Relationship between blood pressure and airway obstruction during sleep in the dog

C. P. O'Donnell, E. D. King, A. R. Schwartz, J. L. Robotham, P. L. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between airway obstruction during sleep and changes in mean arterial pressure (MAP) was investigated in four chronically instrumented tracheostomized dogs during 12-h nocturnal experiments. The MAP response was determined 1) during experimental airway obstruction whenever sleep occurred, 2) over each 12-h experiment, and 3) during a 2-h recovery period at the end of each experiment. The effects of 24 h of sleep deprivation and changes in plasma levels of renin and atrial natriuretic peptide were assessed. In non-rapid-eye-movement sleep, a period of airway obstruction caused MAP to increase (P < 0.002) from 95 ± 3 (SE) mmHg to 112 ± 3 mmHg, and this difference was enhanced (P < 0.04) by sleep deprivation. There was an increase of 12 ± 2 mmHg in the overall MAP over time (P < 0.001) in non-rapid-eye-movement sleep that was sustained in the 2-h recovery period. Plasma levels of renin and atrial natriuretic peptide were constant and unrelated to changes in MAP. We conclude that in the sleeping dog airway obstruction causes an increase in MAP that can be accentuated by prior sleep deprivation and that repetitive airway obstruction will cause an increase in MAP over time that is sustained for ≥2 h when normal airway patency is restored.

Original languageEnglish (US)
Pages (from-to)1819-1828
Number of pages10
JournalJournal of applied physiology
Volume77
Issue number4
DOIs
StatePublished - Jan 1 1994

Keywords

  • arousal
  • atrial natriuretic peptide
  • cortisol
  • heart rate
  • hypoxia
  • mean arterial pressure
  • non-rapid-eye-movement sleep
  • plasma renin activity
  • rapid- eye-movement sleep
  • sleep deprivation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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