### Abstract

Developed tension (T), its maximal rate of rise [+dT/dt(max)], and maximal velocity of relaxation [-dT/dt(max)] were measured in cat papillary muscles, after changes in calcium concentration (Ca^{2+}) at pH ~7.0, 7.4, and 7.6, produced by altering the PCO_{2} of the medium. Only the results obtained at the two extreme pH values were compared. Increasing [Ca^{2+}] increased T, +dT/dt(max) and -dT/dt(max). At a given [Ca^{2+}] high PCO_{2} significantly decreased T and +dT/dt(max). When T and +dT/dt(max) vs. [Ca^{2+}] were plotted reciprocally, the ordinate intercepts of the lines, 1/E(max) significantly increased in acidosis (P <0.01). These data do not support the view of a competitive action between H^{+} and Ca^{2+} ions on the mechanical behavior of cardiac muscle. At a given [Ca^{2+}], +dT/dt(max) was depressed significantly more than -dT/dt(max), i.e., at a [Ca^{2+}] of 10 mM, the degree of depression of +dT/dt(max) and -dT/dt(max) was 41 ± 4% and 23 ± 5%, respectively (P <0.01). Furthermore, the slope of the regression line -dT/dt(max) vs. +dT/dt(max) was significantly higher in acidosis (P <0.01). Similar results were obtained in muscles depleted of catecholamines. These findings suggest that H^{+} ion might act upon the relaxation process.

Original language | English (US) |
---|---|

Journal | American Journal of Physiology - Heart and Circulatory Physiology |

Volume | 6 |

Issue number | 4 |

State | Published - 1979 |

Externally published | Yes |

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### ASJC Scopus subject areas

- Physiology

### Cite this

*American Journal of Physiology - Heart and Circulatory Physiology*,

*6*(4).

**Relationship between calcium and hydrogen ions in heart muscle.** / Mattiazzi, A. R.; Cingolani, H. E.; Spacapan De Castuma, E.

Research output: Contribution to journal › Article

*American Journal of Physiology - Heart and Circulatory Physiology*, vol. 6, no. 4.

}

TY - JOUR

T1 - Relationship between calcium and hydrogen ions in heart muscle

AU - Mattiazzi, A. R.

AU - Cingolani, H. E.

AU - Spacapan De Castuma, E.

PY - 1979

Y1 - 1979

N2 - Developed tension (T), its maximal rate of rise [+dT/dt(max)], and maximal velocity of relaxation [-dT/dt(max)] were measured in cat papillary muscles, after changes in calcium concentration (Ca2+) at pH ~7.0, 7.4, and 7.6, produced by altering the PCO2 of the medium. Only the results obtained at the two extreme pH values were compared. Increasing [Ca2+] increased T, +dT/dt(max) and -dT/dt(max). At a given [Ca2+] high PCO2 significantly decreased T and +dT/dt(max). When T and +dT/dt(max) vs. [Ca2+] were plotted reciprocally, the ordinate intercepts of the lines, 1/E(max) significantly increased in acidosis (P <0.01). These data do not support the view of a competitive action between H+ and Ca2+ ions on the mechanical behavior of cardiac muscle. At a given [Ca2+], +dT/dt(max) was depressed significantly more than -dT/dt(max), i.e., at a [Ca2+] of 10 mM, the degree of depression of +dT/dt(max) and -dT/dt(max) was 41 ± 4% and 23 ± 5%, respectively (P <0.01). Furthermore, the slope of the regression line -dT/dt(max) vs. +dT/dt(max) was significantly higher in acidosis (P <0.01). Similar results were obtained in muscles depleted of catecholamines. These findings suggest that H+ ion might act upon the relaxation process.

AB - Developed tension (T), its maximal rate of rise [+dT/dt(max)], and maximal velocity of relaxation [-dT/dt(max)] were measured in cat papillary muscles, after changes in calcium concentration (Ca2+) at pH ~7.0, 7.4, and 7.6, produced by altering the PCO2 of the medium. Only the results obtained at the two extreme pH values were compared. Increasing [Ca2+] increased T, +dT/dt(max) and -dT/dt(max). At a given [Ca2+] high PCO2 significantly decreased T and +dT/dt(max). When T and +dT/dt(max) vs. [Ca2+] were plotted reciprocally, the ordinate intercepts of the lines, 1/E(max) significantly increased in acidosis (P <0.01). These data do not support the view of a competitive action between H+ and Ca2+ ions on the mechanical behavior of cardiac muscle. At a given [Ca2+], +dT/dt(max) was depressed significantly more than -dT/dt(max), i.e., at a [Ca2+] of 10 mM, the degree of depression of +dT/dt(max) and -dT/dt(max) was 41 ± 4% and 23 ± 5%, respectively (P <0.01). Furthermore, the slope of the regression line -dT/dt(max) vs. +dT/dt(max) was significantly higher in acidosis (P <0.01). Similar results were obtained in muscles depleted of catecholamines. These findings suggest that H+ ion might act upon the relaxation process.

UR - http://www.scopus.com/inward/record.url?scp=0018712294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018712294&partnerID=8YFLogxK

M3 - Article

VL - 6

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6135

IS - 4

ER -