Relationship between genetic control of T-cell mitogen response and thyroiditis susceptibility in inbred rats

Hyun S. Lillehoj, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Relationship between susceptibility to experimental autoimmune thyroiditis (EAT) and mitogen response was investigated in CDF and SHR rats. Highly disease-susceptible CDF rats demonstrated significantly lower phytohemagglutinin responses compared to poorly susceptible SHR rats. Cross-breeding studies involving CDF and SHR rats showed that the IrRaTg gene does not segregate with the gene controlling mitogen response. Susceptibility to EAT is under polygenic control while PHA response is controlled by a major autosomal gene not linked to RT1.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalCellular Immunology
Volume62
Issue number1
DOIs
StatePublished - Jul 15 1981

ASJC Scopus subject areas

  • Immunology

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