Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression*

ANKER JON HANSEN, BJØRN QUISTORFF, ALBERT GJEDDE

Research output: Contribution to journalArticlepeer-review

Abstract

Change of local cerebral blood flow in response to a single cortical spreading depression of Leäo was studied in the brain. During a spreading depression, potassium briefly accumulates in the brain extracellular space. The cortical blood flow was normal during the maximal rate of increase of the extracellular potassium concentration. The blood flow doubled during the subsequent period of normalization of potassium and remained high for one minute thereafter. Thus, potassium cannot be the immediate mediator of the blood flow increase.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalActa Physiologica Scandinavica
Volume109
Issue number1
DOIs
StatePublished - May 1980

Keywords

  • Spreading depression
  • brain extracellular potassium concentration
  • cerebral blood flow
  • metabolic autoregulation of blood flow

ASJC Scopus subject areas

  • Physiology

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