Relationship between genetic control of T-cell mitogen response and thyroiditis susceptibility in inbred rats

Hyun S. Lillehoj; Noel R. Rose

doi:10.1016/0008-8749(81)90309-9

Relationship between genetic control of T-cell mitogen response and thyroiditis susceptibility in inbred rats

Hyun S. Lillehoj, Noel R. Rose

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Relationship between susceptibility to experimental autoimmune thyroiditis (EAT) and mitogen response was investigated in CDF and SHR rats. Highly disease-susceptible CDF rats demonstrated significantly lower phytohemagglutinin responses compared to poorly susceptible SHR rats. Cross-breeding studies involving CDF and SHR rats showed that the IrRaTg gene does not segregate with the gene controlling mitogen response. Susceptibility to EAT is under polygenic control while PHA response is controlled by a major autosomal gene not linked to RT1.

Original language	English (US)
Pages (from-to)	156-163
Number of pages	8
Journal	Cellular Immunology
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(81)90309-9
State	Published - Jul 15 1981
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(81)90309-9

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title = "Relationship between genetic control of T-cell mitogen response and thyroiditis susceptibility in inbred rats",

abstract = "Relationship between susceptibility to experimental autoimmune thyroiditis (EAT) and mitogen response was investigated in CDF and SHR rats. Highly disease-susceptible CDF rats demonstrated significantly lower phytohemagglutinin responses compared to poorly susceptible SHR rats. Cross-breeding studies involving CDF and SHR rats showed that the IrRaTg gene does not segregate with the gene controlling mitogen response. Susceptibility to EAT is under polygenic control while PHA response is controlled by a major autosomal gene not linked to RT1.",

author = "Lillehoj, {Hyun S.} and Rose, {Noel R.}",

note = "Funding Information: {\textquoteright} This work was supported by NIH Grant AM 20023. * Recipient of National Research Service Award CA 09304-02 from the United States Public Health Service. r To whom requests for reprints should be sent at: Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 E. Canfield Ave. Detroit, Mich. 48201. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1981",

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doi = "10.1016/0008-8749(81)90309-9",

language = "English (US)",

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T1 - Relationship between genetic control of T-cell mitogen response and thyroiditis susceptibility in inbred rats

AU - Lillehoj, Hyun S.

AU - Rose, Noel R.

N1 - Funding Information: ’ This work was supported by NIH Grant AM 20023. * Recipient of National Research Service Award CA 09304-02 from the United States Public Health Service. r To whom requests for reprints should be sent at: Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 E. Canfield Ave. Detroit, Mich. 48201. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1981/7/15

Y1 - 1981/7/15

N2 - Relationship between susceptibility to experimental autoimmune thyroiditis (EAT) and mitogen response was investigated in CDF and SHR rats. Highly disease-susceptible CDF rats demonstrated significantly lower phytohemagglutinin responses compared to poorly susceptible SHR rats. Cross-breeding studies involving CDF and SHR rats showed that the IrRaTg gene does not segregate with the gene controlling mitogen response. Susceptibility to EAT is under polygenic control while PHA response is controlled by a major autosomal gene not linked to RT1.

AB - Relationship between susceptibility to experimental autoimmune thyroiditis (EAT) and mitogen response was investigated in CDF and SHR rats. Highly disease-susceptible CDF rats demonstrated significantly lower phytohemagglutinin responses compared to poorly susceptible SHR rats. Cross-breeding studies involving CDF and SHR rats showed that the IrRaTg gene does not segregate with the gene controlling mitogen response. Susceptibility to EAT is under polygenic control while PHA response is controlled by a major autosomal gene not linked to RT1.

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Relationship between genetic control of T-cell mitogen response and thyroiditis susceptibility in inbred rats

Abstract

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