Relationship between gestational fasting plasma glucose and neonatal birth weight, prenatal blood pressure and dystocia in pregnant Chinese women

Min Zhu, Jing Cai, Shujuan Liu, Mingwei Huang, Yao Chen, Xiaolan Lai, Yuyu Chen, Zhongwen Zhao, Fangzhen Wu, Dongmei Wu, Haiyan Miu, Shenghan Lai, Gang Chen

Research output: Contribution to journalArticle

Abstract

Background: Little is known about the optimal cut-off point of fasting plasma glucose for the diagnosis of gestational diabetes mellitus for pregnant Chinese women. This study investigates the relationship between gestational fasting plasma glucose and several variables: neonatal birth weight, prenatal blood pressure and dystocia rate of pregnant women. In this study, we hoped to provide a useful tool to screen gestational diabetes mellitus in pregnant Chinese women. Methods: For 1058 pregnant women enrolled in our hospital at pregnancy weeks 22-30, fasting plasma glucose, neonatal birth weight and prenatal blood pressure, as well as dystocia conditions, were examined. We analysed the correlations between the following: gestational fasting plasma glucose and neonatal birth weight; prenatal blood pressure and gestational fasting plasma glucose as well as dystocia rate and gestational fasting plasma glucose group. Results: A modest correlation was observed between gestational fasting plasma glucose and neonatal birth weight (r=0.093, p=0.003). The macrosomia rate was smallest when the gestational fasting plasma glucose was in the range 3.51-5.5mmol/L. Prenatal blood pressure increased linearly with increasing gestational fasting plasma glucose (p=0.000). There was a significant difference between the dystocia rates in different fasting plasma glucose groups (chi-squared=13.015, p=0.043). The results showed that the dystocia rate significantly increased when gestational fasting plasma glucose was >4.9mmol/L; p=0.03, OR=2.156 (95% CI, 1.077-4.318). Conclusion: We suggest that the optimal range of gestational fasting plasma glucose for pregnant Chinese women is in the range 3.5-4.9mmol/L.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalDiabetes/Metabolism Research and Reviews
Volume30
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Dystocia
Birth Weight
Pregnant Women
Fasting
Blood Pressure
Glucose
Gestational Diabetes

Keywords

  • Chinese
  • Dystocia
  • Gestational fasting plasma glucose
  • Neonatal birth weight
  • Pregnant women
  • Prenatal blood pressure

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Medicine(all)

Cite this

Relationship between gestational fasting plasma glucose and neonatal birth weight, prenatal blood pressure and dystocia in pregnant Chinese women. / Zhu, Min; Cai, Jing; Liu, Shujuan; Huang, Mingwei; Chen, Yao; Lai, Xiaolan; Chen, Yuyu; Zhao, Zhongwen; Wu, Fangzhen; Wu, Dongmei; Miu, Haiyan; Lai, Shenghan; Chen, Gang.

In: Diabetes/Metabolism Research and Reviews, Vol. 30, No. 6, 2014, p. 489-496.

Research output: Contribution to journalArticle

Zhu, Min ; Cai, Jing ; Liu, Shujuan ; Huang, Mingwei ; Chen, Yao ; Lai, Xiaolan ; Chen, Yuyu ; Zhao, Zhongwen ; Wu, Fangzhen ; Wu, Dongmei ; Miu, Haiyan ; Lai, Shenghan ; Chen, Gang. / Relationship between gestational fasting plasma glucose and neonatal birth weight, prenatal blood pressure and dystocia in pregnant Chinese women. In: Diabetes/Metabolism Research and Reviews. 2014 ; Vol. 30, No. 6. pp. 489-496.
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abstract = "Background: Little is known about the optimal cut-off point of fasting plasma glucose for the diagnosis of gestational diabetes mellitus for pregnant Chinese women. This study investigates the relationship between gestational fasting plasma glucose and several variables: neonatal birth weight, prenatal blood pressure and dystocia rate of pregnant women. In this study, we hoped to provide a useful tool to screen gestational diabetes mellitus in pregnant Chinese women. Methods: For 1058 pregnant women enrolled in our hospital at pregnancy weeks 22-30, fasting plasma glucose, neonatal birth weight and prenatal blood pressure, as well as dystocia conditions, were examined. We analysed the correlations between the following: gestational fasting plasma glucose and neonatal birth weight; prenatal blood pressure and gestational fasting plasma glucose as well as dystocia rate and gestational fasting plasma glucose group. Results: A modest correlation was observed between gestational fasting plasma glucose and neonatal birth weight (r=0.093, p=0.003). The macrosomia rate was smallest when the gestational fasting plasma glucose was in the range 3.51-5.5mmol/L. Prenatal blood pressure increased linearly with increasing gestational fasting plasma glucose (p=0.000). There was a significant difference between the dystocia rates in different fasting plasma glucose groups (chi-squared=13.015, p=0.043). The results showed that the dystocia rate significantly increased when gestational fasting plasma glucose was >4.9mmol/L; p=0.03, OR=2.156 (95{\%} CI, 1.077-4.318). Conclusion: We suggest that the optimal range of gestational fasting plasma glucose for pregnant Chinese women is in the range 3.5-4.9mmol/L.",
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T1 - Relationship between gestational fasting plasma glucose and neonatal birth weight, prenatal blood pressure and dystocia in pregnant Chinese women

AU - Zhu, Min

AU - Cai, Jing

AU - Liu, Shujuan

AU - Huang, Mingwei

AU - Chen, Yao

AU - Lai, Xiaolan

AU - Chen, Yuyu

AU - Zhao, Zhongwen

AU - Wu, Fangzhen

AU - Wu, Dongmei

AU - Miu, Haiyan

AU - Lai, Shenghan

AU - Chen, Gang

PY - 2014

Y1 - 2014

N2 - Background: Little is known about the optimal cut-off point of fasting plasma glucose for the diagnosis of gestational diabetes mellitus for pregnant Chinese women. This study investigates the relationship between gestational fasting plasma glucose and several variables: neonatal birth weight, prenatal blood pressure and dystocia rate of pregnant women. In this study, we hoped to provide a useful tool to screen gestational diabetes mellitus in pregnant Chinese women. Methods: For 1058 pregnant women enrolled in our hospital at pregnancy weeks 22-30, fasting plasma glucose, neonatal birth weight and prenatal blood pressure, as well as dystocia conditions, were examined. We analysed the correlations between the following: gestational fasting plasma glucose and neonatal birth weight; prenatal blood pressure and gestational fasting plasma glucose as well as dystocia rate and gestational fasting plasma glucose group. Results: A modest correlation was observed between gestational fasting plasma glucose and neonatal birth weight (r=0.093, p=0.003). The macrosomia rate was smallest when the gestational fasting plasma glucose was in the range 3.51-5.5mmol/L. Prenatal blood pressure increased linearly with increasing gestational fasting plasma glucose (p=0.000). There was a significant difference between the dystocia rates in different fasting plasma glucose groups (chi-squared=13.015, p=0.043). The results showed that the dystocia rate significantly increased when gestational fasting plasma glucose was >4.9mmol/L; p=0.03, OR=2.156 (95% CI, 1.077-4.318). Conclusion: We suggest that the optimal range of gestational fasting plasma glucose for pregnant Chinese women is in the range 3.5-4.9mmol/L.

AB - Background: Little is known about the optimal cut-off point of fasting plasma glucose for the diagnosis of gestational diabetes mellitus for pregnant Chinese women. This study investigates the relationship between gestational fasting plasma glucose and several variables: neonatal birth weight, prenatal blood pressure and dystocia rate of pregnant women. In this study, we hoped to provide a useful tool to screen gestational diabetes mellitus in pregnant Chinese women. Methods: For 1058 pregnant women enrolled in our hospital at pregnancy weeks 22-30, fasting plasma glucose, neonatal birth weight and prenatal blood pressure, as well as dystocia conditions, were examined. We analysed the correlations between the following: gestational fasting plasma glucose and neonatal birth weight; prenatal blood pressure and gestational fasting plasma glucose as well as dystocia rate and gestational fasting plasma glucose group. Results: A modest correlation was observed between gestational fasting plasma glucose and neonatal birth weight (r=0.093, p=0.003). The macrosomia rate was smallest when the gestational fasting plasma glucose was in the range 3.51-5.5mmol/L. Prenatal blood pressure increased linearly with increasing gestational fasting plasma glucose (p=0.000). There was a significant difference between the dystocia rates in different fasting plasma glucose groups (chi-squared=13.015, p=0.043). The results showed that the dystocia rate significantly increased when gestational fasting plasma glucose was >4.9mmol/L; p=0.03, OR=2.156 (95% CI, 1.077-4.318). Conclusion: We suggest that the optimal range of gestational fasting plasma glucose for pregnant Chinese women is in the range 3.5-4.9mmol/L.

KW - Chinese

KW - Dystocia

KW - Gestational fasting plasma glucose

KW - Neonatal birth weight

KW - Pregnant women

KW - Prenatal blood pressure

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