TY - JOUR
T1 - Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program
AU - the Childhood Asthma Management Program Research Group
AU - Weiss, Scott T.
AU - Van Natta, Mark L.
AU - Zeiger, Robert S.
PY - 2000
Y1 - 2000
N2 - The relationship between increased airway responsiveness and asthma severity in children is unclear. The Childhood Asthma Management Program (CAMP) with 1,041 children with mild to moderate asthma offers an opportunity to relate the concentration of methacholine that causes a 20% fall in FEV1 (PC20) to level of lung function, occurrence of respiratory symptoms, duration of disease, and assessment of severity by clinical staff. Decreasing PC20 was found to be associated with lower levels of lung function (prebronchodilator percent predicted FEV1: r = 0.29, β = 3.5, p < 0.001), the occurrence of chronic asthma symptoms, persistent wheezing (odds ratio [OR] = 1.66, p < 0.001), subjective clinical staff assessment of asthma severity (p < 0.001), and longer duration of asthma (r = -0.11, β = -0.20, p < 0.002). These data provide evidence that the degree of airway responsiveness is linked to disease severity in children with mild to moderate asthma.
AB - The relationship between increased airway responsiveness and asthma severity in children is unclear. The Childhood Asthma Management Program (CAMP) with 1,041 children with mild to moderate asthma offers an opportunity to relate the concentration of methacholine that causes a 20% fall in FEV1 (PC20) to level of lung function, occurrence of respiratory symptoms, duration of disease, and assessment of severity by clinical staff. Decreasing PC20 was found to be associated with lower levels of lung function (prebronchodilator percent predicted FEV1: r = 0.29, β = 3.5, p < 0.001), the occurrence of chronic asthma symptoms, persistent wheezing (odds ratio [OR] = 1.66, p < 0.001), subjective clinical staff assessment of asthma severity (p < 0.001), and longer duration of asthma (r = -0.11, β = -0.20, p < 0.002). These data provide evidence that the degree of airway responsiveness is linked to disease severity in children with mild to moderate asthma.
UR - http://www.scopus.com/inward/record.url?scp=0033940777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033940777&partnerID=8YFLogxK
U2 - 10.1164/ajrccm.162.1.9811005
DO - 10.1164/ajrccm.162.1.9811005
M3 - Article
C2 - 10903219
AN - SCOPUS:0033940777
SN - 1073-449X
VL - 162
SP - 50
EP - 56
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 1
ER -