Abstract
Aims: To identify functional and metabolic correlates of impaired presynaptic sympathetic innervation in the cardiomyopathic human heart using non-invasive correlative imaging. Methods and Results: In 10 patients with idiopathic dilated cardiomyopathy, presynaptic catecholamine uptake sites were quantified by positron emission tomography with C-11 hydroxyephedrine. Oxidative metabolism was measured using C-11 acetate. Global and regional function was assessed by tomographic radionuclide angiography. Left ventricular ejection fraction in patients was 19% ± 10%. Myocardial hydroxyephedrine retention was abnormally low in 58% ± 38% of the left ventricles. Globally and regionally, hydroxyephedrine retention was significantly correlated with ventricular function (r=0.67, P=0.03 with left ventricular ejection fraction; r=0.31, P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1594-1600 |
| Number of pages | 7 |
| Journal | European Heart Journal |
| Volume | 22 |
| Issue number | 17 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Autonomic nervous system
- Heart failure
- Left ventricular function
- Oxidative metabolism
- Positron emission tomography
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart : A non-invasive study using positron emission tomography. / Bengel, Frank M.; Permanetter, B.; Ungerer, M.; Nekolla, S. G.; Schwaiger, M.
In: European Heart Journal, Vol. 22, No. 17, 2001, p. 1594-1600.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart
T2 - A non-invasive study using positron emission tomography
AU - Bengel, Frank M.
AU - Permanetter, B.
AU - Ungerer, M.
AU - Nekolla, S. G.
AU - Schwaiger, M.
PY - 2001
Y1 - 2001
N2 - Aims: To identify functional and metabolic correlates of impaired presynaptic sympathetic innervation in the cardiomyopathic human heart using non-invasive correlative imaging. Methods and Results: In 10 patients with idiopathic dilated cardiomyopathy, presynaptic catecholamine uptake sites were quantified by positron emission tomography with C-11 hydroxyephedrine. Oxidative metabolism was measured using C-11 acetate. Global and regional function was assessed by tomographic radionuclide angiography. Left ventricular ejection fraction in patients was 19% ± 10%. Myocardial hydroxyephedrine retention was abnormally low in 58% ± 38% of the left ventricles. Globally and regionally, hydroxyephedrine retention was significantly correlated with ventricular function (r=0.67, P=0.03 with left ventricular ejection fraction; r=0.31, P
AB - Aims: To identify functional and metabolic correlates of impaired presynaptic sympathetic innervation in the cardiomyopathic human heart using non-invasive correlative imaging. Methods and Results: In 10 patients with idiopathic dilated cardiomyopathy, presynaptic catecholamine uptake sites were quantified by positron emission tomography with C-11 hydroxyephedrine. Oxidative metabolism was measured using C-11 acetate. Global and regional function was assessed by tomographic radionuclide angiography. Left ventricular ejection fraction in patients was 19% ± 10%. Myocardial hydroxyephedrine retention was abnormally low in 58% ± 38% of the left ventricles. Globally and regionally, hydroxyephedrine retention was significantly correlated with ventricular function (r=0.67, P=0.03 with left ventricular ejection fraction; r=0.31, P
KW - Autonomic nervous system
KW - Heart failure
KW - Left ventricular function
KW - Oxidative metabolism
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=0034863241&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034863241&partnerID=8YFLogxK
U2 - 10.1053/euhj.2000.2556
DO - 10.1053/euhj.2000.2556
M3 - Article
C2 - 11492989
AN - SCOPUS:0034863241
VL - 22
SP - 1594
EP - 1600
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 17
ER -