body Composition participants (n = 2399, age = 76.5 ± 2.9 years, 52% women, 38% black) underwent peripheral nerve testing at the 2000/01 clinic visit. Nerve conduction amplitude and velocity were measured at the peroneal motor nerve. Sensory nerve function was assessed with vibration detection threshold and monofilament (1.4-g/10-g) testing at the big toe. Symptoms of lower-extremity peripheral neuropathy were collected by self-report. Cardiovascular autonomic function indicators included postural hypotension, resting heart rate (HR), as well as HR response to and recovery from submaximal exercise testing (400 m walk). Multivariable modeling adjusted for demographic/lifestyle factors, medication use and comorbid conditions. Results In fully adjusted models, poor motor nerve conduction velocity (< 40 m/s) was associated with greater odds of postural hypotension, (OR = 1.6, 95% CI: 1.0–2.5), while poor motor amplitude (< 1 mV) was associated with 2.3 beats/min (p = 0.003) higher resting HR. No associations were observed between sensory nerve function or symptoms of peripheral neuropathy and indicators of cardiovascular autonomic function. Conclusions Motor nerve function and indicators of cardiovascular autonomic function remained significantly related even after considering many potentially shared risk factors. Future studies should investigate common underlying processes for developing multiple PNS impairments in older adults.
KW - Autonomic nervous system
KW - Older adults
KW - Peripheral nerves
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U2 - 10.1016/j.exger.2017.04.007
DO - 10.1016/j.exger.2017.04.007
M3 - Article
C2 - 28442382
AN - SCOPUS:85020733811
SN - 0531-5565
VL - 96
SP - 38
EP - 45
JO - Experimental Gerontology
JF - Experimental Gerontology
ER -