Relationship between diffusion capacity and small airway abnormality in COPDGene

Rachel N. Criner; Charles R. Hatt; Craig J. Galbán; Ella A. Kazerooni; David A. Lynch; Meredith C. McCormack; Richard Casaburi; Neil R. MacIntyre; Barry J. Make; Fernando J. Martinez; Wassim W. Labaki; Jeffrey L. Curtis; Mei Lan K. Han

doi:10.1186/s12931-019-1237-1

Relationship between diffusion capacity and small airway abnormality in COPDGene

Rachel N. Criner, Charles R. Hatt, Craig J. Galbán, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, Neil R. MacIntyre, Barry J. Make, Fernando J. Martinez, Wassim W. Labaki, Jeffrey L. Curtis, Mei Lan K. Han

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. Trial registration: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.

Original language	English (US)
Article number	269
Journal	Respiratory research
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12931-019-1237-1
State	Published - Dec 2 2019

Keywords

Chronic obstructive pulmonary disease (COPD)
Diffusing capacity of the lung (DLCO)
Parametric response mapping (PRM)
Small airways disease (SAD)

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1186/s12931-019-1237-1

Cite this

Criner, R. N., Hatt, C. R., Galbán, C. J., Kazerooni, E. A., Lynch, D. A., McCormack, M. C., Casaburi, R., MacIntyre, N. R., Make, B. J., Martinez, F. J., Labaki, W. W., Curtis, J. L., & Han, M. L. K. (2019). Relationship between diffusion capacity and small airway abnormality in COPDGene. Respiratory research, 20(1), Article 269. https://doi.org/10.1186/s12931-019-1237-1

@article{887dc4a74f394d32ac0be6fe8d987730,

title = "Relationship between diffusion capacity and small airway abnormality in COPDGene",

abstract = "Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. Trial registration: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.",

keywords = "Chronic obstructive pulmonary disease (COPD), Diffusing capacity of the lung (DLCO), Parametric response mapping (PRM), Small airways disease (SAD)",

author = "Criner, {Rachel N.} and Hatt, {Charles R.} and Galb{\'a}n, {Craig J.} and Kazerooni, {Ella A.} and Lynch, {David A.} and McCormack, {Meredith C.} and Richard Casaburi and MacIntyre, {Neil R.} and Make, {Barry J.} and Martinez, {Fernando J.} and Labaki, {Wassim W.} and Curtis, {Jeffrey L.} and Han, {Mei Lan K.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s).",

year = "2019",

month = dec,

day = "2",

doi = "10.1186/s12931-019-1237-1",

language = "English (US)",

volume = "20",

journal = "Respiratory research",

issn = "1465-9921",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Relationship between diffusion capacity and small airway abnormality in COPDGene

AU - Criner, Rachel N.

AU - Hatt, Charles R.

AU - Galbán, Craig J.

AU - Kazerooni, Ella A.

AU - Lynch, David A.

AU - McCormack, Meredith C.

AU - Casaburi, Richard

AU - MacIntyre, Neil R.

AU - Make, Barry J.

AU - Martinez, Fernando J.

AU - Labaki, Wassim W.

AU - Curtis, Jeffrey L.

AU - Han, Mei Lan K.

PY - 2019/12/2

Y1 - 2019/12/2

N2 - Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. Trial registration: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.

AB - Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. Trial registration: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.

KW - Chronic obstructive pulmonary disease (COPD)

KW - Diffusing capacity of the lung (DLCO)

KW - Parametric response mapping (PRM)

KW - Small airways disease (SAD)

UR - http://www.scopus.com/inward/record.url?scp=85075914208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075914208&partnerID=8YFLogxK

U2 - 10.1186/s12931-019-1237-1

DO - 10.1186/s12931-019-1237-1

M3 - Article

C2 - 31791337

AN - SCOPUS:85075914208

SN - 1465-9921

VL - 20

JO - Respiratory research

JF - Respiratory research

IS - 1

M1 - 269

ER -

Relationship between diffusion capacity and small airway abnormality in COPDGene

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this