TY - JOUR
T1 - Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme
AU - Li, Wen Bin
AU - Tang, Kai
AU - Zhang, Wei
AU - Yan, Wei
AU - You, Gang
AU - Li, Shao Wu
AU - Zhang, Long
AU - Huang, Yan Jie
AU - Jiang, Tao
PY - 2011/9
Y1 - 2011/9
N2 - Background Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. Magnetic resonance imaging (MRI) is routinely used in the diagnosis, characterization and clinical management of GBM. The diagnosis and treatment of GBM is largely guided by histopathology and immunohistochemistry. This study aimed to identify the relationship between magnetic resonance features and molecular pathology of GBM. Methods MRI images of 43 glioblastoma patients were collected. Four imaging features, degree of edema, contrast tumor enhanced/T2 ratio, multiple lesions and tumor across the midline, were selected to identify their relationship with P53, Ki-67 and O 6-methylguanine-DNA methltransferase (MGMT) expression in patients with GBM. The relationship between imaging features and molecular pathology was studied by chi-square test using the software SPSS 13.0. Results High expression of P53 was found correlated with low contrast tumor enhanced/T2 ratio, low expression of Ki-67 was correlated with multiple lesions and high expression of KI-67 may be related with tumor across the midline, low expression of MGMT was correlated with edema. Conclusion Some MRI features such as the degree of edema, contrast tumor enhanced/T2 ratio, multiple lesions and tumor acrossing the midline are correlated with P53, Ki-67 and MGMT of GBM.
AB - Background Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. Magnetic resonance imaging (MRI) is routinely used in the diagnosis, characterization and clinical management of GBM. The diagnosis and treatment of GBM is largely guided by histopathology and immunohistochemistry. This study aimed to identify the relationship between magnetic resonance features and molecular pathology of GBM. Methods MRI images of 43 glioblastoma patients were collected. Four imaging features, degree of edema, contrast tumor enhanced/T2 ratio, multiple lesions and tumor across the midline, were selected to identify their relationship with P53, Ki-67 and O 6-methylguanine-DNA methltransferase (MGMT) expression in patients with GBM. The relationship between imaging features and molecular pathology was studied by chi-square test using the software SPSS 13.0. Results High expression of P53 was found correlated with low contrast tumor enhanced/T2 ratio, low expression of Ki-67 was correlated with multiple lesions and high expression of KI-67 may be related with tumor across the midline, low expression of MGMT was correlated with edema. Conclusion Some MRI features such as the degree of edema, contrast tumor enhanced/T2 ratio, multiple lesions and tumor acrossing the midline are correlated with P53, Ki-67 and MGMT of GBM.
KW - Glioblastoma multiforme
KW - Magnetic resonance imaging
KW - Molecular pathology
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U2 - 10.3760/cma.j.issn.0366-6999.2011.17.005
DO - 10.3760/cma.j.issn.0366-6999.2011.17.005
M3 - Article
C2 - 22040408
AN - SCOPUS:80052544735
SN - 0366-6999
VL - 124
SP - 2589
EP - 2592
JO - Chinese medical journal
JF - Chinese medical journal
IS - 17
ER -