Relationship between susceptibility to experimental autoimmune thyroiditis (EAT) and mitogen response was investigated in CDF and SHR rats. Highly disease-susceptible CDF rats demonstrated significantly lower phytohemagglutinin responses compared to poorly susceptible SHR rats. Cross-breeding studies involving CDF and SHR rats showed that the IrRaTg gene does not segregate with the gene controlling mitogen response. Susceptibility to EAT is under polygenic control while PHA response is controlled by a major autosomal gene not linked to RT1.
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