Abstract
Three patients with inflammatory or immunologically mediated disease manifested striking behavioral abnormalities in association with long-term alternate-day prednisone regimens. Of particular note was the fact that differences in the abnormalities depended on the day that the patients received their drug: the symptoms that appeared on a treatment day were opposite those present on a day of no therapy. These symptoms were reminiscent of rapid mood cycling in some patients with manic-depressive affective disorder. The phenomenon was dose related and markedly diminished in two patients as the dosage of corticosteroid was decreased, despite the fact that the alternate-day regimen was continued.
Original language | English (US) |
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Pages (from-to) | 2987-2989 |
Number of pages | 3 |
Journal | JAMA: The Journal of the American Medical Association |
Volume | 248 |
Issue number | 22 |
DOIs | |
State | Published - Dec 10 1982 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine