Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

Austin G. Hester, Robert C. Murphy, Charis J. Uhlson, Priscilla Ivester, Tammy C. Lee, Susan Sergeant, Leslie R. Miller, Timothy D. Howard, Rasika A. Mathias, Floyd H. Chilton

Research output: Contribution to journalArticle

Abstract

Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.

Original languageEnglish (US)
Pages (from-to)22482-22489
Number of pages8
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Hester, A. G., Murphy, R. C., Uhlson, C. J., Ivester, P., Lee, T. C., Sergeant, S., Miller, L. R., Howard, T. D., Mathias, R. A., & Chilton, F. H. (2014). Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans. Journal of Biological Chemistry, 289(32), 22482-22489. https://doi.org/10.1074/jbc.M114.579557