Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart: A non-invasive study using positron emission tomography

Frank M. Bengel, B. Permanetter, M. Ungerer, S. G. Nekolla, M. Schwaiger

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To identify functional and metabolic correlates of impaired presynaptic sympathetic innervation in the cardiomyopathic human heart using non-invasive correlative imaging. Methods and Results: In 10 patients with idiopathic dilated cardiomyopathy, presynaptic catecholamine uptake sites were quantified by positron emission tomography with C-11 hydroxyephedrine. Oxidative metabolism was measured using C-11 acetate. Global and regional function was assessed by tomographic radionuclide angiography. Left ventricular ejection fraction in patients was 19% ± 10%. Myocardial hydroxyephedrine retention was abnormally low in 58% ± 38% of the left ventricles. Globally and regionally, hydroxyephedrine retention was significantly correlated with ventricular function (r=0.67, P=0.03 with left ventricular ejection fraction; r=0.31, P

Original languageEnglish (US)
Pages (from-to)1594-1600
Number of pages7
JournalEuropean Heart Journal
Volume22
Issue number17
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Autonomic nervous system
  • Heart failure
  • Left ventricular function
  • Oxidative metabolism
  • Positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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