TY - JOUR
T1 - Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart
T2 - A non-invasive study using positron emission tomography
AU - Bengel, Frank M.
AU - Permanetter, B.
AU - Ungerer, M.
AU - Nekolla, S. G.
AU - Schwaiger, M.
PY - 2001
Y1 - 2001
N2 - Aims: To identify functional and metabolic correlates of impaired presynaptic sympathetic innervation in the cardiomyopathic human heart using non-invasive correlative imaging. Methods and Results: In 10 patients with idiopathic dilated cardiomyopathy, presynaptic catecholamine uptake sites were quantified by positron emission tomography with C-11 hydroxyephedrine. Oxidative metabolism was measured using C-11 acetate. Global and regional function was assessed by tomographic radionuclide angiography. Left ventricular ejection fraction in patients was 19% ± 10%. Myocardial hydroxyephedrine retention was abnormally low in 58% ± 38% of the left ventricles. Globally and regionally, hydroxyephedrine retention was significantly correlated with ventricular function (r=0.67, P=0.03 with left ventricular ejection fraction; r=0.31, P
AB - Aims: To identify functional and metabolic correlates of impaired presynaptic sympathetic innervation in the cardiomyopathic human heart using non-invasive correlative imaging. Methods and Results: In 10 patients with idiopathic dilated cardiomyopathy, presynaptic catecholamine uptake sites were quantified by positron emission tomography with C-11 hydroxyephedrine. Oxidative metabolism was measured using C-11 acetate. Global and regional function was assessed by tomographic radionuclide angiography. Left ventricular ejection fraction in patients was 19% ± 10%. Myocardial hydroxyephedrine retention was abnormally low in 58% ± 38% of the left ventricles. Globally and regionally, hydroxyephedrine retention was significantly correlated with ventricular function (r=0.67, P=0.03 with left ventricular ejection fraction; r=0.31, P
KW - Autonomic nervous system
KW - Heart failure
KW - Left ventricular function
KW - Oxidative metabolism
KW - Positron emission tomography
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U2 - 10.1053/euhj.2000.2556
DO - 10.1053/euhj.2000.2556
M3 - Article
C2 - 11492989
AN - SCOPUS:0034863241
VL - 22
SP - 1594
EP - 1600
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 17
ER -