Relationship Between Inter-Arm Difference in Systolic Blood Pressure and Arterial Stiffness in Community-Dwelling Older Adults

Marco Canepa, Yuri Milaneschi, Pietro Ameri, Majd Alghatrif, Giovanna Leoncini, Paolo Spallarossa, Roberto Pontremoli, Claudio Brunelli, James B. Strait, Edward G. Lakatta, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

A significant inter-arm difference in systolic blood pressure (IADSBP) has recently been associated with worse cardiovascular outcomes. The authors hypothesized that part of this association is mediated by arterial stiffness, and examined the relationship between significant IADSBP and carotid-femoral pulse wave velocity (CF-PWV) in a sample from the Baltimore Longitudinal Study of Aging. Of 1045 participants, 50 (4.8%) had an IADSBP ≥10 mm Hg at baseline, and 629 had completed data from ≥2 visits (for a total of 1704 visits during 8 years). CF-PWV was significantly higher in patients with an IADSBP ≥10 mm Hg (7.3±1.9 vs 8.2±2, P=.002). Compared with others, patients with IADSBP ≥10 mm Hg also had higher body mass index, waist circumference, and triglycerides; higher prevalence of diabetes; and lower high-density lipoprotein (HDL) cholesterol (P<.001 for all). A significant association with IADSBP ≥10 mm Hg was observed for CF-PWV in both cross-sectional (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.06-1.87; P=.01) and longitudinal (OR, 1.15; 95% CI, 1.03-1.29; P=.01) multivariate analyses. Female sex, Caucasian race, high body mass index (plus diabetes and low HDL cholesterol only cross-sectionally) were other independent correlates of IADSBP ≥10 mm Hg. Significant IADSBP is associated with increased arterial stiffness in community-dwelling older adults.

Original languageEnglish (US)
Pages (from-to)880-887
Number of pages8
JournalJournal of Clinical Hypertension
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2013

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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    Canepa, M., Milaneschi, Y., Ameri, P., Alghatrif, M., Leoncini, G., Spallarossa, P., Pontremoli, R., Brunelli, C., Strait, J. B., Lakatta, E. G., & Ferrucci, L. (2013). Relationship Between Inter-Arm Difference in Systolic Blood Pressure and Arterial Stiffness in Community-Dwelling Older Adults. Journal of Clinical Hypertension, 15(12), 880-887. https://doi.org/10.1111/jch.12178