Relationship Between Alternate-Day Corticosteroid Therapy and Behavioral Abnormalities

Steven S. Sharfstein, David S. Sack, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review


Three patients with inflammatory or immunologically mediated disease manifested striking behavioral abnormalities in association with long-term alternate-day prednisone regimens. Of particular note was the fact that differences in the abnormalities depended on the day that the patients received their drug: the symptoms that appeared on a treatment day were opposite those present on a day of no therapy. These symptoms were reminiscent of rapid mood cycling in some patients with manic-depressive affective disorder. The phenomenon was dose related and markedly diminished in two patients as the dosage of corticosteroid was decreased, despite the fact that the alternate-day regimen was continued.

Original languageEnglish (US)
Pages (from-to)2987-2989
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Issue number22
StatePublished - Dec 10 1982

ASJC Scopus subject areas

  • Medicine(all)


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