Relationship between calcium and hydrogen ions in heart muscle

A. R. Mattiazzi, H. E. Cingolani, E. Spacapan De Castuma

Research output: Contribution to journalArticle

Abstract

Developed tension (T), its maximal rate of rise [+dT/dt(max)], and maximal velocity of relaxation [-dT/dt(max)] were measured in cat papillary muscles, after changes in calcium concentration (Ca2+) at pH ~7.0, 7.4, and 7.6, produced by altering the PCO2 of the medium. Only the results obtained at the two extreme pH values were compared. Increasing [Ca2+] increased T, +dT/dt(max) and -dT/dt(max). At a given [Ca2+] high PCO2 significantly decreased T and +dT/dt(max). When T and +dT/dt(max) vs. [Ca2+] were plotted reciprocally, the ordinate intercepts of the lines, 1/E(max) significantly increased in acidosis (P <0.01). These data do not support the view of a competitive action between H+ and Ca2+ ions on the mechanical behavior of cardiac muscle. At a given [Ca2+], +dT/dt(max) was depressed significantly more than -dT/dt(max), i.e., at a [Ca2+] of 10 mM, the degree of depression of +dT/dt(max) and -dT/dt(max) was 41 ± 4% and 23 ± 5%, respectively (P <0.01). Furthermore, the slope of the regression line -dT/dt(max) vs. +dT/dt(max) was significantly higher in acidosis (P <0.01). Similar results were obtained in muscles depleted of catecholamines. These findings suggest that H+ ion might act upon the relaxation process.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume6
Issue number4
StatePublished - 1979
Externally publishedYes

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Acidosis
Protons
Myocardium
Ions
Calcium
Papillary Muscles
Catecholamines
Cats
Muscles

ASJC Scopus subject areas

  • Physiology

Cite this

Relationship between calcium and hydrogen ions in heart muscle. / Mattiazzi, A. R.; Cingolani, H. E.; Spacapan De Castuma, E.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 6, No. 4, 1979.

Research output: Contribution to journalArticle

Mattiazzi, A. R. ; Cingolani, H. E. ; Spacapan De Castuma, E. / Relationship between calcium and hydrogen ions in heart muscle. In: American Journal of Physiology - Heart and Circulatory Physiology. 1979 ; Vol. 6, No. 4.
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