Relationship between higher estradiol levels and 9-year mortality in older women

Marcello Maggio, Gian Paolo Ceda, Fulvio Lauretani, Stefania Bandinelli, Carmelinda Ruggiero, Jack M. Guralnik, E. Jeffrey Metter, Shari M. Ling, Giuseppe Paolisso, Giorgio Valenti, Anne R. Cappola, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN: Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING: Community. PARTICIPANTS: A representative sample of 509 women aged 65 and older with measures of total E2. MEASUREMENTS: Serum total E2 was measured at the University of Parma using ultrasensitive radioimmunoassay (RIA). RESULTS: Women who died (n=135) during 9 years of follow up were older; had higher total E2 levels; and were more likely to have evidence of stroke, hypertension, diabetes mellitus, and congestive heart failure at baseline than survivors. Higher E2 levels were associated with a greater likelihood of death (hazard ratio (HR)=1.03, 95% confidence interval (CI)=1.01-1.06), and the relationship was independent of age, waist:hip ratio, C-reactive protein, education, cognitive function, physical activity, caloric intake, smoking, and chronic disease (HR=1.08 pg/mL, 95% CI=1.03-1.13, P=.003). The excessive risk of death associated with higher total E2 was not attenuated after adjustment for total testosterone (HR=1.12, 95% CI=1.02-1.18, P

Original languageEnglish (US)
Pages (from-to)1810-1815
Number of pages6
JournalJournal of the American Geriatrics Society
Volume57
Issue number10
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Estradiol
Confidence Intervals
Mortality
Waist-Hip Ratio
Hormone Replacement Therapy
Energy Intake
C-Reactive Protein
Cognition
Italy
Radioimmunoassay
Survivors
Testosterone
Diabetes Mellitus
Chronic Disease
Heart Failure
Smoking
Stroke
Exercise
Hypertension
Education

Keywords

  • Estradiol
  • Mortality
  • Older postmenopausal women

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Maggio, M., Ceda, G. P., Lauretani, F., Bandinelli, S., Ruggiero, C., Guralnik, J. M., ... Ferrucci, L. (2009). Relationship between higher estradiol levels and 9-year mortality in older women. Journal of the American Geriatrics Society, 57(10), 1810-1815. https://doi.org/10.1111/j.1532-5415.2009.02464.x

Relationship between higher estradiol levels and 9-year mortality in older women. / Maggio, Marcello; Ceda, Gian Paolo; Lauretani, Fulvio; Bandinelli, Stefania; Ruggiero, Carmelinda; Guralnik, Jack M.; Jeffrey Metter, E.; Ling, Shari M.; Paolisso, Giuseppe; Valenti, Giorgio; Cappola, Anne R.; Ferrucci, Luigi.

In: Journal of the American Geriatrics Society, Vol. 57, No. 10, 2009, p. 1810-1815.

Research output: Contribution to journalArticle

Maggio, M, Ceda, GP, Lauretani, F, Bandinelli, S, Ruggiero, C, Guralnik, JM, Jeffrey Metter, E, Ling, SM, Paolisso, G, Valenti, G, Cappola, AR & Ferrucci, L 2009, 'Relationship between higher estradiol levels and 9-year mortality in older women', Journal of the American Geriatrics Society, vol. 57, no. 10, pp. 1810-1815. https://doi.org/10.1111/j.1532-5415.2009.02464.x
Maggio, Marcello ; Ceda, Gian Paolo ; Lauretani, Fulvio ; Bandinelli, Stefania ; Ruggiero, Carmelinda ; Guralnik, Jack M. ; Jeffrey Metter, E. ; Ling, Shari M. ; Paolisso, Giuseppe ; Valenti, Giorgio ; Cappola, Anne R. ; Ferrucci, Luigi. / Relationship between higher estradiol levels and 9-year mortality in older women. In: Journal of the American Geriatrics Society. 2009 ; Vol. 57, No. 10. pp. 1810-1815.
@article{7dcd6788f4744d6da7ed97bb245bd98b,
title = "Relationship between higher estradiol levels and 9-year mortality in older women",
abstract = "OBJECTIVES: To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN: Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING: Community. PARTICIPANTS: A representative sample of 509 women aged 65 and older with measures of total E2. MEASUREMENTS: Serum total E2 was measured at the University of Parma using ultrasensitive radioimmunoassay (RIA). RESULTS: Women who died (n=135) during 9 years of follow up were older; had higher total E2 levels; and were more likely to have evidence of stroke, hypertension, diabetes mellitus, and congestive heart failure at baseline than survivors. Higher E2 levels were associated with a greater likelihood of death (hazard ratio (HR)=1.03, 95{\%} confidence interval (CI)=1.01-1.06), and the relationship was independent of age, waist:hip ratio, C-reactive protein, education, cognitive function, physical activity, caloric intake, smoking, and chronic disease (HR=1.08 pg/mL, 95{\%} CI=1.03-1.13, P=.003). The excessive risk of death associated with higher total E2 was not attenuated after adjustment for total testosterone (HR=1.12, 95{\%} CI=1.02-1.18, P",
keywords = "Estradiol, Mortality, Older postmenopausal women",
author = "Marcello Maggio and Ceda, {Gian Paolo} and Fulvio Lauretani and Stefania Bandinelli and Carmelinda Ruggiero and Guralnik, {Jack M.} and {Jeffrey Metter}, E. and Ling, {Shari M.} and Giuseppe Paolisso and Giorgio Valenti and Cappola, {Anne R.} and Luigi Ferrucci",
year = "2009",
doi = "10.1111/j.1532-5415.2009.02464.x",
language = "English (US)",
volume = "57",
pages = "1810--1815",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Relationship between higher estradiol levels and 9-year mortality in older women

AU - Maggio, Marcello

AU - Ceda, Gian Paolo

AU - Lauretani, Fulvio

AU - Bandinelli, Stefania

AU - Ruggiero, Carmelinda

AU - Guralnik, Jack M.

AU - Jeffrey Metter, E.

AU - Ling, Shari M.

AU - Paolisso, Giuseppe

AU - Valenti, Giorgio

AU - Cappola, Anne R.

AU - Ferrucci, Luigi

PY - 2009

Y1 - 2009

N2 - OBJECTIVES: To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN: Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING: Community. PARTICIPANTS: A representative sample of 509 women aged 65 and older with measures of total E2. MEASUREMENTS: Serum total E2 was measured at the University of Parma using ultrasensitive radioimmunoassay (RIA). RESULTS: Women who died (n=135) during 9 years of follow up were older; had higher total E2 levels; and were more likely to have evidence of stroke, hypertension, diabetes mellitus, and congestive heart failure at baseline than survivors. Higher E2 levels were associated with a greater likelihood of death (hazard ratio (HR)=1.03, 95% confidence interval (CI)=1.01-1.06), and the relationship was independent of age, waist:hip ratio, C-reactive protein, education, cognitive function, physical activity, caloric intake, smoking, and chronic disease (HR=1.08 pg/mL, 95% CI=1.03-1.13, P=.003). The excessive risk of death associated with higher total E2 was not attenuated after adjustment for total testosterone (HR=1.12, 95% CI=1.02-1.18, P

AB - OBJECTIVES: To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN: Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING: Community. PARTICIPANTS: A representative sample of 509 women aged 65 and older with measures of total E2. MEASUREMENTS: Serum total E2 was measured at the University of Parma using ultrasensitive radioimmunoassay (RIA). RESULTS: Women who died (n=135) during 9 years of follow up were older; had higher total E2 levels; and were more likely to have evidence of stroke, hypertension, diabetes mellitus, and congestive heart failure at baseline than survivors. Higher E2 levels were associated with a greater likelihood of death (hazard ratio (HR)=1.03, 95% confidence interval (CI)=1.01-1.06), and the relationship was independent of age, waist:hip ratio, C-reactive protein, education, cognitive function, physical activity, caloric intake, smoking, and chronic disease (HR=1.08 pg/mL, 95% CI=1.03-1.13, P=.003). The excessive risk of death associated with higher total E2 was not attenuated after adjustment for total testosterone (HR=1.12, 95% CI=1.02-1.18, P

KW - Estradiol

KW - Mortality

KW - Older postmenopausal women

UR - http://www.scopus.com/inward/record.url?scp=70350406124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350406124&partnerID=8YFLogxK

U2 - 10.1111/j.1532-5415.2009.02464.x

DO - 10.1111/j.1532-5415.2009.02464.x

M3 - Article

C2 - 19737330

AN - SCOPUS:70350406124

VL - 57

SP - 1810

EP - 1815

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 10

ER -