Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis

A. M. Diehl, James John Potter, J. Boitnott, M. A. Van Duyn, H. F. Herlong, Esteban Mezey

Research output: Contribution to journalArticle

Abstract

The relationship between pyridoxal phosphate deficiency and activities of serum and liver aminotransferases was studied in 12 patients with alcoholic hepatitis. Plasma pyridoxal phosphate and the activities of liver aminotransferases were initially decreased in the patients, as compared with mean values in controls with normal hepatic histology. Addition of pyridoxal phosphate to liver homogenates increased liver alanine aminotransferase, but not aspartate aminotransferase, in all patients with initially low plasma pyridoxal phosphate. After 1 mo of abstinence from alcohol, with intake of an adequate diet and pyridoxine supplementation, plasma pyridoxal phosphate increased in all patients with initially low values (p <0.02). Serum aspartate aminotransferase decreased, whereas serum alanine aminotransferase increased, resulting in a decrease in their ratio in serum (p <0.001). Liver alanine aminotransferase increased (p <0.005), whereas liver aspartate aminotransferase remained unchanged. These data suggest that pyridoxal 5'-phosphate depletion is partially responsible for the low serum alanine to aspartate aminotransferase ratio that is typical of patients with alcoholic hepatitis.

Original languageEnglish (US)
Pages (from-to)632-636
Number of pages5
JournalGastroenterology
Volume86
Issue number4
StatePublished - 1984

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Alcoholic Hepatitis
Pyridoxal Phosphate
Transaminases
Aspartate Aminotransferases
Liver
Alanine Transaminase
Serum
Alcohol Abstinence
Pyridoxine
Alanine
Histology
Diet

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis. / Diehl, A. M.; Potter, James John; Boitnott, J.; Van Duyn, M. A.; Herlong, H. F.; Mezey, Esteban.

In: Gastroenterology, Vol. 86, No. 4, 1984, p. 632-636.

Research output: Contribution to journalArticle

Diehl, A. M. ; Potter, James John ; Boitnott, J. ; Van Duyn, M. A. ; Herlong, H. F. ; Mezey, Esteban. / Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis. In: Gastroenterology. 1984 ; Vol. 86, No. 4. pp. 632-636.
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