Relationship Between Antihypertensive Medications and Cognitive Impairment: Part I. Review of Human Studies and Clinical Trials

Sevil Yasar, Mattan Schuchman, Jean Peters, Kaarin J. Anstey, Michelle C. Carlson, Ruth Peters

Research output: Contribution to journalReview article

Abstract

Purpose of review: There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews are comprehensive. Our extensive review includes 15 observational and randomized controlled trials (RCTs) published over the last 5 years, assessing the relationship between AHM and cognitive impairment. Recent findings: All classes of AHM showed similar result patterns in human studies with the majority of study results reporting point estimates below one and only a small number of studies (N = 15) reporting statistically significant results in favor of a specific class. Summary: Only a small number of studies reported statistically significant results in favor of a specific class of AHM. Methodological limitations of the studies prevent definitive conclusions. Further work is now needed to evaluate the class of AHM and cognitive outcomes in future RCTs, with a particular focus on the drugs with the promising results in both animals and human observational studies.

Original languageEnglish (US)
Article number67
JournalCurrent hypertension reports
Volume18
Issue number8
DOIs
StatePublished - Aug 1 2016

Keywords

  • Alzheimer’s disease
  • Antihypertensive medication
  • Cognitive decline
  • Dementia

ASJC Scopus subject areas

  • Internal Medicine

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