Abstract
OBJECTIVES: To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN: Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING: Community. PARTICIPANTS: A representative sample of 509 women aged 65 and older with measures of total E2. MEASUREMENTS: Serum total E2 was measured at the University of Parma using ultrasensitive radioimmunoassay (RIA). RESULTS: Women who died (n=135) during 9 years of follow up were older; had higher total E2 levels; and were more likely to have evidence of stroke, hypertension, diabetes mellitus, and congestive heart failure at baseline than survivors. Higher E2 levels were associated with a greater likelihood of death (hazard ratio (HR)=1.03, 95% confidence interval (CI)=1.01-1.06), and the relationship was independent of age, waist:hip ratio, C-reactive protein, education, cognitive function, physical activity, caloric intake, smoking, and chronic disease (HR=1.08 pg/mL, 95% CI=1.03-1.13, P=.003). The excessive risk of death associated with higher total E2 was not attenuated after adjustment for total testosterone (HR=1.12, 95% CI=1.02-1.18, P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1810-1815 |
| Number of pages | 6 |
| Journal | Journal of the American Geriatrics Society |
| Volume | 57 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
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Keywords
- Estradiol
- Mortality
- Older postmenopausal women
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Relationship between higher estradiol levels and 9-year mortality in older women. / Maggio, Marcello; Ceda, Gian Paolo; Lauretani, Fulvio; Bandinelli, Stefania; Ruggiero, Carmelinda; Guralnik, Jack M.; Jeffrey Metter, E.; Ling, Shari M.; Paolisso, Giuseppe; Valenti, Giorgio; Cappola, Anne R.; Ferrucci, Luigi.
In: Journal of the American Geriatrics Society, Vol. 57, No. 10, 2009, p. 1810-1815.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between higher estradiol levels and 9-year mortality in older women
AU - Maggio, Marcello
AU - Ceda, Gian Paolo
AU - Lauretani, Fulvio
AU - Bandinelli, Stefania
AU - Ruggiero, Carmelinda
AU - Guralnik, Jack M.
AU - Jeffrey Metter, E.
AU - Ling, Shari M.
AU - Paolisso, Giuseppe
AU - Valenti, Giorgio
AU - Cappola, Anne R.
AU - Ferrucci, Luigi
PY - 2009
Y1 - 2009
N2 - OBJECTIVES: To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN: Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING: Community. PARTICIPANTS: A representative sample of 509 women aged 65 and older with measures of total E2. MEASUREMENTS: Serum total E2 was measured at the University of Parma using ultrasensitive radioimmunoassay (RIA). RESULTS: Women who died (n=135) during 9 years of follow up were older; had higher total E2 levels; and were more likely to have evidence of stroke, hypertension, diabetes mellitus, and congestive heart failure at baseline than survivors. Higher E2 levels were associated with a greater likelihood of death (hazard ratio (HR)=1.03, 95% confidence interval (CI)=1.01-1.06), and the relationship was independent of age, waist:hip ratio, C-reactive protein, education, cognitive function, physical activity, caloric intake, smoking, and chronic disease (HR=1.08 pg/mL, 95% CI=1.03-1.13, P=.003). The excessive risk of death associated with higher total E2 was not attenuated after adjustment for total testosterone (HR=1.12, 95% CI=1.02-1.18, P
AB - OBJECTIVES: To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT). DESIGN: Population-based study of persons living in the Chianti geographic area (Tuscany, Italy). SETTING: Community. PARTICIPANTS: A representative sample of 509 women aged 65 and older with measures of total E2. MEASUREMENTS: Serum total E2 was measured at the University of Parma using ultrasensitive radioimmunoassay (RIA). RESULTS: Women who died (n=135) during 9 years of follow up were older; had higher total E2 levels; and were more likely to have evidence of stroke, hypertension, diabetes mellitus, and congestive heart failure at baseline than survivors. Higher E2 levels were associated with a greater likelihood of death (hazard ratio (HR)=1.03, 95% confidence interval (CI)=1.01-1.06), and the relationship was independent of age, waist:hip ratio, C-reactive protein, education, cognitive function, physical activity, caloric intake, smoking, and chronic disease (HR=1.08 pg/mL, 95% CI=1.03-1.13, P=.003). The excessive risk of death associated with higher total E2 was not attenuated after adjustment for total testosterone (HR=1.12, 95% CI=1.02-1.18, P
KW - Estradiol
KW - Mortality
KW - Older postmenopausal women
UR - http://www.scopus.com/inward/record.url?scp=70350406124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350406124&partnerID=8YFLogxK
U2 - 10.1111/j.1532-5415.2009.02464.x
DO - 10.1111/j.1532-5415.2009.02464.x
M3 - Article
C2 - 19737330
AN - SCOPUS:70350406124
VL - 57
SP - 1810
EP - 1815
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
IS - 10
ER -