Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

Austin G. Hester, Robert C. Murphy, Charis J. Uhlson, Priscilla Ivester, Tammy C. Lee, Susan Sergeant, Leslie R. Miller, Timothy D. Howard, Rasika Mathias, Floyd H. Chilton

Research output: Contribution to journalArticle

Abstract

Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.

Original languageEnglish (US)
Pages (from-to)22482-22489
Number of pages8
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

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Fatty Acid Desaturases
Eicosanoids
Single Nucleotide Polymorphism
Arachidonate 5-Lipoxygenase
Leukotriene B4
Biosynthesis
Blood
Inflammation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Hester, A. G., Murphy, R. C., Uhlson, C. J., Ivester, P., Lee, T. C., Sergeant, S., ... Chilton, F. H. (2014). Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans. Journal of Biological Chemistry, 289(32), 22482-22489. https://doi.org/10.1074/jbc.M114.579557

Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans. / Hester, Austin G.; Murphy, Robert C.; Uhlson, Charis J.; Ivester, Priscilla; Lee, Tammy C.; Sergeant, Susan; Miller, Leslie R.; Howard, Timothy D.; Mathias, Rasika; Chilton, Floyd H.

In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22482-22489.

Research output: Contribution to journalArticle

Hester, AG, Murphy, RC, Uhlson, CJ, Ivester, P, Lee, TC, Sergeant, S, Miller, LR, Howard, TD, Mathias, R & Chilton, FH 2014, 'Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans', Journal of Biological Chemistry, vol. 289, no. 32, pp. 22482-22489. https://doi.org/10.1074/jbc.M114.579557
Hester, Austin G. ; Murphy, Robert C. ; Uhlson, Charis J. ; Ivester, Priscilla ; Lee, Tammy C. ; Sergeant, Susan ; Miller, Leslie R. ; Howard, Timothy D. ; Mathias, Rasika ; Chilton, Floyd H. / Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 32. pp. 22482-22489.
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