Relationship between anorectic and reinforcing properties of appetite suppressant drugs: Implications for assessment of abuse liability

Roland R Griffiths, J. V. Brady, J. D. Snell

Research output: Contribution to journalArticle

Abstract

A quantitative ratio measure was developed with permitted comparisons between the reinforcing and anorectic potency of eight phenylethylamine anorectics and cocaine in laboratory baboons. The ordering of these compounds based upon this ratio bears a reasonable correspondence to clinical drug evaluations. The measure may provide information for preclinical evaluation of relative abuse potential of anorectic drugs.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalBiological Psychiatry
Volume13
Issue number2
StatePublished - 1978

Fingerprint

Appetite Depressants
Phenethylamines
Drug Evaluation
Papio
Cocaine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Relationship between anorectic and reinforcing properties of appetite suppressant drugs : Implications for assessment of abuse liability. / Griffiths, Roland R; Brady, J. V.; Snell, J. D.

In: Biological Psychiatry, Vol. 13, No. 2, 1978, p. 283-290.

Research output: Contribution to journalArticle

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