Relationship Between C-Reactive Protein Levels and Regional Left Ventricular Function in Asymptomatic Individuals. The Multi-Ethnic Study of Atherosclerosis

Boaz D. Rosen, Mary Cushman, Khurram Nasir, David A. Bluemke, Thor Edvardsen, Verônica Fernandes, Shenghan Lai, Russell P. Tracy, Joao Lima

Research output: Contribution to journalArticle

Abstract

Objectives: This study sought to investigate the relationship between C-reactive protein (CRP) and regional left ventricular (LV) function in asymptomatic individuals without a history of cardiovascular disease. Background: C-reactive protein is associated with an increased risk for developing cardiovascular disease. However, the relationship between CRP and subclinical LV dysfunction has not been evaluated in asymptomatic individuals. Methods: Regional myocardial function was analyzed as peak systolic circumferential shortening strain (Ecc) using the harmonic-phase method by tagged magnetic resonance imaging in 1,164 individuals without symptomatic cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis) trial (age 66.4 ± 9.6 years old). Regions were defined by coronary territories: left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA). The relationship between log-CRP concentration and Ecc was studied by multivariable linear regression after adjustment for demographic characteristics, risk factors, and therapy (including hormone replacement therapy). Results: For each region, associations differed by gender with no association of CRP and regional LV function among women. In men, after adjustment, higher log-CRP was significantly associated with lower (absolute) Ecc in the LAD and RCA regions (regression coefficient 0.37 per unit higher log-CRP [95% confidence interval [CI] 0.08 to 0.65] and 0.31 [95% CI 0.02 to 0.59], respectively) and peak systolic Ecc overall (regression coefficient 0.32 [95% CI 0.05 to 0.58]). In the LCX region, the association was weaker (p = 0.06). Conclusions: Among individuals without evident heart failure or other cardiovascular disorders, higher CRP was associated with lower systolic myocardial function in all regions in men but not in women. These findings support the role of inflammation and atherosclerosis in incipient myocardial dysfunction. (Multi-Ethnic Study of Atherosclerosis; http://clinicaltrials.gov/ct/show/NCT00005487).

Original languageEnglish (US)
Pages (from-to)594-600
Number of pages7
JournalJournal of the American College of Cardiology
Volume49
Issue number5
DOIs
StatePublished - Feb 6 2007

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Left Ventricular Function
C-Reactive Protein
Atherosclerosis
Arteries
Cardiovascular Diseases
Confidence Intervals
Coronary Vessels
Hormone Replacement Therapy
Left Ventricular Dysfunction
Linear Models
Heart Failure
Magnetic Resonance Imaging
Demography
Inflammation

ASJC Scopus subject areas

  • Nursing(all)

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Relationship Between C-Reactive Protein Levels and Regional Left Ventricular Function in Asymptomatic Individuals. The Multi-Ethnic Study of Atherosclerosis. / Rosen, Boaz D.; Cushman, Mary; Nasir, Khurram; Bluemke, David A.; Edvardsen, Thor; Fernandes, Verônica; Lai, Shenghan; Tracy, Russell P.; Lima, Joao.

In: Journal of the American College of Cardiology, Vol. 49, No. 5, 06.02.2007, p. 594-600.

Research output: Contribution to journalArticle

Rosen, Boaz D. ; Cushman, Mary ; Nasir, Khurram ; Bluemke, David A. ; Edvardsen, Thor ; Fernandes, Verônica ; Lai, Shenghan ; Tracy, Russell P. ; Lima, Joao. / Relationship Between C-Reactive Protein Levels and Regional Left Ventricular Function in Asymptomatic Individuals. The Multi-Ethnic Study of Atherosclerosis. In: Journal of the American College of Cardiology. 2007 ; Vol. 49, No. 5. pp. 594-600.
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abstract = "Objectives: This study sought to investigate the relationship between C-reactive protein (CRP) and regional left ventricular (LV) function in asymptomatic individuals without a history of cardiovascular disease. Background: C-reactive protein is associated with an increased risk for developing cardiovascular disease. However, the relationship between CRP and subclinical LV dysfunction has not been evaluated in asymptomatic individuals. Methods: Regional myocardial function was analyzed as peak systolic circumferential shortening strain (Ecc) using the harmonic-phase method by tagged magnetic resonance imaging in 1,164 individuals without symptomatic cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis) trial (age 66.4 ± 9.6 years old). Regions were defined by coronary territories: left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA). The relationship between log-CRP concentration and Ecc was studied by multivariable linear regression after adjustment for demographic characteristics, risk factors, and therapy (including hormone replacement therapy). Results: For each region, associations differed by gender with no association of CRP and regional LV function among women. In men, after adjustment, higher log-CRP was significantly associated with lower (absolute) Ecc in the LAD and RCA regions (regression coefficient 0.37 per unit higher log-CRP [95{\%} confidence interval [CI] 0.08 to 0.65] and 0.31 [95{\%} CI 0.02 to 0.59], respectively) and peak systolic Ecc overall (regression coefficient 0.32 [95{\%} CI 0.05 to 0.58]). In the LCX region, the association was weaker (p = 0.06). Conclusions: Among individuals without evident heart failure or other cardiovascular disorders, higher CRP was associated with lower systolic myocardial function in all regions in men but not in women. These findings support the role of inflammation and atherosclerosis in incipient myocardial dysfunction. (Multi-Ethnic Study of Atherosclerosis; http://clinicaltrials.gov/ct/show/NCT00005487).",
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T1 - Relationship Between C-Reactive Protein Levels and Regional Left Ventricular Function in Asymptomatic Individuals. The Multi-Ethnic Study of Atherosclerosis

AU - Rosen, Boaz D.

AU - Cushman, Mary

AU - Nasir, Khurram

AU - Bluemke, David A.

AU - Edvardsen, Thor

AU - Fernandes, Verônica

AU - Lai, Shenghan

AU - Tracy, Russell P.

AU - Lima, Joao

PY - 2007/2/6

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N2 - Objectives: This study sought to investigate the relationship between C-reactive protein (CRP) and regional left ventricular (LV) function in asymptomatic individuals without a history of cardiovascular disease. Background: C-reactive protein is associated with an increased risk for developing cardiovascular disease. However, the relationship between CRP and subclinical LV dysfunction has not been evaluated in asymptomatic individuals. Methods: Regional myocardial function was analyzed as peak systolic circumferential shortening strain (Ecc) using the harmonic-phase method by tagged magnetic resonance imaging in 1,164 individuals without symptomatic cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis) trial (age 66.4 ± 9.6 years old). Regions were defined by coronary territories: left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA). The relationship between log-CRP concentration and Ecc was studied by multivariable linear regression after adjustment for demographic characteristics, risk factors, and therapy (including hormone replacement therapy). Results: For each region, associations differed by gender with no association of CRP and regional LV function among women. In men, after adjustment, higher log-CRP was significantly associated with lower (absolute) Ecc in the LAD and RCA regions (regression coefficient 0.37 per unit higher log-CRP [95% confidence interval [CI] 0.08 to 0.65] and 0.31 [95% CI 0.02 to 0.59], respectively) and peak systolic Ecc overall (regression coefficient 0.32 [95% CI 0.05 to 0.58]). In the LCX region, the association was weaker (p = 0.06). Conclusions: Among individuals without evident heart failure or other cardiovascular disorders, higher CRP was associated with lower systolic myocardial function in all regions in men but not in women. These findings support the role of inflammation and atherosclerosis in incipient myocardial dysfunction. (Multi-Ethnic Study of Atherosclerosis; http://clinicaltrials.gov/ct/show/NCT00005487).

AB - Objectives: This study sought to investigate the relationship between C-reactive protein (CRP) and regional left ventricular (LV) function in asymptomatic individuals without a history of cardiovascular disease. Background: C-reactive protein is associated with an increased risk for developing cardiovascular disease. However, the relationship between CRP and subclinical LV dysfunction has not been evaluated in asymptomatic individuals. Methods: Regional myocardial function was analyzed as peak systolic circumferential shortening strain (Ecc) using the harmonic-phase method by tagged magnetic resonance imaging in 1,164 individuals without symptomatic cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis) trial (age 66.4 ± 9.6 years old). Regions were defined by coronary territories: left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA). The relationship between log-CRP concentration and Ecc was studied by multivariable linear regression after adjustment for demographic characteristics, risk factors, and therapy (including hormone replacement therapy). Results: For each region, associations differed by gender with no association of CRP and regional LV function among women. In men, after adjustment, higher log-CRP was significantly associated with lower (absolute) Ecc in the LAD and RCA regions (regression coefficient 0.37 per unit higher log-CRP [95% confidence interval [CI] 0.08 to 0.65] and 0.31 [95% CI 0.02 to 0.59], respectively) and peak systolic Ecc overall (regression coefficient 0.32 [95% CI 0.05 to 0.58]). In the LCX region, the association was weaker (p = 0.06). Conclusions: Among individuals without evident heart failure or other cardiovascular disorders, higher CRP was associated with lower systolic myocardial function in all regions in men but not in women. These findings support the role of inflammation and atherosclerosis in incipient myocardial dysfunction. (Multi-Ethnic Study of Atherosclerosis; http://clinicaltrials.gov/ct/show/NCT00005487).

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