Relation of systolic, diastolic, and pulse pressures and aortic distensibility with atrial fibrillation (from the Multi-Ethnic Study of Atherosclerosis)

Nicholas S. Roetker, Lin Y. Chen, Susan R. Heckbert, Saman Nazarian, Elsayed Z. Soliman, David A. Bluemke, Joao Lima, Alvaro Alonso

Research output: Contribution to journalArticle

Abstract

Previous research suggests that elevated pulse pressure (PP) is a risk factor for atrial fibrillation (AF) independently of mean arterial pressure (MAP). PP may serve as an indirect measure of aortic stiffness (reduced distensibility), but whether directly measured aortic distensibility is related to risk for AF has not yet been studied. This analysis included 6,630 participants aged 45 to 84 years from the Multi-Ethnic Study of Atherosclerosis. At baseline, blood pressure and other relevant covariates were measured using standardized protocols. Magnetic resonance imaging-based aortic distensibility was measured in 3,441 participants. Incident AF was identified from hospitalization discharge codes and Medicare claims. Multivariate Cox models were used to estimate the association of blood pressure components and aortic distensibility with AF risk. During a mean follow-up of 7.8 years, 307 AF events (137 among those with aortic distensibility measurements) were identified. In multivariate-adjusted models simultaneously including MAP and PP, each 1-SD increase in PP was associated with a 29% increased risk of AF (95% confidence interval 5% to 59%, p = 0.02), with MAP not being associated with increased AF risk. Overall, aortic distensibility was not consistently associated with AF risk: after removing outliers, each 1-SD increase in aortic distensibility was associated with a 9% increased risk of AF (95% confidence interval -22% to 51%, p = 0.63). In conclusion, in this large community-based cohort, we found that PP, but not MAP or aortic distensibility, was a significant risk factor for AF, emphasizing the importance of PP when assessing the risk for developing AF. Our results cast doubt on the clinical utility of aortic distensibility as a predictor for the development of AF.

Original languageEnglish (US)
Pages (from-to)587-592
Number of pages6
JournalThe American Journal of Cardiology
Volume114
Issue number4
DOIs
StatePublished - Aug 15 2014

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Atrial Fibrillation
Atherosclerosis
Blood Pressure
Arterial Pressure
Confidence Intervals
Vascular Stiffness
Medicare
Proportional Hazards Models
Hospitalization
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Relation of systolic, diastolic, and pulse pressures and aortic distensibility with atrial fibrillation (from the Multi-Ethnic Study of Atherosclerosis). / Roetker, Nicholas S.; Chen, Lin Y.; Heckbert, Susan R.; Nazarian, Saman; Soliman, Elsayed Z.; Bluemke, David A.; Lima, Joao; Alonso, Alvaro.

In: The American Journal of Cardiology, Vol. 114, No. 4, 15.08.2014, p. 587-592.

Research output: Contribution to journalArticle

Roetker, Nicholas S. ; Chen, Lin Y. ; Heckbert, Susan R. ; Nazarian, Saman ; Soliman, Elsayed Z. ; Bluemke, David A. ; Lima, Joao ; Alonso, Alvaro. / Relation of systolic, diastolic, and pulse pressures and aortic distensibility with atrial fibrillation (from the Multi-Ethnic Study of Atherosclerosis). In: The American Journal of Cardiology. 2014 ; Vol. 114, No. 4. pp. 587-592.
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AU - Nazarian, Saman

AU - Soliman, Elsayed Z.

AU - Bluemke, David A.

AU - Lima, Joao

AU - Alonso, Alvaro

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