Relationship Between Arrhythmogenic Right Ventricular Dysplasia and Exercise

Abhishek C. Sawant; Hugh Calkins

doi:10.1016/j.ccep.2015.03.004

Relationship Between Arrhythmogenic Right Ventricular Dysplasia and Exercise

Abhishek C. Sawant, Hugh Calkins

School of Medicine

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is rare cardiomyopathy associated with life-threatening arrhythmias and increased risk of sudden cardiac death. In addition to mutations in desmosomal genes, environmental factors such as exercise have been implicated in the pathogenesis of the disease. Recent studies have shown that exercise may be associated with adverse outcomes in ARVD/C patients. Based on current evidence, ARVD/C patients are recommended to limit exercise irrespective of their mutation status. In addition, some studies have suggested the presence of an entirely acquired form of the disease caused by exercise that has been dubbed exercise-induced ARVD/C.

Original language	English (US)
Pages (from-to)	195-206
Number of pages	12
Journal	Cardiac Electrophysiology Clinics
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.ccep.2015.03.004
State	Published - Jun 1 2015

Keywords

Arrhythmogenic right ventricular dysplasia/cardiomyopathy
Exercise
Exercise-induced cardiomyopathy
Sudden cardiac death

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1016/j.ccep.2015.03.004

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title = "Relationship Between Arrhythmogenic Right Ventricular Dysplasia and Exercise",

abstract = "Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is rare cardiomyopathy associated with life-threatening arrhythmias and increased risk of sudden cardiac death. In addition to mutations in desmosomal genes, environmental factors such as exercise have been implicated in the pathogenesis of the disease. Recent studies have shown that exercise may be associated with adverse outcomes in ARVD/C patients. Based on current evidence, ARVD/C patients are recommended to limit exercise irrespective of their mutation status. In addition, some studies have suggested the presence of an entirely acquired form of the disease caused by exercise that has been dubbed exercise-induced ARVD/C.",

keywords = "Arrhythmogenic right ventricular dysplasia/cardiomyopathy, Exercise, Exercise-induced cardiomyopathy, Sudden cardiac death",

author = "Sawant, {Abhishek C.} and Hugh Calkins",

note = "Funding Information: Disclosures: Dr H. Calkins receives research support from the Dr. Francis P. Chiaramonte Private Foundation , St. Jude Medical , and Medtronic . Dr A.C. Sawant reports no conflict of interest. Funding Information: Sources of Funding: The Johns Hopkins ARVD/C Program is supported by the Leyla Erkan Family Fund for ARVD Research, the Dr Satish, Rupal, and Robin Shah ARVD Fund at Johns Hopkins , the Bogle Foundation , the Healing Hearts Foundation , the Campanella Family , the Patrick J. Harrison Family , the Peter French Memorial Foundation , and the Wilmerding Endowments . Publisher Copyright: {\textcopyright} 2015.",

year = "2015",

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doi = "10.1016/j.ccep.2015.03.004",

language = "English (US)",

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AU - Calkins, Hugh

N1 - Funding Information: Disclosures: Dr H. Calkins receives research support from the Dr. Francis P. Chiaramonte Private Foundation , St. Jude Medical , and Medtronic . Dr A.C. Sawant reports no conflict of interest. Funding Information: Sources of Funding: The Johns Hopkins ARVD/C Program is supported by the Leyla Erkan Family Fund for ARVD Research, the Dr Satish, Rupal, and Robin Shah ARVD Fund at Johns Hopkins , the Bogle Foundation , the Healing Hearts Foundation , the Campanella Family , the Patrick J. Harrison Family , the Peter French Memorial Foundation , and the Wilmerding Endowments . Publisher Copyright: © 2015.

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N2 - Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is rare cardiomyopathy associated with life-threatening arrhythmias and increased risk of sudden cardiac death. In addition to mutations in desmosomal genes, environmental factors such as exercise have been implicated in the pathogenesis of the disease. Recent studies have shown that exercise may be associated with adverse outcomes in ARVD/C patients. Based on current evidence, ARVD/C patients are recommended to limit exercise irrespective of their mutation status. In addition, some studies have suggested the presence of an entirely acquired form of the disease caused by exercise that has been dubbed exercise-induced ARVD/C.

AB - Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is rare cardiomyopathy associated with life-threatening arrhythmias and increased risk of sudden cardiac death. In addition to mutations in desmosomal genes, environmental factors such as exercise have been implicated in the pathogenesis of the disease. Recent studies have shown that exercise may be associated with adverse outcomes in ARVD/C patients. Based on current evidence, ARVD/C patients are recommended to limit exercise irrespective of their mutation status. In addition, some studies have suggested the presence of an entirely acquired form of the disease caused by exercise that has been dubbed exercise-induced ARVD/C.

KW - Arrhythmogenic right ventricular dysplasia/cardiomyopathy

KW - Exercise

KW - Exercise-induced cardiomyopathy

KW - Sudden cardiac death

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Relationship Between Arrhythmogenic Right Ventricular Dysplasia and Exercise

Abstract

Keywords

ASJC Scopus subject areas

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